Imperial College London
Alternate

DrGeraldLarrouy-Maumus

Faculty of Natural Sciences, Department of Life Sciences

Reader in Molecular Microbiology
 
 
 
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Contact

 

+44 (0)20 7594 7463g.larrouy-maumus

 
 
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Location

 

3.42Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Krokowski:2018:10.1016/j.chom.2018.11.005,
author = {Krokowski, S and Lobato-Marquez, D and Chastanet, A and Pereira, PM and Angelis, D and Galea, D and Larrouy-Maumus, G and Henriques, R and Spiliotis, ET and Carballido-Lopez, R and Mostowy, S},
doi = {10.1016/j.chom.2018.11.005},
journal = {Cell Host and Microbe},
pages = {866--874},
title = {Septins recognize and entrap dividing bacterial cells for delivery to lysosomes},
url = {http://dx.doi.org/10.1016/j.chom.2018.11.005},
volume = {24},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The cytoskeleton occupies a central role in cellular immunity by promoting bacterial sensing and antibacterial functions. Septins are cytoskeletal proteins implicated in various cellular processes, including cell division. Septins also assemble into cage-like structures that entrap cytosolic Shigella, yet how septins recognize bacteria is poorly understood. Here, we discover that septins are recruited to regions of micron-scale membrane curvature upon invasion and division by a variety of bacterial species. Cardiolipin, a curvature-specific phospholipid, promotes septin recruitment to highly curved membranes of Shigella, and bacterial mutants lacking cardiolipin exhibit less septin cage entrapment. Chemically inhibiting cell separation to prolong membrane curvature or reducing Shigella cell growth respectively increases and decreases septin cage formation. Once formed, septin cages inhibit Shigella cell division upon recruitment of autophagic and lysosomal machinery. Thus, recognition of dividing bacterial cells by the septin cytoskeleton is a powerful mechanism to restrict the proliferation of intracellular bacterial pathogens.
AU  - Krokowski,S
AU  - Lobato-Marquez,D
AU  - Chastanet,A
AU  - Pereira,PM
AU  - Angelis,D
AU  - Galea,D
AU  - Larrouy-Maumus,G
AU  - Henriques,R
AU  - Spiliotis,ET
AU  - Carballido-Lopez,R
AU  - Mostowy,S
DO  - 10.1016/j.chom.2018.11.005
EP  - 874
PY  - 2018///
SN  - 1931-3128
SP  - 866
TI  - Septins recognize and entrap dividing bacterial cells for delivery to lysosomes
T2  - Cell Host and Microbe
UR  - http://dx.doi.org/10.1016/j.chom.2018.11.005
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000453027400013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.sciencedirect.com/science/article/pii/S1931312818305626?via%3Dihub
UR  - http://hdl.handle.net/10044/1/66816
VL  - 24
ER  -
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