Summary
The goal of Professor Taylor's group is to improve the the diagnosis and treatment of human retroviruses and sexually transmitted infections. The diagnostic focus is developing accessible tools to detect early disease and minimal residual disease in patients with Adult T-cell Leukaemia/Lymphoma (ATL). The group has MRC/Leuka support to study the step wise development of malignancy in patients infected with human T-cell lymphotropic Virus type 1 (HTLV-1) and identify patients at high risk of ATL with a view to earlier treatment. The clinical arm of the group is the National Centre for Human Retrovirology (https://www.imperial.nhs.uk/our-services/sexual-health.../human-t-lymphotropic-virus) at Imperial College Healthcare NHS Trust, which is the major reference centre for patients in the UK infected with HTLV. Clinical research includes treatment of ATLL, pathogenesis studies into HTLV-associated myelopathy (HAM) and novel imaging of the central nervous system in patients with HAM in partnership with Imanova. The Molecular Diagnostic Unit of the Section of Virology translates the research into patient care providing novel diagnostics to the NHS. https://www.imperial.ac.uk/medicine/molecular-diagnostic-unit/diagnostic-services/htlv-load-testing-and-genotyping/
The group's HIV research has centered on the safe management of HIV infection in pregnancy. The group is a founder partner in PANNA conducting pharmacokinetic studies of antiretroviral therapies in pregnancy http://www.pannastudy.com/network as well as the London HIV Pregnancy Research Group. Our primary goal at present is a better understanding of the relationship between HIV infection, treatment and preterm delivery. This includes an exploration of the cervico-vaginal microbiota and its role in pregnancy outcome in HIV infected women, working closely with the March of Dimes team at the March of Dimes Prematurity Research Center at Imperial College. https://www.marchofdimes.org/research/prematurity-research-center-imperial-college.aspx
thus transforming scientifc research into steps to improve HIV pregnancy outcome, fetal and neonatal development, in a bench to bedside manner.
The development and application of quantitative assays for T. pallidum is the third project in the group's portfolio - a natural extension from the HTLV diagnostics.
Selected Publications
Journal Articles
Rosadas de Oliveira C, Harvala H, Davison K, et al., 2023, HTLV-1 screening of blood donations: we are systematically missing opportunities, British Journal of Haematology, Vol:202, ISSN:0007-1048, Pages:1220-1223
Rosadas C, Senna K, da Costa M, et al., 2023, Economic analysis of antenatal screening for human T-cell lymphotropic virus type 1 in Brazil: an open access cost-utility model, The Lancet Global Health, Vol:11, ISSN:2214-109X, Pages:e781-e790
Harding D, Rosadas C, Tsoti S, et al., 2022, Refining the risk of HTLV-1-associated myelopathy in people living with HTLV-1: Identification of a HAM-like phenotype in a proportion of asymptomatic carriers, Journal of Neurovirology, Vol:28, ISSN:1355-0284, Pages:473-482
Rosadas C, Taylor GP, 2022, Current interventions to prevent HTLV-1 mother-to-child transmission and their effectiveness: a systematic review and meta-analysis., Microorganisms, Vol:10, ISSN:2076-2607, Pages:1-15
Barr R, Drysdale S, Boullier M, et al., 2022, A review of the prevention of mother-to-child transmission of human T-cell lymphotropic virus type 1 (HTLV-1) with a proposed management algorithm, Frontiers in Medicine, Vol:9, ISSN:2296-858X, Pages:1-7
Rosadas de Oliveira C, Zetterberg H, Heslegrave A, et al., 2021, Neurofilament light in CSF and plasma is a marker of neuronal damage in HTLV-1-associated myelopathy and correlates with neuroinflammation, Neurology, Neuroimmunology and Neuroinflammation, Vol:8, ISSN:2332-7812, Pages:1-7
Eke AC, Olagunju A, Momper J, et al., 2021, Optimizing pharmacology studies in pregnant and lactating women using lessons from HIV: a consensus statement., Clinical Pharmacology & Therapeutics, Vol:110, ISSN:0009-9236, Pages:36-48
Wolf S, Haddow J, Greiller C, et al., 2021, Quantification of T cell clonality in Human T cell leukaemia virus type-1 carriers can detect the development of Adult T cell Leukaemia early, Blood Cancer Journal, Vol:11, ISSN:2044-5385, Pages:1-11
Rosadas C, Assone T, Yamashita M, et al., 2020, Health state utility values in people living with HTLV-1 and in patients with HAM/TSP: The impact of a neglected disease on the quality of life, PLOS Neglected Tropical Diseases, Vol:14, ISSN:1935-2727
Cloke T, Munder M, Taylor G, et al., 2012, Characterization of a novel population of low-density granulocytes associated with disease severity in HIV-1 infection, PLOS One, Vol:7, ISSN:1932-6203