Job Title: Professor and Head of Section of Cell Biology and Functional Genomics
Research: Signal transduction in the pancreatic β-cell in health and disease - my chief focus is in using functional genomics at the cellular and whole organism level to dissect the role of genes associated with Type 2 diabetes.
Brief Biosketch: After studying for a PhD in Bristol with Dick Denton FRS on mitochondrial Ca2+ signalling, I subsequently worked on the pancreatic β-cell as an MRC travelling Fellow with Claes Wollheim in Geneva. There, working collaboratively with Tullio Pozzan and Rosario Rizzuto in Padua, I established new approaches to exploring the control of insulin release at the single cell level through the use of recombinant target probes and other techniques. I then returned to Bristol, becoming a full Professor of Biochemistry in 2002, and moved to Imperial College in 2006.
My current research is supported by Wellcome Trust Senior Investigator and Royal Society Wolfson Merit Awards, by UK Research Council and Diabetes UK grants, as well as by the European Commission Innovative Medicines Initiative in Diabetes (IMIDIA).
Prizes and Awards: I was awarded the Minkowski Prize of the European Association for the Study of Diabetes in 2004, the Juvenile Diabetes Research Foundation's Mary Jane Krugel Award (2005), a Royal Society Wolfson Research Merit Award (2011), a Wellcome Trust Senior Investigator Award (2012) and the Dorothy Hodgkin Lecturehip of Diabetes UK (2014).
Research Support. Supported by Programme and other grants from the Wellcome Trust, MRC, DUK, JDRF, BBSRC, NIH, BHF and EU.
et al., Targeting GLP-1 receptor trafficking to improve agonist efficacy, Nature Communications, ISSN:2041-1723
et al., 2016, Changes in the expression of the type 2 diabetes-associated gene VPS13C in the β-cell are associated with glucose intolerance in humans and mice., Am J Physiol Endocrinol Metab, Vol:311, Pages:E488-E507
et al., Co-operation between Epidermal Growth Factor Receptor and Glucagon-like Peptide 1 Receptor in Pancreatic Beta Cell Survival during Oxidative stress, Emj Diabetes, ISSN:2054-6181
pullen T, Huising MO, Rutter GA, Analysis of purified pancreatic islet beta and alpha cell transcriptomes reveals 11β-hydroxysteroid dehydrogenase (Hsd11b1) as a novel disallowed gene, Frontiers in Genetics, ISSN:1664-8021
et al., PAS-domain containing protein kinase (PASK) is required for the regulation of food intake and glucose homeostasis, Annual Professional Conference of the American Diabetes Association, American Diabetes Association, ISSN:0012-1797