Imperial College London

ProfessorGuyRutter

Faculty of MedicineDepartment of Medicine

Chair in Cell Biology and Head of Cell Biology
 
 
 
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Contact

 

+44 (0)20 7594 3340g.rutter Website

 
 
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Assistant

 

Ms Shazi Singh +44 (0)20 7594 3391

 
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Location

 

327ICTEM buildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

448 results found

Buenaventura T, Kanda N, Jones B, Correa IR, Bloom SR, Rutter GA, Tomas Aet al., 2017, Characterisation of glucagon-like peptide-1 (GLP-1) receptor trafficking and its significance for pancreatic beta cell function, DIABETIC MEDICINE, Vol: 34, Pages: 53-53, ISSN: 0742-3071

JOURNAL ARTICLE

Carrat G, Haythorne E, Chabosseau P, Hodson DJ, Catala AT, Rutter GAet al., 2017, Role of StarD10 in beta cell physiology, 53rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Publisher: SPRINGER, Pages: S190-S191, ISSN: 0012-186X

CONFERENCE PAPER

Carrat GR, Hu M, Nguyen-Tu M-S, Chabosseau P, Gaulton KJ, van de Bunt M, Siddiq A, Falchi M, Thurner M, Canouil M, Pattou F, Leclerc I, Pullen TJ, Cane MC, Prabhala P, Greenwald W, Schulte A, Marchetti P, Ibberson M, MacDonald PE, Fox JEM, Gloyn AL, Froguel P, Solimena M, McCarthy MI, Rutter GAet al., 2017, Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice, AMERICAN JOURNAL OF HUMAN GENETICS, Vol: 100, Pages: 238-256, ISSN: 0002-9297

JOURNAL ARTICLE

Cruciani-Guglielmacci C, Bellini L, Denom J, Oshima M, Fernandez N, Normandie-Levi P, Berney XP, Kassis N, Rouch C, Dairou J, Gorman T, Smith DM, Marley A, Liechti R, Kuznetsov D, Wigger L, Burdet F, Lefevre A-L, Wehrle I, Uphues I, Hildebrandt T, Rust W, Bernard C, Ktorza A, Rutter GA, Scharfmann R, Xenarios I, Le Stunff H, Thorens B, Magnan C, Ibberson Met al., 2017, Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion, MOLECULAR METABOLISM, Vol: 6, Pages: 340-351, ISSN: 2212-8778

JOURNAL ARTICLE

Fine NHF, Doig CL, Elhassan Y, Marchetti P, Bugliani M, Piemonti L, Rutter GA, Jacobson DA, Lavery GG, Hodson DJet al., 2017, Glucocorticoids re-programme the beta cell signalling cassette to preserve functional identity and insulin secretion, 53rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Publisher: SPRINGER, Pages: S83-S83, ISSN: 0012-186X

CONFERENCE PAPER

Fine NHF, Doig CL, Elhassan Y, Rutter GA, Lavery GG, Hodson DJet al., 2017, A steroid-regulated feedback loop preserves insulin secretion in the face of perturbed beta cell function, DIABETIC MEDICINE, Vol: 34, Pages: 41-41, ISSN: 0742-3071

JOURNAL ARTICLE

Gao T, Chabosseau P, Rutter GA, Leclerc Iet al., 2017, Sorcin stimulates ATF6 transcriptional activity, DIABETIC MEDICINE, Vol: 34, Pages: 43-43, ISSN: 0742-3071

JOURNAL ARTICLE

Gerber PA, Rutter GA, 2017, The Role of Oxidative Stress and Hypoxia in Pancreatic Beta-Cell Dysfunction in Diabetes Mellitus, ANTIOXIDANTS & REDOX SIGNALING, Vol: 26, Pages: 501-+, ISSN: 1523-0864

JOURNAL ARTICLE

Gharavy SNM, Li X, Martinez-Sanchez A, Rutter GAet al., 2017, Putative roles of the Type 2 diabetes-associated genes C2CD4A and C2CD4B in the control of insulin secretion, DIABETIC MEDICINE, Vol: 34, Pages: 79-79, ISSN: 0742-3071

JOURNAL ARTICLE

Haythorne EA, Martinez-Sanchez A, Rizzuto R, Rutter GAet al., 2017, The mitochondrial Ca2+ uniporter (MCUa) is required for glucose-stimulated mitochondrial Ca2+ uptake and insulin secretion in mouse pancreatic beta cells, 53rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Publisher: SPRINGER, Pages: S197-S197, ISSN: 0012-186X

CONFERENCE PAPER

Hodson DJ, Nasteska D, Fine NHF, Rutter GA, Zhou Qet al., 2017, Forced maturity in pancreatic beta cells impairs islet function, 53rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Publisher: SPRINGER, Pages: S183-S183, ISSN: 0012-186X

CONFERENCE PAPER

Martinez-Sanchez A, Marchetti P, Shapiro AMJ, Rutter GAet al., 2017, AMP-activated protein kinase (AMPK) regulates miRNA expression in beta cells, DIABETIC MEDICINE, Vol: 34, Pages: 42-43, ISSN: 0742-3071

JOURNAL ARTICLE

Martinez-Sanchez A, Rutter GA, Latreille M, 2017, MiRNAs in beta-Cell Development, Identity, and Disease, FRONTIERS IN GENETICS, Vol: 7, ISSN: 1664-8021

JOURNAL ARTICLE

Martinez-Sanchez A, Shapiro J, Marchetti P, Sakamoto K, Smith DM, Leclerc I, Rutter GAet al., 2017, AMP-Activated Protein Kinase (AMPK) Regulates beta-Cell MicroRNA Expression, 77th Scientific Sessions of the American-Diabetes-Association, Publisher: AMER DIABETES ASSOC, Pages: A29-A29, ISSN: 0012-1797

CONFERENCE PAPER

Mehta ZB, Johnston NR, Nguyen-Tu M-S, Broichhagen J, Schultz P, Larner DP, Leclerc I, Trauner D, Rutter GA, Hodson DJet al., 2017, Remote control of glucose homeostasis in vivo using photopharmacology, SCIENTIFIC REPORTS, Vol: 7, ISSN: 2045-2322

JOURNAL ARTICLE

Mitchell RK, Nguyen-Tu M-S, Chabosseau P, Callingham RM, Pullen TJ, Cheung R, Leclerc I, Hodson DJ, Rutter GAet al., 2017, The transcription factor Pax6 is required for pancreatic beta cell identity, glucose-regulated ATP synthesis, and Ca2+ dynamics in adult mice, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 292, Pages: 8892-8906, ISSN: 0021-9258

JOURNAL ARTICLE

Nasteska D, Fine NHF, Rutter GA, Zhou Q, Hodson DJet al., 2017, beta cell diversity is required for normal islet function, Publisher: WILEY, Pages: 12-14, ISSN: 1748-1708

CONFERENCE PAPER

Nguyen-Tu M-S, Xavier GDS, Leclerc I, Rutter GAet al., 2017, The Type 2 Diabetes Gene TCF7L2 Modulates the Impact of LKB1 Deletion on Beta-Cell Function, 77th Scientific Sessions of the American-Diabetes-Association, Publisher: AMER DIABETES ASSOC, Pages: A577-A577, ISSN: 0012-1797

CONFERENCE PAPER

Nguyen-Tu MS, Leclerc I, daSilva-Xavier G, Rutter GAet al., 2017, The Type 2 diabetes genome-wide association study (GWAS) gene TCF7L2 modulates the response of the murine beta cell to deletion of the tumour suppressor Lkb1, DIABETIC MEDICINE, Vol: 34, Pages: 28-28, ISSN: 0742-3071

JOURNAL ARTICLE

Perez Y, Shorer Z, Liani-Leibson K, Chabosseau P, Kadir R, Volodarsky M, Halperin D, Barber-Zucker S, Shalev H, Schreiber R, Gradstein L, Gurevich E, Zarivach R, Rutter GA, Landau D, Birk OSet al., 2017, SLC30A9 mutation affecting intracellular zinc homeostasis causes a novel cerebro-renal syndrome, BRAIN, Vol: 140, Pages: 928-939, ISSN: 0006-8950

JOURNAL ARTICLE

Ralston JC, Nguyen-Tu M-S, Lyons CL, Murphy AM, Cooke AA, Falvey A, Finucane OM, Rutter GA, Roche HMet al., 2017, A dietary switch from saturated to monounsaturated fat is protective against metabolic dysregulation, hyperinsulinaemia and beta cell dysfunction, 53rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Publisher: SPRINGER, Pages: S267-S268, ISSN: 0012-186X

CONFERENCE PAPER

Rutter GA, 2017, Controlling the identity of the adult pancreatic beta cell, NATURE REVIEWS ENDOCRINOLOGY, Vol: 13, Pages: 129-+, ISSN: 1759-5029

JOURNAL ARTICLE

Rutter GA, 2017, GABA signaling: A route to new pancreatic beta cells, CELL RESEARCH, Vol: 27, Pages: 309-310, ISSN: 1001-0602

JOURNAL ARTICLE

Rutter GA, Hodson DJ, Chabosseau P, Haythorne E, Pullen TJ, Leclerc Iet al., 2017, Local and regional control of calcium dynamics in the pancreatic islet, DIABETES OBESITY & METABOLISM, Vol: 19, Pages: 30-41, ISSN: 1462-8902

JOURNAL ARTICLE

Solimena M, Schulte AM, Marselli L, Ehehalt F, Richter D, Kleeberg M, Mziaut H, Knoch K-P, Parnis J, Bugliani M, Siddiq A, Jörns A, Burdet F, Liechti R, Suleiman M, Margerie D, Syed F, Distler M, Grützmann R, Petretto E, Moreno-Moral A, Wegbrod C, Sönmez A, Pfriem K, Friedrich A, Meinel J, Wollheim CB, Baretton GB, Scharfmann R, Nogoceke E, Bonifacio E, Sturm D, Meyer-Puttlitz B, Boggi U, Saeger H-D, Filipponi F, Lesche M, Meda P, Dahl A, Wigger L, Xenarios I, Falchi M, Thorens B, Weitz J, Bokvist K, Lenzen S, Rutter GA, Froguel P, von Bülow M, Ibberson M, Marchetti Pet al., 2017, Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes., Diabetologia

AIMS/HYPOTHESIS: Pancreatic islet beta cell failure causes type 2 diabetes in humans. To identify transcriptomic changes in type 2 diabetic islets, the Innovative Medicines Initiative for Diabetes: Improving beta-cell function and identification of diagnostic biomarkers for treatment monitoring in Diabetes (IMIDIA) consortium ( www.imidia.org ) established a comprehensive, unique multicentre biobank of human islets and pancreas tissues from organ donors and metabolically phenotyped pancreatectomised patients (PPP). METHODS: Affymetrix microarrays were used to assess the islet transcriptome of islets isolated either by enzymatic digestion from 103 organ donors (OD), including 84 non-diabetic and 19 type 2 diabetic individuals, or by laser capture microdissection (LCM) from surgical specimens of 103 PPP, including 32 non-diabetic, 36 with type 2 diabetes, 15 with impaired glucose tolerance (IGT) and 20 with recent-onset diabetes (<1 year), conceivably secondary to the pancreatic disorder leading to surgery (type 3c diabetes). Bioinformatics tools were used to (1) compare the islet transcriptome of type 2 diabetic vs non-diabetic OD and PPP as well as vs IGT and type 3c diabetes within the PPP group; and (2) identify transcription factors driving gene co-expression modules correlated with insulin secretion ex vivo and glucose tolerance in vivo. Selected genes of interest were validated for their expression and function in beta cells. RESULTS: Comparative transcriptomic analysis identified 19 genes differentially expressed (false discovery rate ≤0.05, fold change ≥1.5) in type 2 diabetic vs non-diabetic islets from OD and PPP. Nine out of these 19 dysregulated genes were not previously reported to be dysregulated in type 2 diabetic islets. Signature genes included TMEM37, which inhibited Ca2+-influx and insulin secretion in beta cells, and ARG2 and PPP1R1A, which promoted insulin secretion. Systems biology approaches identified HNF1A, PDX1 and REST as drivers o

JOURNAL ARTICLE

Tuncay E, Bitirim VC, Durak A, Carrat GRJ, Taylor KM, Rutter GA, Turan Bet al., 2017, Hyperglycemia-Induced Changes in ZIP7 and ZnT7 Expression Cause Zn2+ Release From the Sarco(endo)plasmic Reticulum and Mediate ER Stress in the Heart, DIABETES, Vol: 66, Pages: 1346-1358, ISSN: 0012-1797

JOURNAL ARTICLE

Akalestou E, Christakis I, Solomou AM, Minnion JS, Rutter GA, Bloom SRet al., 2016, Proglucagon-Derived Peptides Do Not Significantly Affect Acute Exocrine Pancreas in Rats, PANCREAS, Vol: 45, Pages: 967-973, ISSN: 0885-3177

JOURNAL ARTICLE

Broichhagen J, Johnston NR, von Ohlen Y, Meyer-Berg H, Jones BJ, Bloom SR, Rutter GA, Trauner D, Hodson DJet al., 2016, Allosteric Optical Control of a Class B G-Protein-Coupled Receptor, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol: 55, Pages: 5865-5868, ISSN: 1433-7851

JOURNAL ARTICLE

Broichhagen J, von Ohlen Y, Johnston NR, Meyer-Berg H, Jones BJ, Bloom SR, Rutter GA, Trauner D, Hodson DJet al., 2016, Optical control of the glucagon-like peptide-1 receptor allosteric site, DIABETIC MEDICINE, Vol: 33, Pages: 60-60, ISSN: 0742-3071

JOURNAL ARTICLE

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