Imperial College London

ProfessorGuyRutter

Faculty of MedicineDepartment of Medicine

Chair in Cell Biology and Head of Cell Biology
 
 
 
//

Contact

 

+44 (0)20 7594 3340g.rutter Website

 
 
//

Assistant

 

Ms Shazi Singh +44 (0)20 7594 3391

 
//

Location

 

327ICTEM buildingHammersmith Campus

//

Summary

 

Publications

Publication Type
Year
to

442 results found

Da Silva Xavier G, Mondragon A, Mourougavelou V, Cruciani-Guglielmacci C, Denom J, Herrera PL, Magnan C, Rutter GAet al., Pancreatic alpha cell-selective deletion of Tcf7l2 impairs glucagon secretion and counter-regulatory responses in mice, Diabetologia, ISSN: 0012-186X

Background and Aims.Transcription Factor 7-Like 2 (TCF7L2) is a high mobility group (HMG) box-containing transcription factor and downstream effector of the Wntsignalling pathway. Single nucleotide polymorphisms in the TCF7L2gene have previously been associated with an increased risk of type 2 diabetes in genome-wide association studies. Loss of Tcf7l2function is associated with defective islet beta cell function and survival. Here, we explore the roles of TCF7L2 in the control of the counter-regulatory response to hypoglycaemia by generating mice deleted selectively for the Tcf7l2gene in pancreatic alpha cells.Methods.Alpha cell-selective deletion of Tcf7l2was achieved by crossing animals with floxed Tcf7l2alleles to mice bearing a Crerecombinase transgene driven by the preproglucagon promoter (PPGCre; Tcf7l2AKO). Glucose homeostasis and hormone secretion in vivoand in vitro, and islet cell mass, were measured using standard techniques.Results. Whilst glucose tolerance was unaffected in Tcf7l2AKO mice, glucose infusion rates were increased, and glucagon secretion tended to be lower, during hypoglycemic clamps. Tcf7l2AKO displayed lowered fasted plasma glucose concentration. Glucagon release at low glucose was impaired (p<0.05) in islets isolated from Tcf7l2AKO mice. Alpha cell mass was lowered in Tcf7l2AKO mice.Conclusions.The present findings demonstrate an alpha cell autonomous role for Tcf7l2 in the control of pancreatic glucagon secretion and the maintenance of alpha cell mass and function.

JOURNAL ARTICLE

Kanda N, Buenaventura T, Correa Jr IR, Bosco D, Rutter GA, Tomas Catala ADDet al., Co-operation between Epidermal Growth Factor Receptor and Glucagon-like Peptide 1 Receptor in Pancreatic Beta Cell Survival during Oxidative stress, EMJ Diabetes, ISSN: 2054-6181

JOURNAL ARTICLE

Mondragon A, Hodson D, Semplici F, Mikami T, Ishii R, Rutter G, da Silva Xavier Get al., PAS-domain containing protein kinase (PASK) is required for the regulation of food intake and glucose homeostasis, Annual Professional Conference of the American Diabetes Association, Publisher: American Diabetes Association, ISSN: 0012-1797

CONFERENCE PAPER

Buenaventura T, Kanda N, Jones B, Correa IR, Bloom SR, Rutter GA, Tomas Aet al., 2017, Characterisation of glucagon-like peptide-1 (GLP-1) receptor trafficking and its significance for pancreatic beta cell function, DIABETIC MEDICINE, Vol: 34, Pages: 53-53, ISSN: 0742-3071

JOURNAL ARTICLE

Carrat GR, Hu M, Nguyen-Tu M-S, Chabosseau P, Gaulton KJ, van de Bunt M, Siddiq A, Falchi M, Thurner M, Canouil M, Pattou F, Leclerc I, Pullen TJ, Cane MC, Prabhala P, Greenwald W, Schulte A, Marchetti P, Ibberson M, MacDonald PE, Fox JEM, Gloyn AL, Froguel P, Solimena M, McCarthy MI, Rutter GAet al., 2017, Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice, AMERICAN JOURNAL OF HUMAN GENETICS, Vol: 100, Pages: 238-256, ISSN: 0002-9297

JOURNAL ARTICLE

Cruciani-Guglielmacci C, Bellini L, Denom J, Oshima M, Fernandez N, Normandie-Levi P, Berney XP, Kassis N, Rouch C, Dairou J, Gorman T, Smith DM, Marley A, Liechti R, Kuznetsov D, Wigger L, Burdet F, Lefevre A-L, Wehrle I, Uphues I, Hildebrandt T, Rust W, Bernard C, Ktorza A, Rutter GA, Scharfmann R, Xenarios I, Le Stunff H, Thorens B, Magnan C, Ibberson Met al., 2017, Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion, MOLECULAR METABOLISM, Vol: 6, Pages: 340-351, ISSN: 2212-8778

JOURNAL ARTICLE

Fine NHF, Doig CL, Elhassan Y, Rutter GA, Lavery GG, Hodson DJet al., 2017, A steroid-regulated feedback loop preserves insulin secretion in the face of perturbed beta cell function, DIABETIC MEDICINE, Vol: 34, Pages: 41-41, ISSN: 0742-3071

JOURNAL ARTICLE

Gao T, Chabosseau P, Rutter GA, Leclerc Iet al., 2017, Sorcin stimulates ATF6 transcriptional activity, DIABETIC MEDICINE, Vol: 34, Pages: 43-43, ISSN: 0742-3071

JOURNAL ARTICLE

Gerber PA, Rutter GA, 2017, The Role of Oxidative Stress and Hypoxia in Pancreatic Beta-Cell Dysfunction in Diabetes Mellitus, ANTIOXIDANTS & REDOX SIGNALING, Vol: 26, Pages: 501-+, ISSN: 1523-0864

JOURNAL ARTICLE

Gharavy SNM, Li X, Martinez-Sanchez A, Rutter GAet al., 2017, Putative roles of the Type 2 diabetes-associated genes C2CD4A and C2CD4B in the control of insulin secretion, DIABETIC MEDICINE, Vol: 34, Pages: 79-79, ISSN: 0742-3071

JOURNAL ARTICLE

Martinez-Sanchez A, Marchetti P, Shapiro AMJ, Rutter GAet al., 2017, AMP-activated protein kinase (AMPK) regulates miRNA expression in beta cells, DIABETIC MEDICINE, Vol: 34, Pages: 42-43, ISSN: 0742-3071

JOURNAL ARTICLE

Martinez-Sanchez A, Rutter GA, Latreille M, 2017, MiRNAs in beta-Cell Development, Identity, and Disease, FRONTIERS IN GENETICS, Vol: 7, ISSN: 1664-8021

JOURNAL ARTICLE

Martinez-Sanchez A, Shapiro J, Marchetti P, Sakamoto K, Smith DM, Leclerc I, Rutter GAet al., 2017, AMP-Activated Protein Kinase (AMPK) Regulates beta-Cell MicroRNA Expression, 77th Scientific Sessions of the American-Diabetes-Association, Publisher: AMER DIABETES ASSOC, Pages: A29-A29, ISSN: 0012-1797

CONFERENCE PAPER

Mehta ZB, Johnston NR, Nguyen-Tu M-S, Broichhagen J, Schultz P, Larner DP, Leclerc I, Trauner D, Rutter GA, Hodson DJet al., 2017, Remote control of glucose homeostasis in vivo using photopharmacology, SCIENTIFIC REPORTS, Vol: 7, ISSN: 2045-2322

JOURNAL ARTICLE

Mitchell RK, Nguyen-Tu M-S, Chabosseau P, Callingham RM, Pullen TJ, Cheung R, Leclerc I, Hodson DJ, Rutter GAet al., 2017, The transcription factor Pax6 is required for pancreatic beta cell identity, glucose-regulated ATP synthesis, and Ca2+ dynamics in adult mice, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 292, Pages: 8892-8906, ISSN: 0021-9258

JOURNAL ARTICLE

Nasteska D, Fine NHF, Rutter GA, Zhou Q, Hodson DJet al., 2017, beta cell diversity is required for normal islet function, Publisher: WILEY, Pages: 12-14, ISSN: 1748-1708

CONFERENCE PAPER

Nguyen-Tu M-S, Xavier GDS, Leclerc I, Rutter GAet al., 2017, The Type 2 Diabetes Gene TCF7L2 Modulates the Impact of LKB1 Deletion on Beta-Cell Function, 77th Scientific Sessions of the American-Diabetes-Association, Publisher: AMER DIABETES ASSOC, Pages: A577-A577, ISSN: 0012-1797

CONFERENCE PAPER

Nguyen-Tu MS, Leclerc I, daSilva-Xavier G, Rutter GAet al., 2017, The Type 2 diabetes genome-wide association study (GWAS) gene TCF7L2 modulates the response of the murine beta cell to deletion of the tumour suppressor Lkb1, DIABETIC MEDICINE, Vol: 34, Pages: 28-28, ISSN: 0742-3071

JOURNAL ARTICLE

Perez Y, Shorer Z, Liani-Leibson K, Chabosseau P, Kadir R, Volodarsky M, Halperin D, Barber-Zucker S, Shalev H, Schreiber R, Gradstein L, Gurevich E, Zarivach R, Rutter GA, Landau D, Birk OSet al., 2017, SLC30A9 mutation affecting intracellular zinc homeostasis causes a novel cerebro-renal syndrome, BRAIN, Vol: 140, Pages: 928-939, ISSN: 0006-8950

JOURNAL ARTICLE

Rutter GA, 2017, Diabetes: Controlling the identity of the adult pancreatic β cell., Nat Rev Endocrinol, Vol: 13, Pages: 129-130

JOURNAL ARTICLE

Rutter GA, 2017, GABA signaling: A route to new pancreatic beta cells, CELL RESEARCH, Vol: 27, Pages: 309-310, ISSN: 1001-0602

JOURNAL ARTICLE

Rutter GA, Hodson DJ, Chabosseau P, Haythorne E, Pullen TJ, Leclerc Iet al., 2017, Local and regional control of calcium dynamics in the pancreatic islet, DIABETES OBESITY & METABOLISM, Vol: 19, Pages: 30-41, ISSN: 1462-8902

JOURNAL ARTICLE

Tuncay E, Bitirim VC, Durak A, Carrat GRJ, Taylor KM, Rutter GA, Turan Bet al., 2017, Hyperglycemia-Induced Changes in ZIP7 and ZnT7 Expression Cause Zn2+ Release From the Sarco(endo)plasmic Reticulum and Mediate ER Stress in the Heart, DIABETES, Vol: 66, Pages: 1346-1358, ISSN: 0012-1797

JOURNAL ARTICLE

Akalestou E, Christakis I, Solomou AM, Minnion JS, Rutter GA, Bloom SRet al., 2016, Proglucagon-Derived Peptides Do Not Significantly Affect Acute Exocrine Pancreas in Rats, PANCREAS, Vol: 45, Pages: 967-973, ISSN: 0885-3177

JOURNAL ARTICLE

Broichhagen J, Johnston NR, von Ohlen Y, Meyer-Berg H, Jones BJ, Bloom SR, Rutter GA, Trauner D, Hodson DJet al., 2016, Allosteric Optical Control of a Class B G-Protein-Coupled Receptor, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol: 55, Pages: 5865-5868, ISSN: 1433-7851

JOURNAL ARTICLE

Broichhagen J, von Ohlen Y, Johnston NR, Meyer-Berg H, Jones BJ, Bloom SR, Rutter GA, Trauner D, Hodson DJet al., 2016, Optical control of the glucagon-like peptide-1 receptor allosteric site, DIABETIC MEDICINE, Vol: 33, Pages: 60-60, ISSN: 0742-3071

JOURNAL ARTICLE

Cane MC, Parrington J, Rorsman P, Galione A, Rutter GAet al., 2016, The two pore channel TPC2 is dispensable in pancreatic beta-cells for normal Ca2+ dynamics and insulin secretion, CELL CALCIUM, Vol: 59, Pages: 32-40, ISSN: 0143-4160

JOURNAL ARTICLE

Carrat GR, Nguyen-Tu M-S, Hu M, Chabosseau P, Siddiq A, Falchi M, Froguel P, Schulte A, Ibberson M, Thorens B, Marchetti P, Solimena M, Cane M, Rutter GAet al., 2016, Deletion of the type 2 diabetes-associated gene product StarD10 in mice impairs insulin secretion and action, 52nd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Publisher: SPRINGER, Pages: S88-S88, ISSN: 0012-186X

CONFERENCE PAPER

Chabosseau P, Rutter GA, 2016, Zinc and diabetes, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, Vol: 611, Pages: 79-85, ISSN: 0003-9861

JOURNAL ARTICLE

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

Request URL: http://wlsprd.imperial.ac.uk:80/respub/WEB-INF/jsp/search-html.jsp Request URI: /respub/WEB-INF/jsp/search-html.jsp Query String: respub-action=search.html&id=00462876&limit=30&person=true