Imperial College London

ProfessorGuyRutter

Faculty of MedicineDepartment of Medicine

Chair in Cell Biology and Head of Cell Biology
 
 
 
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Contact

 

+44 (0)20 7594 3340g.rutter Website

 
 
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Assistant

 

Ms Shazi Singh +44 (0)20 7594 3391

 
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Location

 

327ICTEM buildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

492 results found

Buenaventura T, Kanda N, Douzenis PC, Jones B, Bloom SR, Chabosseau P, Correa IR, Bosco D, Piemonti L, Marchetti P, Johnson PR, Shapiro AMJ, Rutter GA, Tomas Aet al., 2018, A Targeted RNAi Screen Identifies Endocytic Trafficking Factors That Control GLP-1 Receptor Signaling in Pancreatic beta-Cells, DIABETES, Vol: 67, Pages: 385-399, ISSN: 0012-1797

JOURNAL ARTICLE

Callingham RM, Pullen TJ, Rutter GA, 2018, The role of a long non-coding RNA at the Pax6 locus in controlling beta cell identity and function, Publisher: WILEY, Pages: 50-50, ISSN: 0742-3071

CONFERENCE PAPER

Carrat GR, Haythorne E, Chabosseau P, Hodson D, Pullen TJ, Catala AT, Haataja L, Leclerc I, Arvan P, Rutter GAet al., 2018, The Type 2 diabetes genome-wide association study (GWAS) gene STARD10 controls beta cell granule morphogenesis and proinsulin release, Publisher: WILEY, Pages: 46-46, ISSN: 0742-3071

CONFERENCE PAPER

Chabosseau P, Cheung R, Rutter GA, 2018, CRISPR/Cas9-mediated engineering of insulin-secreting cells to study Type 2 diabetes risk variants of the gene SLC30A8/ZnT8 the Zn2+transporter, Publisher: WILEY, Pages: 45-45, ISSN: 0742-3071

CONFERENCE PAPER

Chabosseau P, Woodier J, Cheung R, Rutter GAet al., 2018, Sensors for measuring subcellular zinc pools, METALLOMICS, Vol: 10, Pages: 229-239, ISSN: 1756-5901

JOURNAL ARTICLE

Cheung R, Rolando D, Chabosseau P, Sakamoto K, Smith DM, Rutter GA, Martinez-Sanchez Aet al., 2018, miR-125b is a new regulator of pancreatic beta cell function, Publisher: WILEY, Pages: 47-47, ISSN: 0742-3071

CONFERENCE PAPER

Fine NHF, Doig CL, Elhassan YS, Vierra NC, Marchetti P, Bugliani M, Nano R, Piemonti L, Rutter GA, Jacobson DA, Lavery GG, Hodson DJet al., 2018, Glucocorticoids Reprogram beta-Cell Signaling to Preserve Insulin Secretion, DIABETES, Vol: 67, Pages: 278-290, ISSN: 0012-1797

JOURNAL ARTICLE

Gharavy NM, Li X, Leclerc I, Martinez-Sanchez A, Rutter GAet al., 2018, Roles for the Type 2 diabetes-associated genes C2CD4A and C2CD4B in the control of insulin secretion, Publisher: WILEY, Pages: 40-41, ISSN: 0742-3071

CONFERENCE PAPER

Hamilton A, Zhang Q, Salehi A, Willems M, Knudsen JG, Ringgaard AK, Chapman CE, Gonzalez-Alvarez A, Surdo NC, Zaccolo M, Basco D, Johnson PRV, Ramracheya R, Rutter GA, Galione A, Rorsman P, Tarasov AIet al., 2018, Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent Ca2+ Mobilization From Acidic Stores in Pancreatic alpha-Cells, DIABETES, Vol: 67, Pages: 1128-1139, ISSN: 0012-1797

JOURNAL ARTICLE

Izzi-Engbeaya C, Comninos AN, Clarke SA, Jomard A, Yang L, Jones S, Abbara A, Narayanaswamy S, Eng PC, Papadopoulou D, Prague JK, Bech P, Godsland IF, Bassett P, Sands C, Camuzeaux S, Gomez-Romero M, Pearce JTM, Lewis MR, Holmes E, Nicholson JK, Tan T, Ratnasabapathy R, Hu M, Carrat G, Piemonti L, Bugliani M, Marchetti P, Johnson PR, Hughes SJ, James Shapiro AM, Rutter GA, Dhillo WSet al., 2018, The effects of kisspeptin on β-cell function, serum metabolites and appetite in humans., Diabetes Obes Metab

AIMS: To investigate the effect of kisspeptin on glucose-stimulated insulin secretion and appetite in humans. MATERIALS AND METHODS: In 15 healthy men (age: 25.2 ± 1.1 years; BMI: 22.3 ± 0.5 kg m-2 ), we compared the effects of 1 nmol kg-1 h-1 kisspeptin versus vehicle administration on glucose-stimulated insulin secretion, metabolites, gut hormones, appetite and food intake. In addition, we assessed the effect of kisspeptin on glucose-stimulated insulin secretion in vitro in human pancreatic islets and a human β-cell line (EndoC-βH1 cells). RESULTS: Kisspeptin administration to healthy men enhanced insulin secretion following an intravenous glucose load, and modulated serum metabolites. In keeping with this, kisspeptin increased glucose-stimulated insulin secretion from human islets and a human pancreatic cell line in vitro. In addition, kisspeptin administration did not alter gut hormones, appetite or food intake in healthy men. CONCLUSIONS: Collectively, these data demonstrate for the first time a beneficial role for kisspeptin in insulin secretion in humans in vivo. This has important implications for our understanding of the links between reproduction and metabolism in humans, as well as for the ongoing translational development of kisspeptin-based therapies for reproductive and potentially metabolic conditions.

JOURNAL ARTICLE

Janjuha S, Singh SP, Tsakmaki A, Gharavy SNM, Murawala P, Konantz J, Birke S, Hodson DJ, Rutter GA, Bewick GA, Ninov Net al., 2018, Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish, ELIFE, Vol: 7, ISSN: 2050-084X

JOURNAL ARTICLE

Jenkins A, Lengyel I, Rutter GA, Lowe N, Shai I, Tirosh A, Petro T, Khamaisi M, Andrews S, Zmora N, Gross A, Maret W, Lewis EC, Moran Aet al., 2018, Obesity, diabetes and zinc: A workshop promoting knowledge and collaboration between the UK and Israel, november 28-30, 2016-Israel, JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, Vol: 49, Pages: 79-85, ISSN: 0946-672X

JOURNAL ARTICLE

Jones B, Bloom SR, Buenaventura T, Tomas A, Rutter GAet al., 2018, Control of insulin secretion by GLP-1, PEPTIDES, Vol: 100, Pages: 75-84, ISSN: 0196-9781

JOURNAL ARTICLE

Jones B, Buenaventura T, Kanda N, Chabosseau P, Owen BM, Scott R, Goldin R, Angkathunyakul N, Correa IR, Bosco D, Johnson PR, Piemonti L, Marchetti P, Shapiro AMJ, Cochran BJ, Hanyaloglu AC, Inoue A, Tan T, Rutter GA, Tomas A, Bloom SRet al., 2018, Targeting GLP-1 receptor trafficking to improve agonist efficacy, NATURE COMMUNICATIONS, Vol: 9, ISSN: 2041-1723

JOURNAL ARTICLE

Khan R, Kanda N, Bloom SR, Rutter GA, Lindsley CW, Nance KD, Niswender KD, Jones B, Tomas Aet al., 2018, An investigation into the role of compound 5d in incretin-dependent pancreatic beta cell function, Publisher: WILEY, Pages: 54-54, ISSN: 0742-3071

CONFERENCE PAPER

Kimura T, Obata A, Shimoda M, Shimizu I, Xavier GDS, Okauchi S, Hirukawa H, Kohara K, Mune T, Moriuchi S, Hiraoka A, Tamura K, Chikazawa G, Ishida A, Yoshitaka H, Rutter GA, Kaku K, Kaneto Het al., 2018, Down-regulation of vascular GLP-1 receptor expression in human subjects with obesity, SCIENTIFIC REPORTS, Vol: 8, ISSN: 2045-2322

JOURNAL ARTICLE

Kleiner S, Gomez D, Megra B, Na E, Bhavsar R, Cavino K, Xin Y, Rojas J, Dominguez-Gutierrez G, Zambrowicz B, Carrat G, Chabosseau P, Hu M, Murphy AJ, Yancopoulos GD, Rutter GA, Gromada Jet al., 2018, Mice harboring the human SLC30A8 R138X loss-of-function mutation have increased insulin secretory capacity, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 115, Pages: E7642-E7649, ISSN: 0027-8424

JOURNAL ARTICLE

Laughlin WE, Buenaventura T, Oqua AI, Kanda N, Walker A, Klymchenko AS, Bloom SR, Rutter GA, Hanyaloglu A, Jones B, Tomas Aet al., 2018, Control of glucagon-like peptide-1 receptor (GLP-1R) palmitoylation, lipid raft partitioning, clustering and signalling by biased agonism, Publisher: WILEY, Pages: 54-55, ISSN: 0742-3071

CONFERENCE PAPER

Ma Y, Ratnasabapathy R, Izzi-Engbeaya C, Nguyen-Tu M-S, Richardson E, Hussain S, De Backer I, Holton C, Norton M, Carrat G, Schwappach B, Rutter GA, Dhillo WS, Gardiner Jet al., 2018, Hypothalamic arcuate nucleus glucokinase regulates insulin secretion and glucose homeostasis, DIABETES OBESITY & METABOLISM, Vol: 20, Pages: 2246-2254, ISSN: 1462-8902

JOURNAL ARTICLE

Martinez-Sanchez A, Nguyen-Tu M-S, Cebola I, Yavari A, Marchetti P, Piemonti L, de Koning E, Shapiro AMJ, Johnson P, Sakamoto K, Smith DM, Leclerc I, Ashrafian H, Ferrer J, Rutter GAet al., 2018, MiR-184 expression is regulated by AMPK in pancreatic islets, FASEB JOURNAL, Vol: 32, Pages: 2587-2600, ISSN: 0892-6638

JOURNAL ARTICLE

Martinez-Sanchez A, Nguyen-Tu M-S, Leclerc I, Rutter GAet al., 2018, Manipulation and Measurement of AMPK Activity in Pancreatic Islets., Methods Mol Biol, Vol: 1732, Pages: 413-431

The role of the energy sensor AMPK-activated protein kinase (AMPK) in the insulin-secreting β-cell remains unclear and a subject of intense research. With this chapter, we aim to provide a detailed description of the methods that our group routinely applies to the study of AMPK function in mouse and human pancreatic islets. Thus, we provide detailed protocols to isolate and/or culture mouse and human islets, to modulate and measure AMPK activity in isolated islets, and to evaluate its impact on islet function.

JOURNAL ARTICLE

Martinez-Sanchez A, Nguyen-Tu MS, Cebola I, Yavari A, Marchetti P, Piemonti L, Leclerc I, Sakamoto K, Smith DM, Rutter GAet al., 2018, Adenosine Monophosphate (AMP)-activated protein kinase (AMPK) regulates the expression of miR-184 and other miRNAs important for beta cell function, Publisher: WILEY, Pages: 48-48, ISSN: 0742-3071

CONFERENCE PAPER

Martinez-Sanchez A, Pizza G, Marchetti P, Piemonti L, Johnson P, Sakamoto K, Smith DK, Leclerc I, Rutter GAet al., 2018, Glucose regulates miR-125b expression via AMP-activated protein kinase (AMPK), Publisher: WILEY, Pages: 49-49, ISSN: 0742-3071

CONFERENCE PAPER

Millership SJ, Xavier GDS, Choudhury AI, Bertazzo S, Chabosseau P, Pedroni SMA, Irvine EE, Montoya A, Faull P, Taylor WR, Kerr-Conte J, Pattou F, Ferrer J, Christian M, John RM, Latreille M, Liu M, Rutter GA, Scott J, Withers DJet al., 2018, Neuronatin regulates pancreatic beta cell insulin content and secretion, JOURNAL OF CLINICAL INVESTIGATION, Vol: 128, Pages: 3369-3381, ISSN: 0021-9738

JOURNAL ARTICLE

Nguyen-Tu M-S, da Silva Xavier G, Leclerc I, Rutter GAet al., 2018, Transcription factor-7-like 2 (TCF7L2) gene acts downstream of the Lkb1/Stk11 kinase to control mTOR signaling, β cell growth, and insulin secretion., J Biol Chem, Vol: 293, Pages: 14178-14189

Variants in the transcription factor-7-like 2 (TCF7L2/TCF4) gene, involved in Wnt signaling, are associated with type 2 diabetes. Loss of Tcf7l2 selectively from the β cell in mice has previously been shown to cause glucose intolerance and to lower β cell mass. Deletion of the tumor suppressor liver kinase B1 (LKB1/STK11) leads to β cell hyperplasia and enhanced glucose-stimulated insulin secretion, providing a convenient genetic model for increased β cell growth and function. The aim of this study was to explore the possibility that Tcf7l2 may be required for the effects of Lkb1 deletion on insulin secretion in the mouse β cell. Mice bearing floxed Lkb1 and/or Tcf7l2 alleles were bred with knockin mice bearing Cre recombinase inserted at the Ins1 locus (Ins1Cre), allowing highly β cell-selective deletion of either or both genes. Oral glucose tolerance was unchanged by the further deletion of a single Tcf7l2 allele in these cells. By contrast, mice lacking both Tcf7l2 alleles on this background showed improved oral glucose tolerance and insulin secretion in vivo and in vitro compared with mice lacking a single Tcf7l2 allele. Biallelic Tcf7l2 deletion also enhanced β cell proliferation, increased β cell mass, and caused changes in polarity as revealed by the "rosette-like" arrangement of β cells. Tcf7l2 deletion also increased signaling by mammalian target of rapamycin (mTOR), augmenting phospho-ribosomal S6 levels. We identified a novel signaling mechanism through which a modifier gene, Tcf7l2, lies on a pathway through which LKB1 acts in the β cell to restrict insulin secretion.

JOURNAL ARTICLE

Nguyen-Tu MS, Rutter GA, Xavier GD, 2018, Adipose tissue-selective deletion of the Type 2 diabetes Genome-wide association studies (GWAS) gene Tcf7l2 in mice impairs insulin sensitivity and secretion, Publisher: WILEY, Pages: 83-84, ISSN: 0742-3071

CONFERENCE PAPER

Pullen TJ, Groen N, van Oudenaarden A, Hodson DJ, Carlotti F, Rutter GAet al., 2018, Identification of potential hub beta cells using single-cell RNA-Seq, Publisher: WILEY, Pages: 51-51, ISSN: 0742-3071

CONFERENCE PAPER

Rutter GA, Haythorne EA, Georgiadou E, Xavier GDS, Pullen TJ, Rizzuto R, Martinez-Sanchez A, McGinty JA, French PMet al., 2018, Pancreatic beta cell-selective deletion of the mitochondrial calcium uniporter (MCU) impairs glucose-stimulated insulin secretion in vitro but not in vivo, Publisher: WILEY, Pages: 42-42, ISSN: 0742-3071

CONFERENCE PAPER

Rutter GA, Hodson DJ, 2018, Beta cell connectivity in pancreatic islets: a type 2 diabetes target? (vol 72, pg 453, 2015), CELLULAR AND MOLECULAR LIFE SCIENCES, Vol: 75, Pages: 1303-1305, ISSN: 1420-682X

JOURNAL ARTICLE

Scott F, Parks S, Gao T, Awuapura NJ, Ayathamattam J, Valdivia H, Rutter GA, Leclerc Iet al., 2018, The calcium sensor sorcin maintains activating transcription factor 6 (ATF6) transcriptional activity while lowering ER stress, Publisher: WILEY, Pages: 44-44, ISSN: 0742-3071

CONFERENCE PAPER

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