Publications
674 results found
Nicolson TJ, Bellomo EA, Wijesekara N, et al., 2009, Insulin Storage and Glucose Homeostasis in Mice Null for the Granule Zinc Transporter ZnT8 and Studies of the Type 2 Diabetes-Associated Variants, DIABETES, Vol: 58, Pages: 2070-2083, ISSN: 0012-1797
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- Citations: 297
Vinkenborg JL, Nicolson TJ, Bellomo EA, et al., 2009, Genetically encoded FRET sensors to monitor intracellular Zn2+ homeostasis, Nature Methods, Vol: 6, Pages: 737-740, ISSN: 1548-7105
Xavier GDS, Loder MK, McDonald A, et al., 2009, TCF7L2 Regulates Late Events in Insulin Secretion From Pancreatic Islet β-Cells, DIABETES, Vol: 58, Pages: 894-905, ISSN: 0012-1797
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- Citations: 156
Vaxillaire M, Simon A, Bonnefond A, et al., 2009, Gene mutations of preproinsulin altering the maturation of insulin and leading to non-autoimmune daibetes in children and type Mody, DIABETES & METABOLISM, Vol: 35, Pages: A2-A2, ISSN: 1262-3636
Rutter GA, 2009, Regulating Glucagon Secretion: Somatostatin in the Spotlight, DIABETES, Vol: 58, Pages: 299-301, ISSN: 0012-1797
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- Citations: 23
Rutter GA, Leclerc I, 2009, The AMP-regulated kinase family: Enigmatic targets for diabetes therapy, MOLECULAR AND CELLULAR ENDOCRINOLOGY, Vol: 297, Pages: 41-49, ISSN: 0303-7207
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- Citations: 64
Voronina SG, Barrow SL, Gerasimenko OV, et al., 2009, ATP CHANGES IN PANCREATIC ACINAR CELLS INDUCED BY STIMULATION WITH Ca<SUP>2+</SUP>-RELEASING SECRETAGOGUES AND ACTIVATORS OF ACUTE PANCREATITIS, JOURNAL OF PHYSIOLOGICAL SCIENCES, Vol: 59, Pages: 242-242, ISSN: 1880-6546
Ravier MA, Tsuboi T, Rutter GA, 2008, Imaging a target of Ca<SUP>2+</SUP> signalling: Dense core granule exocytosis viewed by total internal reflection fluorescence microscopy, METHODS, Vol: 46, Pages: 233-238, ISSN: 1046-2023
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- Citations: 17
Sun G, Xavier GD, Riboulet-Chavey A, et al., 2008, Over-expression of constitutively-activated or dominant-negative forms of AIMP-activated protein kinase (AMPK) selectively in the beta cells of transgenic mice exerts opposing effects on glucose tolerance, 44th Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Pages: S202-S202
Xavier GD, McDonald RAA, Loder MK, et al., 2008, TCF7L2 regulates cell proliferation and differentiation in the developing pancreatic epithelium, 44th Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Pages: S17-S17
Pullen TJ, Xavier GD, Kelsey G, et al., 2008, Beta cell specific silencing of the plasma membrane monocarboxylate transporter MCT1 (SLC16A1) is not effected through methylation of its promoter, 44th Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Pages: S195-S195
Sun G, Xavier GDS, Riboulet-Chavey A, et al., 2008, Over-expression of constitutively-activated or dominant-negative forms of AIMP-activated protein kinase (AMPK) selectively in the beta cells of transgenic mice exerts opposing effects on glucose tolerance, DIABETOLOGIA, Vol: 51, Pages: S202-S202, ISSN: 0012-186X
Pullen TJ, Xavier GDS, Kelsey G, et al., 2008, Beta cell specific silencing of the plasma membrane monocarboxylate transporter <i>MCT1</i> (<i>SLC16A1</i>) is not effected through methylation of its promoter, DIABETOLOGIA, Vol: 51, Pages: S195-S195, ISSN: 0012-186X
Xavier GDS, McDonald RAA, Loder MK, et al., 2008, TCF7L2 regulates cell proliferation and differentiation in the developing pancreatic epithelium, DIABETOLOGIA, Vol: 51, Pages: S17-S17, ISSN: 0012-186X
Chimienti F, Wheeler MB, Nicholson TJ, et al., 2008, Single nucleotide polymorphism rs13266634 modifies the zinc transport activity of SLC30A8/ZnT-8 in clonal pancreatic beta cells, Publisher: SPRINGER, Pages: S47-S47, ISSN: 0012-186X
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- Citations: 1
Cunha DA, Hekerman P, Ladriere L, et al., 2008, Initiation and execution of lipotoxic ER stress in pancreatic β-cells, JOURNAL OF CELL SCIENCE, Vol: 121, Pages: 2308-2318, ISSN: 0021-9533
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- Citations: 479
Loder MK, Xavier GD, McDonald A, et al., 2008, TCF7L2 controls insulin gene expression and insulin secretion in mature pancreatic beta-cells, Biochemical-Society-Irish-Area-Section Annual Meeting on Ubiquitin and Ubiquitin-Like Modification in Health and Disease, Pages: 357-359
Genetic studies have linked the risk of Type 2 diabetes with SNPs (single nucleotide polymorphisms) in the gene encoding the Writ signalling-associated transcription factor, TCF7L2 (T-cell factor 7-like 2). The risk alleles have been associated with reduced glucose and GLP-1 (glucagon-like peptide 1)-stimulated insulin secretion. Recent evidence has suggested that inheritance of the at-risk T allele at SNP rs7903146 may increase the expression of TCF7L2 in adult human islets. However, the cellular mechanisms by which changes in TCF7L2 levels may affect insulin secretion are unclear. in the present paper, we describe the use of RNA silencing to investigate the role of TCF7L2 on insulin secretion and gene expression in rodent islets. We find that reduced TCF7L2 expression reduces glucose-simulated insulin secretion and insulin gene expression while slightly potentiating glucose stimulated changes in intracellular free Ca2+ concentrations.
Tarasov AI, Nicolson TJ, Riveline J-P, et al., 2008, A rare mutation in <i>ABCC8/SUR1</i> leading to altered ATP-sensitive K<SUP>+</SUP> channel activity and β-cell glucose sensing is associated with type 2 diabetes in adults, DIABETES, Vol: 57, Pages: 1595-1604, ISSN: 0012-1797
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- Citations: 52
Loder MK, Xavier GDS, McDonald A, et al., 2008, TCF7L2 controls insulin gene expression and insulin secretion in mature pancreatic β-cells, BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 36, Pages: 357-359, ISSN: 0300-5127
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- Citations: 54
Rutter GA, Wong FS, 2008, The pancreatic beta-cell: birth, life and death, Biochemical-Society-Irish-Area-Section Annual Meeting on Ubiquitin and Ubiquitin-Like Modification in Health and Disease, Pages: 267-271
Defective insulin secretion is a hallmark of all forms of diabetes. Whereas Type 1 diabetes has long been known to result from the immune-mediated destruction of beta-cells, Type 2 diabetes appears to involve both loss of beta-cell mass and glucose sensitivity in the face of extrapancreatic insulin resistance. We summarize here the proceedings of a Biochemical Society Focused Meeting, held at the St Thomas campus of King's College London in December 2007, which highlighted recent research advances targeting the beta-cell.
Zatyka M, Bellomo EA, Permutt MA, et al., 2008, Depletion of the WFS1 gene in MIN6 cells reduces the glucose induced cytoplasmic ATP rise and modulates calcium uptake by the endoplasmic reticulum, 67th Annual Meeting of the American-Diabetes-Association, Publisher: AMER DIABETES ASSOC, Pages: A54-A55, ISSN: 0012-1797
Rutter GA, Wong FS, 2008, The pancreatic β-cell:: birth, life and death, BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 36, Pages: 267-271, ISSN: 0300-5127
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- Citations: 4
Rutter GA, Bellomo EA, 2008, Ca2+ signalling: a new route to NAADP., Biochem J, Vol: 411, Pages: e1-e3
NAADP (nicotinic acid-adenine dinucleotide phosphate) is a derivative of NADP (nicotinamide-adenine dinucleotide phosphate), which differs by the presence of a nicotinic acid instead of a nicotinamide moiety. This small structural difference makes NAADP one of the most powerful second messengers known, able to mobilize intracellular Ca2+ in a wide range of cellular models, ranging from invertebrates to mammals. Despite this, our understanding of NAADP homoeostasis, metabolism and physiological action is still limited. A new report by Vasudevan and colleagues in this issue of the Biochemical Journal provides important new data by describing a new synthetic activity in sperm cells which may turn out to represent the most physiologically relevant route to this second messenger.
Diraison F, Ravier MA, Richards SK, et al., 2008, SREBP1 is required for the induction by glucose of pancreatic β-cell genes involved in glucose sensing, JOURNAL OF LIPID RESEARCH, Vol: 49, Pages: 814-822, ISSN: 0022-2275
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- Citations: 25
Meissner T, Otonkoski T, Jiao H, et al., 2008, Exercise-induced hyperinsulinism:: A new disorder caused by promoter-activating mutations in the SLC16A1 gene, EUROPEAN JOURNAL OF PEDIATRICS, Vol: 167, Pages: 365-365, ISSN: 0340-6199
Riveline JP, Vaxillaire M, Fetita LS, et al., 2008, Metabolic consequences of a new ABCC8/SUR1 gene mutation found in adult type 2 diabetic patients and their lineage, Publisher: MASSON EDITEUR, Pages: A78-A78, ISSN: 1262-3636
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- Citations: 1
Nicolson T, Taneja T, Baldwin J, et al., 2008, Functional properties of the common and Type 2 diabetes-associated R325W variant of the vesicular zinc transporter ZnT8, Publisher: WILEY, ISSN: 0742-3071
Barrow SL, Voronina SG, Xavier GDS, et al., 2008, ATP depletion inhibits Ca<SUP>2+</SUP> release, influx and extrusion in pancreatic acinar cells but not pathological Ca<SUP>2+</SUP> responses induced by bile, PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, Vol: 455, Pages: 1025-1039, ISSN: 0031-6768
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- Citations: 34
Loder MK, Xavier GDS, McDonald A, et al., 2008, The role of TCF7L2 in insulin secretion in mature beta cells, Publisher: WILEY, ISSN: 0742-3071
Noordeen NA, Khera T, Xavier GDS, et al., 2008, Regulation of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) gene expression by the Carbohydrate-Responsive Element Binding Protein (ChREBP), Publisher: WILEY, ISSN: 0742-3071
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