Imperial College London
Alternate

ProfessorGuyRutter

Faculty of Medicine, Department of Medicine

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 3340g.rutter Website

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Georgiadou:2020:10.1016/j.ceca.2020.102282,
author = {Georgiadou, E and Rutter, GA},
doi = {10.1016/j.ceca.2020.102282},
journal = {Cell Calcium},
title = {Control by Ca2+ of mitochondrial structure and function in pancreatic β-cells},
url = {http://dx.doi.org/10.1016/j.ceca.2020.102282},
volume = {91},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Mitochondria play a central role in glucose metabolism and the stimulation of insulin secretion from pancreatic β-cells. In this review, we discuss firstly the regulation and roles of mitochondrial Ca2+ transport in glucose-regulated insulin secretion, and the molecular machinery involved. Next, we discuss the evidence that mitochondrial dysfunction in β-cells is associated with type 2 diabetes, from a genetic, functional and structural point of view, and then the possibility that these changes may in part be mediated by dysregulation of cytosolic Ca2+. Finally, we review the importance of preserved mitochondrial structure and dynamics for mitochondrial gene expression and their possible relevance to the pathogenesis of type 2 diabetes.
AU  - Georgiadou,E
AU  - Rutter,GA
DO  - 10.1016/j.ceca.2020.102282
PY  - 2020///
SN  - 0143-4160
TI  - Control by Ca2+ of mitochondrial structure and function in pancreatic β-cells
T2  - Cell Calcium
UR  - http://dx.doi.org/10.1016/j.ceca.2020.102282
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32961506
UR  - http://hdl.handle.net/10044/1/84203
VL  - 91
ER  -
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