Imperial College London
Alternate

ProfessorGuyRutter

Faculty of Medicine, Department of Medicine

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 3340g.rutter Website

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Akalestou:2016:10.1097/MPA.0000000000000585,
author = {Akalestou, E and Christakis, I and Solomou, A and Minnion, J and Rutter, G and Bloom, S},
doi = {10.1097/MPA.0000000000000585},
journal = {Pancreas},
pages = {967--973},
title = {Proglucagon-derived peptides do not significantly affect acute exocrine pancreas in rat},
url = {http://dx.doi.org/10.1097/MPA.0000000000000585},
volume = {45},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objectives: Reports have suggested a link between treatment with glucagon-like peptide 1 (GLP-1) analogues and an increased risk of pancreatitis. Oxyntomodulin, a dual agonist of both GLP-1 and glucagon receptors, is currently being investigated as a potential anti-obesity therapy, but little is known about the pancreatic safety of this approach. The aim of this study was to investigate the acute effect of oxyntomodulin and other proglucagon-derived peptides on the rat exocrine pancreas. Methods: GLP-1, oxyntomodulin, glucagon and exendin-4 were infused into anaesthetised rats to measure plasma amylase concentration changes. Additionally, the effect of each peptide on both amylase release and proliferation in rat pancreatic acinar (AR42J) and primary isolated ductal cells was determined. Results: Plasma amylase did not increase post infusion of individual peptides, compared to vehicle and cholecystokinin (CCK); however, oxyntomodulin inhibited plasma amylase when co-administered with CCK. None of the peptides caused a significant increase in proliferation rate or amylase secretion from acinar and ductal cells. Conclusions: the investigated peptides do not have an acute effect on the exocrine pancreas with regard to proliferation and plasma amylase, when administered individually. Oxyntomodulin appears to be a potent inhibitor of amylase release, potentially making it a safer anti-obesity agent regarding pancreatitis, compared to GLP-1 agonists.
AU  - Akalestou,E
AU  - Christakis,I
AU  - Solomou,A
AU  - Minnion,J
AU  - Rutter,G
AU  - Bloom,S
DO  - 10.1097/MPA.0000000000000585
EP  - 973
PY  - 2016///
SN  - 1536-4828
SP  - 967
TI  - Proglucagon-derived peptides do not significantly affect acute exocrine pancreas in rat
T2  - Pancreas
UR  - http://dx.doi.org/10.1097/MPA.0000000000000585
UR  - http://hdl.handle.net/10044/1/26342
VL  - 45
ER  -
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