Publications

BibTex format

@article{Mehta:2017:10.1038/s41598-017-00397-0,
author = {Mehta, ZB and Johnston, NR and Nguyen-Tu, M-S and Broichhagen, J and Schultz, P and Larner, DP and Leclerc, I and Trauner, D and Rutter, GA and Hodson, DJ},
doi = {10.1038/s41598-017-00397-0},
journal = {Scientific Reports},
title = {Remote control of glucose homeostasis in vivo using photopharmacology},
url = {http://dx.doi.org/10.1038/s41598-017-00397-0},
volume = {7},
year = {2017}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Photopharmacology describes the use of light to precisely deliver drug activity in space and time. Such approaches promise to improve drug specificity by reducing off-target effects. As a proof-of-concept, we have subjected the fourth generation photoswitchable sulfonylurea JB253 to comprehensive toxicology assessment, including mutagenicity and maximum/repeated tolerated dose studies, as well as in vivo testing in rodents. Here, we show that JB253 is well-tolerated with minimal mutagenicity and can be used to optically-control glucose homeostasis in anesthetized mice following delivery of blue light to the pancreas. These studies provide the first demonstration that photopharmacology may one day be applicable to the light-guided treatment of type 2 diabetes and other metabolic disease states in vivo in humans.
AU  - Mehta,ZB
AU  - Johnston,NR
AU  - Nguyen-Tu,M-S
AU  - Broichhagen,J
AU  - Schultz,P
AU  - Larner,DP
AU  - Leclerc,I
AU  - Trauner,D
AU  - Rutter,GA
AU  - Hodson,DJ
DO  - 10.1038/s41598-017-00397-0
PY  - 2017///
SN  - 2045-2322
TI  - Remote control of glucose homeostasis in vivo using photopharmacology
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-017-00397-0
UR  - http://hdl.handle.net/10044/1/51877
VL  - 7
ER  -

Download

ProfessorGuyRutter

Contact

Location

Summary

Citation

BibTex format

RIS format (EndNote, RefMan)