Imperial College London

ProfessorGavinScreaton

Faculty of MedicineDepartment of Immunology and Inflammation

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 1190g.screaton Website

 
 
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Assistant

 

Ms Claire Puddephatt +44 (0)20 7594 1190

 
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Location

 

2.15Faculty BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

143 results found

Dejnirattisai W, Jumnainsong A, Onsirisakul N, Fitton P, Vasanawathana S, Limpitikul W, Puttikhunt C, Edwards C, Duangchinda T, Supasa S, Chawansuntati K, Malasit P, Mongkolsapaya J, Screaton Get al., 2010, Cross-Reacting Antibodies Enhance Dengue Virus Infection in Humans, SCIENCE, Vol: 328, Pages: 745-748, ISSN: 0036-8075

Journal article

Freundt EC, Yu L, Goldsmith CS, Welsh S, Cheng A, Yount B, Liu W, Frieman MB, Buchholz UJ, Screaton GR, Lippincott-Schwartz J, Zaki SR, Xu X-N, Baric RS, Subbarao K, Lenardo MJet al., 2010, The Open Reading Frame 3a Protein of Severe Acute Respiratory Syndrome-Associated Coronavirus Promotes Membrane Rearrangement and Cell Death, JOURNAL OF VIROLOGY, Vol: 84, Pages: 1097-1109, ISSN: 0022-538X

Journal article

Newsom-Davis TE, Wang D, Steinman L, Chen PF-T, Wang L-X, Simon AK, Screaton GRet al., 2009, Enhanced Immune Recognition of Cryptic Glycan Markers in Human Tumors, CANCER RESEARCH, Vol: 69, Pages: 2018-2025, ISSN: 0008-5472

Journal article

Li D, Wang L, Yu L, Freundt EC, Jin B, Screaton GR, Xu XNet al., 2009, Ig-like transcript 4 inhibits lipid antigen presentation through direct CD1d interaction, Journal of Immunology, Vol: 2, Pages: 1033-1040

Journal article

Dharmapatni AASSK, Smith MD, Findlay DM, Holding CA, Evdokiou A, Ahern MJ, Weedon H, Chen P, Screaton G, Xu XN, Haynes DRet al., 2009, Elevated expression of caspase-3 inhibitors, survivin and xIAP correlates with low levels of apoptosis in active rheumatoid synovium, ARTHRITIS RESEARCH & THERAPY, Vol: 11, ISSN: 1478-6354

Journal article

Dejnirattisai W, Duangchinda T, Lin C-LS, Vasanawathana S, Jones M, Jacobs M, Malasit P, Xu X-N, Screaton G, Mongkolsapaya Jet al., 2008, A Complex Interplay among Virus, Dendritic Cells, T Cells, and Cytokines in Dengue Virus Infections, JOURNAL OF IMMUNOLOGY, Vol: 181, Pages: 5865-5874, ISSN: 0022-1767

Journal article

Li CK-F, Wu H, Yan H, Ma S, Wang L, Zhang M, Tang X, Temperton NJ, Weiss RA, Brenchley JM, Douek DC, Mongkolsapaya J, Tran B-H, Lin C-LS, Screaton GR, Hou J-L, McMichael AJ, Xu X-Net al., 2008, T cell responses to whole SARS coronavirus in humans, JOURNAL OF IMMUNOLOGY, Vol: 181, Pages: 5490-5500, ISSN: 0022-1767

Journal article

Cooper WA, Kohonen-Corish MRJ, Zhuang L, McCaughan B, Kennedy C, Screaton G, Sutherland RL, Lee C-Set al., 2008, Role and prognostic significance of tumor necrosis factor-related apoptosis-inducing ligand death receptor DR5 in nonsmall-cell lung cancer and precursor lesions, CANCER, Vol: 113, Pages: 135-142, ISSN: 0008-543X

Journal article

Simon AK, Newsom-Davis T, Frayne MEF, Ch'en PF-T, McMichael AJ, Screaton GRet al., 2008, Generation of tumour-rejecting anti-carbohydrate monoclonal antibodies using melanoma modified with Fas ligand, INTERNATIONAL IMMUNOLOGY, Vol: 20, Pages: 525-534, ISSN: 0953-8178

Journal article

Patel VK, Pedro VL, Screaton G, Walters JR, Ghosh Set al., 2008, Peripheral blood from Crohn's disease patients demonstrate both IL-17 expressing CD4+ lymphocytes and IL-17 and interferon-gamma double expressing CD4+ lymphocytes, GASTROENTEROLOGY, Vol: 134, Pages: A508-A508, ISSN: 0016-5085

Journal article

Chen DLN, McMichael AJ, Screaton GR, Xu X-Net al., 2008, Generation and characterisation of CD1d tetramer produced by a lentiviral expression system, JOURNAL OF IMMUNOLOGICAL METHODS, Vol: 330, Pages: 57-63, ISSN: 0022-1759

Journal article

Cox JH, McMichael AJ, Screaton GR, Xu X-Net al., 2007, CTLs target Th cells that acquire bystander MHC class I-peptide complex from APCs, JOURNAL OF IMMUNOLOGY, Vol: 179, Pages: 830-836, ISSN: 0022-1767

Journal article

Chotiyarnwong P, Stewart-Jones GB, Tarry MJ, Dejnirattisai W, Siebold C, Koch M, Stuart DI, Harlos K, Malasit P, Screaton G, Mongkolsapaya J, Jones EYet al., 2007, Humidity control as a strategy for lattice optimization applied to crystals of HLA-A*1101 complexed with variant peptides from dengue virus, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, Vol: 63, Pages: 386-392

Journal article

Simon AK, Jones E, Richards H, Wright K, Betts G, Godkin A, Screaton G, Gallimore Aet al., 2007, Regulatory T cells inhibit Fas ligand-induced innate and adaptive tumour immunity, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 37, Pages: 758-767, ISSN: 0014-2980

Journal article

Simon AK, Jones E, Richards H, Wright K, Betts G, Godkin A, Screaton G, Gallimore Aet al., 2007, Regulatory T cells inhibit Fas ligand-induced innate and adaptive tumour immunity., Eur J Immunol, Vol: 37, Pages: 758-767, ISSN: 0014-2980

CD4+CD25+ regulatory T cells (Treg) are known to influence T cell responses to tumours. Here we have explored the role of Treg in inhibiting not only adaptive, but also innate immune responses to tumours. To this end we used a Fas ligand (FasL)-expressing melanoma cell line in a mouse model. In this system, innate immunity is sufficient to reject the tumour. All mice depleted of Treg and challenged with FasL-expressing melanoma remained tumour-free. Investigation of the underlying cellular effector mechanisms revealed that depletion of Treg enhanced an NK cell response capable of tumour lysis. Furthermore, this initial innate immune response primed mice to make an effective adaptive immune response leading to complete rejection of challenge with the parental melanoma. Both antigen-specific antibody and CD4+ T cells were implicated in protection via adaptive immunity. We conclude that removal of Treg and vaccination with whole tumour cells expressing FasL activates multiple arms of the immune system, leading to efficient tumour rejection. These findings highlight a novel role for FasL in inducing innate immune responses that are normally inhibited by Treg and uncover an adjuvant effect of FasL that can be used to stimulate tumour immunity after depletion of Treg.

Journal article

Kimberley FC, Lobito AA, Siegel RM, Screaton GRet al., 2007, Falling into TRAPS - receptor misfolding in the TNF receptor 1-associated periodic fever syndrome, ARTHRITIS RESEARCH & THERAPY, Vol: 9, ISSN: 1478-6354

Journal article

Rice C, Heinz FX, Kuhn R, Harris E, Fairlie D, Young P, Flamand M, Zinkernagel R, Halstead S, Evans TG, Jans DA, Screaton Get al., 2006, Discussion, Pages: 65-70, ISSN: 1528-2511

Conference paper

Zhuang L, Lee CS, Scolyer RA, McCarthy SW, Zhang XD, Thompson JF, Screaton G, Hersey Pet al., 2006, Progression in melanoma is associated with decreased expression of death receptors for tumor necrosis factor-related apoptosis-inducing ligand, HUMAN PATHOLOGY, Vol: 37, Pages: 1286-1294, ISSN: 0046-8177

Journal article

Lobito AA, Kimberley FC, Muppidi JR, Komarow H, Jackson AJ, Hull KM, Kastner DL, Screaton GR, Siegel RMet al., 2006, Abnormal disulfide-linked oligomerization results in ER retention and altered signaling by TNFR1 mutants in TNFR1-associated periodic fever syndrome (TRAPS), BLOOD, Vol: 108, Pages: 1320-1327, ISSN: 0006-4971

Journal article

Mongkolsapaya J, Duangchinda T, Dejnirattisai W, Vasanawathana S, Avirutnan P, Jairungsri A, Khemnu N, Tangthawornchaikul N, Chotiyarnwong P, Sae-Jang K, Koch M, Jones Y, McMichael A, Xu X, Malasit P, Screaton Get al., 2006, T cell responses in dengue hemorrhagic fever: Are cross-reactive T cells suboptimal?, JOURNAL OF IMMUNOLOGY, Vol: 176, Pages: 3821-3829, ISSN: 0022-1767

Journal article

Chen N, McCarthy C, Drakesmith H, Li DM, Cerundolo V, McMichael AJ, Screaton GR, Xu XNet al., 2006, HIV-1 down-regulates the expression of CD1d via Nef, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 36, Pages: 278-286, ISSN: 0014-2980

Journal article

Young P, Keller T, Padmanabhan RP, Fairlie D, Hibberd M, Rice C, Canard B, Vasudevan S, Screaton G, Harris E, Gu F, Halstead S, Farrar J, Holmes E, Malasit P, Evans TGet al., 2006, Discussion, Pages: 114-119, ISSN: 1528-2511

Conference paper

Chan VSF, Chan KYK, Chen Y, Poon LL, Cheung ANY, Zheng B, Chan KH, Mak W, Ngan HYS, Xu X, Screaton G, Tam PKH, Austyn JM, Chan LC, Yip S-P, Peiris MJ, Peiris MJ, Khoo US, Lin CLet al., 2006, Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection., Nat Genet, Vol: 38, Pages: 38-46

Journal article

Clancy L, Mruk K, Archer K, Woelfel M, Mongkolsapaya J, Screaton G, Lenardo MJ, Chan FKMet al., 2005, Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 102, Pages: 18099-18104, ISSN: 0027-8424

Journal article

Simon AK, Chen P, Frayne M, Newsom-Davis T, Screaton GRet al., 2005, Fas Ligand breaks tolerance to self antigens, induces tumour immunity and helps to generate tumour-rejecting monoclonal antibodies, IMMUNOLOGY, Vol: 116, Pages: 38-38, ISSN: 0019-2805

Journal article

Richards HE, Simon AK, Jones E, Williams AS, Screaton GR, Gallimore Aet al., 2005, Inhibition of innate immune responses to tumours by CD4+CD25+ regulatory T cells, IMMUNOLOGY, Vol: 116, Pages: 36-36, ISSN: 0019-2805

Journal article

Ch'en PFT, Xu XG, Liu XS, Liu Y, Song CJ, Screaton GR, Jin BQ, Xu XNet al., 2005, Characterisation of monoclonal antibodies to the TNF and TNF receptor families, CELLULAR IMMUNOLOGY, Vol: 236, Pages: 78-85, ISSN: 0008-8749

Journal article

Dharmapatni AASSK, Findlay DM, Smith MD, Evdokiou A, Chen P, Screaton GR, Xu XN, Holding C, Haynes DRet al., 2005, Regulating the sensitivity of synovial fibroblasts to trail-induced apoptosis, Annual European Congress of Rheumatology, Publisher: BMJ PUBLISHING GROUP, Pages: 154-154, ISSN: 0003-4967

Conference paper

Daniels RA, Turley H, Kimberley FC, Liu XS, Mongkolsapaya J, Ch'en P, Xu XN, Jin BQ, Pezzella F, Screaton GRet al., 2005, Expression of TRAIL and TRAIL receptors in normal and malignant tissues, CELL RESEARCH, Vol: 15, Pages: 430-438, ISSN: 1001-0602

Journal article

Screaton G, Mongkolsapaya J, 2005, T-cell responses and dengue haemorrhagic fever, Molecular Pathogenesis of Virus Infections, Vol: 64, Pages: 15-22, ISSN: 0081-1394

Journal article

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