Imperial College London

ProfessorGavinScreaton

Faculty of MedicineDepartment of Immunology and Inflammation

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 1190g.screaton Website

 
 
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Assistant

 

Ms Claire Puddephatt +44 (0)20 7594 1190

 
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Location

 

2.15Faculty BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

142 results found

Dong T, Stewart-Jones G, Chen N, Easterbrook P, Xu XN, Papagno L, Appay V, Weekes M, Conlon C, Spina C, Little S, Screaton G, van der Merwe A, Richman DD, McMichael AJ, Jones EY, Rowland-Jones SLet al., 2004, HIV-specific cytotoxic T cells from long-term survivors select a unique T cell receptor, Journal of Experimental Medicine, Vol: 200, Pages: 1547-1557, ISSN: 0022-1007

HIV-specific cytotoxic T lymphocytes (CTL) are important in controlling HIV replication, but the magnitude of the CTL response does not predict clinical outcome. In four donors with delayed disease progression we identified Vβ13.2 T cell receptors (TCRs) with very similar and unusually long β-chain complementarity determining region 3 (CDR3) regions in CTL specific for the immunodominant human histocompatibility leukocyte antigens (HLA)-B8–restricted human immunodeficiency virus-1 (HIV-1) nef epitope, FLKEKGGL (FL8). CTL expressing Vβ13.2 TCRs tolerate naturally arising viral variants in the FL8 epitope that escape recognition by other CTL. In addition, they expand efficiently in vitro and are resistant to apoptosis, in contrast to FL8–specific CTL using other TCRs. Selection of Vβ13.2 TCRs by some patients early in the FL8-specific CTL response may be linked with better clinical outcome.

Journal article

Li DM, Brackenridge S, Screaton GR, 2004, A novel CD45 transcript involving the alternative splicing of a new exon is widely distributed in lymphoid tissues, HUMAN IMMUNOLOGY, Vol: 65, Pages: 1539-1545, ISSN: 0198-8859

Journal article

Kimberley FC, Screaton GR, 2004, Following a TRAIL: Update on a ligand and its five receptors, CELL RESEARCH, Vol: 14, Pages: 359-372, ISSN: 1001-0602

Journal article

Jones E, Golgher D, Simon AK, Dahm-Vicker M, Screaton G, Elliott T, Gallimore Aet al., 2004, The influence of CD25+ cells on the generation of immunity to tumour cell lines in mice., Novartis Found Symp, Vol: 256, Pages: 149-152, ISSN: 1528-2511

CD25+ regulatory T cells comprise 5-10% of CD4+ T cells in naïve mice and have been shown in several in vivo murine models to prevent the induction of autoimmune disease and inflammatory disease. Since T cells, which mediate autoimmunity, can through recognition of self-antigens also target tumour cells, it was postulated that CD25+ regulatory cells would also inhibit the generation of immune responses to rumours. Depletion of these cells using CD25-specific monoclonal antibodies has indeed been shown to promote rejection of several transplantable murine tumour cell lines including melanoma, leukaemia and colorectal carcinoma. Results obtained using these models indicate that in the absence of regulatory cells, CD4+ T cells mediate tumour immunity, although the precise mechanisms through which these cells result in tumour rejection have not yet been elucidated. The target antigens recognized by these CD4+ T cells have also not yet been identified. Immunization of mice with tumour cells in the absence of CD25+ regulatory cells does, however, induce immunity against a variety of different tumour cell lines indicating that the target antigen(s) are shared amongst tumours of distinct histological origins. Since CD25+ regulatory cells have been identified in humans, the possibility that the cells inhibit immune responses to shared rejection antigens expressed by human tumours is worthy of investigation.

Journal article

Rihoskova V, Seemayer CA, Hirth A, Daniels R, Screaton GR, Simmen BR, Michel BA, Gay RE, Gay Set al., 2003, Expression and biological function of Trail and its receptors in rheumatoid arthritis (ra)., 67th Annual Scientific Meeting of the American-College-of-Rheumatology/38th Annual Scientific Meeting of the Association-of-Rheumatology-Health-Professionals, Publisher: WILEY-LISS, Pages: S340-S340, ISSN: 0004-3591

Conference paper

Mongkolsapaya J, Dejnirattisai W, Xu XN, Vasanawathana S, Tangthawornchaikul N, Chairunsri A, Sawasdivorn S, Duangchinda T, Dong T, Rowland-Jones S, Yenchitsomanus PT, McMichael A, Malasit P, Screaton Get al., 2003, Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever, NATURE MEDICINE, Vol: 9, Pages: 921-927, ISSN: 1078-8956

Journal article

Rihoskova V, Daniels R, Seemayer CA, Screaton GR, Gay RE, Gay Set al., 2003, Expression of trail and its receptors in rheumatoid arthritis (RA), Annual European Congress of Rheumatology, Publisher: B M J PUBLISHING GROUP, Pages: 106-107, ISSN: 0003-4967

Conference paper

Brackenridge S, Wilkie AOM, Screaton GR, 2003, Efficient use of a 'dead-end' GA 5 ' splice site in the human fibroblast growth factor receptor genes, EMBO JOURNAL, Vol: 22, Pages: 1620-1631, ISSN: 0261-4189

Journal article

Xu XN, Screaton GR, 2002, MHC/peptide tetramer-based studies of T cell function, JOURNAL OF IMMUNOLOGICAL METHODS, Vol: 268, Pages: 21-28, ISSN: 0022-1759

Journal article

Simon AK, Gallimore A, Jones E, Sawitzki B, Cerundolo V, Screaton GRet al., 2002, Fas ligand breaks tolerance to self-antigens and induces tumor immunity mediated by antibodies, CANCER CELL, Vol: 2, Pages: 315-322, ISSN: 1535-6108

Journal article

Arikan MC, Memmott J, Broderick JA, Lafyatis R, Screaton G, Stamm S, Andreadis Aet al., 2002, Modulation of the membrane-binding projection domain of tau protein: splicing regulation of exon 3, MOLECULAR BRAIN RESEARCH, Vol: 101, Pages: 109-121, ISSN: 0169-328X

Journal article

Cowper AE, Caceres JF, Mayeda A, Screaton GRet al., 2001, Serine-arginine (SR) protein-like factors that antagonize authentic SR proteins and regulate alternative splicing, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 276, Pages: 48908-48914, ISSN: 0021-9258

Journal article

Xu XN, Screaton GR, McMichael AJ, 2001, Virus infections: Escape, resistance, and counterattack, IMMUNITY, Vol: 15, Pages: 867-870, ISSN: 1074-7613

Journal article

Xu XN, Screaton G, 2001, HIV-1 Nef: negative effector of Fas?, NATURE IMMUNOLOGY, Vol: 2, Pages: 384-385, ISSN: 1529-2908

Journal article

Simon AK, Williams O, Mongkolsapaya J, Jin B, Xu XN, Walczak H, Screaton GRet al., 2001, Tumor necrosis factor-related apoptosis-inducing ligand in T cell development: Sensitivity of human thymocytes, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 98, Pages: 5158-5163, ISSN: 0027-8424

Journal article

Simon AK, Williams O, Mongkolsapaya J, Jin B, Xu XN, Walczak H, Screaton GRet al., 2001, Tumor necrosis factor-related apoptosis-inducing ligand in T cell development: sensitivity of human thymocytes., Proc Natl Acad Sci U S A, Vol: 98, Pages: 5158-5163, ISSN: 0027-8424

TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) is a recently identified member of the tumor necrosis factor cytokine superfamily. TRAIL has been shown to induce apoptosis in various tumor cell lines, whereas most primary cells seem to be resistant. These observations have raised considerable interest in the use of TRAIL in tumor therapy. Yet little is known about the physiological function of TRAIL. This is particularly the case in the immune system, where TRAIL has been suggested by some to be involved in target cell killing and lymphocyte death. We have developed a panel of mAbs and soluble proteins to address the role of TRAIL in lymphocyte development. These studies demonstrate activation-induced sensitization of thymocytes to TRAIL-mediated apoptosis and expression of the apoptosis-inducing TRAIL receptors. However, with the use of several model systems, our subsequent experiments rule out the possibility that TRAIL plays a major role in antigen-induced deletion of thymocytes. In contrast to thymocytes, there is no up-regulation of TRAIL receptors in peripheral T cells on activation, which remain resistant to TRAIL. Thus, susceptibility to TRAIL-induced apoptosis is controlled differently by central and peripheral T cells.

Journal article

Xu XN, Purbhoo MA, Chen N, Mongkolsapaya J, Cox JH, Meier UC, Tafuro S, Dunbar PR, Sewell AK, Hourigan CS, Appay V, Cerundolo V, Burrows SR, McMichael A, Screaton GRet al., 2001, A novel approach to antigen-specific deletion of CTL with minimal cellular activation using alpha three domain mutants of MHC class I/peptide complex, Immunity, Vol: 14, Pages: 591-602, ISSN: 1074-7613

Journal article

van Oordt WVH, Newton M, Screaton GR, Caceres JFet al., 2000, Role of SR protein modular domains in alternative splicing specificity in vivo, NUCLEIC ACIDS RESEARCH, Vol: 28, Pages: 4822-4831, ISSN: 0305-1048

Journal article

Arikan MC, Memmott J, Screaton G, Stamm S, Lafyatis R, Andreadis Aet al., 2000, Regulation of alternative splicing of the tau projection domain, MOLECULAR BIOLOGY OF THE CELL, Vol: 11, Pages: 12A-12A, ISSN: 1059-1524

Journal article

Wei ML, Memmott J, Screaton C, Andreadis Aet al., 2000, The splicing determinants of a regulated exon in the axonal MAP tau reside within the exon and in its upstream intron, MOLECULAR BRAIN RESEARCH, Vol: 80, Pages: 207-218, ISSN: 0169-328X

Journal article

Screaton G, Xu XN, 2000, T cell life and death signalling via TNF-receptor family members, CURRENT OPINION IN IMMUNOLOGY, Vol: 12, Pages: 316-322, ISSN: 0952-7915

Journal article

ten Dam GB, Zilch CF, Wallace D, Wieringa B, Beverley PCL, Poels LG, Screaton GRet al., 2000, Regulation of alternative splicing of CD45 by antagonistic effects of SR protein splicing factors, JOURNAL OF IMMUNOLOGY, Vol: 164, Pages: 5287-5295, ISSN: 0022-1767

Journal article

Gao QS, Memmott J, Lafyatis R, Stamm S, Screaton G, Andreadis Aet al., 2000, Complex regulation of tau exon 10, whose missplicing causes frontotemporal dementia, JOURNAL OF NEUROCHEMISTRY, Vol: 74, Pages: 490-500, ISSN: 0022-3042

Journal article

Mongkolsapaya J, Grimes JM, Chen N, Xu XN, Stuart DI, Jones EY, Screaton GRet al., 1999, Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation, NATURE STRUCTURAL BIOLOGY, Vol: 6, Pages: 1048-1053, ISSN: 1072-8368

Journal article

Xu XN, Laffert B, Screaton GR, Kraft M, Wolf D, Kolanus W, Mongkolsapay J, McMichael AJ, Baur ASet al., 1999, Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 189, Pages: 1489-1496, ISSN: 0022-1007

Journal article

Tan RS, Xu XN, Ogg GS, Hansasuta P, Dong T, Rostron T, Luzzi G, Conlon CP, Screaton GR, McMichael AJ, Rowland-Jones Set al., 1999, Rapid death of adoptively transferred T cells in acquired immunodeficiency syndrome, BLOOD, Vol: 93, Pages: 1506-1510, ISSN: 0006-4971

Journal article

Mayeda A, Screaton GR, Chandler SD, Fu XD, Krainer ARet al., 1999, Substrate specificities of SR proteins in constitutive splicing are determined by their RNA recognition motifs and composite pre-mRNA exonic elements, MOLECULAR AND CELLULAR BIOLOGY, Vol: 19, Pages: 1853-1863, ISSN: 0270-7306

Journal article

Bell MV, Cowper AE, Lefranc MP, Bell JI, Screaton GRet al., 1998, Influence of intron length on alternative splicing of CD44, MOLECULAR AND CELLULAR BIOLOGY, Vol: 18, Pages: 5930-5941, ISSN: 0270-7306

Journal article

Mongkolsapaya J, Cowper AE, Xu XN, Morris G, McMichael AJ, Bell JI, Screaton GRet al., 1998, Cutting edge: Lymphocyte inhibitor of TRAIL (TNF-related apoptosis-inducing ligand): A new receptor protecting lymphocytes from the death ligand TRAIL, JOURNAL OF IMMUNOLOGY, Vol: 160, Pages: 3-6, ISSN: 0022-1767

Journal article

Caceres JF, Screaton GR, Krainer AR, 1998, A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm, GENES & DEVELOPMENT, Vol: 12, Pages: 55-66, ISSN: 0890-9369

Journal article

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