Imperial College London

ProfessorGavinScreaton

Faculty of MedicineDepartment of Immunology and Inflammation

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 1190g.screaton Website

 
 
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Assistant

 

Ms Claire Puddephatt +44 (0)20 7594 1190

 
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Location

 

2.15Faculty BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{López-Camacho:2018,
author = {López-Camacho, C and Abbink, P and Larocca, RA and Dejnirattisai, W and Boyd, M and Badamchi-Zadeh, A and Wallace, ZR and Doig, J and Velazquez, RS and Lins, Neto RD and Coelho, DF and Kim, YC and Donald, CL and Owsianka, A and De, Lorenzo G and Kohl, A and Gilbert, SC and Dorrell, L and Mongkolsapaya, J and Patel, AH and Screaton, GR and Barouch, DH and Hill, AVS and Reyes-Sandoval, A},
journal = {Nature Communications},
title = {Rational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors.},
url = {http://hdl.handle.net/10044/1/60302},
volume = {9},
year = {2018}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Zika virus (ZIKV) emerged on a global scale and no licensed vaccine ensures long-lasting anti-ZIKV immunity. Here we report the design and comparative evaluation of four replication-deficient chimpanzee adenoviral (ChAdOx1) ZIKV vaccine candidates comprising the addition or deletion of precursor membrane (prM) and envelope, with or without its transmembrane domain (TM). A single, non-adjuvanted vaccination of ChAdOx1 ZIKV vaccines elicits suitable levels of protective responses in mice challenged with ZIKV. ChAdOx1 prME TM encoding prM and envelope without TM provides 100% protection, as well as long-lasting anti-envelope immune responses and no evidence of in vitro antibody-dependent enhancement to dengue virus. Deletion of prM and addition of TM reduces protective efficacy and yields lower anti-envelope responses. Our finding that immunity against ZIKV can be enhanced by modulating antigen membrane anchoring highlights important parameters in the design of viral vectored ZIKV vaccines to support further clinical assessments.
AU - López-Camacho,C
AU - Abbink,P
AU - Larocca,RA
AU - Dejnirattisai,W
AU - Boyd,M
AU - Badamchi-Zadeh,A
AU - Wallace,ZR
AU - Doig,J
AU - Velazquez,RS
AU - Lins,Neto RD
AU - Coelho,DF
AU - Kim,YC
AU - Donald,CL
AU - Owsianka,A
AU - De,Lorenzo G
AU - Kohl,A
AU - Gilbert,SC
AU - Dorrell,L
AU - Mongkolsapaya,J
AU - Patel,AH
AU - Screaton,GR
AU - Barouch,DH
AU - Hill,AVS
AU - Reyes-Sandoval,A
PY - 2018///
SN - 2041-1723
TI - Rational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors.
T2 - Nature Communications
UR - http://hdl.handle.net/10044/1/60302
VL - 9
ER -