Imperial College London

ProfessorGavinScreaton

Faculty of MedicineDepartment of Immunology and Inflammation

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 1190g.screaton Website

 
 
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Assistant

 

Ms Claire Puddephatt +44 (0)20 7594 1190

 
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Location

 

2.15Faculty BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Yacoub:2016:10.12688/f1000research.6233.1,
author = {Yacoub, S and Mongkolsapaya, J and Screaton, G},
doi = {10.12688/f1000research.6233.1},
title = {Recent advances in understanding dengue},
url = {http://dx.doi.org/10.12688/f1000research.6233.1},
year = {2016}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Dengue is an emerging threat to billions of people worldwide. In the last 20 years, the incidence has increased four-fold and this trend appears to be continuing. Caused by one of four viral serotypes, dengue can present as a wide range of clinical phenotypes with the severe end of the spectrum being defined by a syndrome of capillary leak, coagulopathy, and organ impairment. The pathogenesis of severe disease is thought to be in part immune mediated, but the exact mechanisms remain to be defined. The current treatment of dengue relies on supportive measures with no licensed therapeutics available to date. There have been recent advances in our understanding of a number of areas of dengue research, of which the following will be discussed in this review: the drivers behind the global dengue pandemic, viral structure and epitope binding, risk factors for severe disease and its pathogenesis, as well as the findings of recent clinical trials including therapeutics and vaccines. We conclude with current and future dengue control measures and key areas for future research.
AU - Yacoub,S
AU - Mongkolsapaya,J
AU - Screaton,G
DO - 10.12688/f1000research.6233.1
PY - 2016///
TI - Recent advances in understanding dengue
UR - http://dx.doi.org/10.12688/f1000research.6233.1
ER -