Imperial College London

ProfessorGavinScreaton

Faculty of MedicineDepartment of Immunology and Inflammation

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 1190g.screaton Website

 
 
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Assistant

 

Ms Claire Puddephatt +44 (0)20 7594 1190

 
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Location

 

2.15Faculty BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Barba-Spaeth:2016:10.1038/nature18938,
author = {Barba-Spaeth, G and Dejnirattisai, W and Rouvinski, A and Vaney, MC and Medits, I and Sharma, A and SimonLorière, E and Sakuntabhai, A and Cao-Lormeau, VM and Haouz, A and England, P and Stiasny, K and Mongkolsapaya, J and Heinz, F and Screaton, GR and Rey, F},
doi = {10.1038/nature18938},
journal = {Nature},
pages = {48--53},
title = {Structural basis of potent Zika-dengue virus antibody cross-neutralization},
url = {http://dx.doi.org/10.1038/nature18938},
volume = {536},
year = {2016}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Zika virus is a member of the flavivirus genus that had not been associated with severe disease in humans until the recent outbreaks, when it was linked to microcephaly in newborns in Brazil and to Guillain-Barré syndrome in adults in French Polynesia. Zika virus is related to dengue virus, and we report here that a category of antibodies isolated from dengue patients and targeting a conformational epitope potently neutralize Zika virus. The crystal structure of two of these antibodies in complex with the envelope protein of Zika virus reveals the details of a conserved epitope, which is also the site of interaction of the envelope protein dimer with the precursor prM protein during virus maturation. Comparison of the Zika and dengue virus immunocomplexes provides a lead for rational, epitope-focused design of a universal vaccine capable of eliciting potent cross-neutralizing antibodies to protect against Zika and dengue viruses simultaneously.
AU - Barba-Spaeth,G
AU - Dejnirattisai,W
AU - Rouvinski,A
AU - Vaney,MC
AU - Medits,I
AU - Sharma,A
AU - SimonLorière,E
AU - Sakuntabhai,A
AU - Cao-Lormeau,VM
AU - Haouz,A
AU - England,P
AU - Stiasny,K
AU - Mongkolsapaya,J
AU - Heinz,F
AU - Screaton,GR
AU - Rey,F
DO - 10.1038/nature18938
EP - 53
PY - 2016///
SN - 1476-4687
SP - 48
TI - Structural basis of potent Zika-dengue virus antibody cross-neutralization
T2 - Nature
UR - http://dx.doi.org/10.1038/nature18938
UR - http://hdl.handle.net/10044/1/34051
VL - 536
ER -