Imperial College London

ProfessorGavinScreaton

Faculty of MedicineDepartment of Immunology and Inflammation

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 1190g.screaton Website

 
 
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Assistant

 

Ms Claire Puddephatt +44 (0)20 7594 1190

 
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Location

 

2.15Faculty BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{van:2016:10.1038/ncomms11653,
author = {van, Wilgenburg B and Scherwitzl, I and Hutchinson, EC and Leng, T and Kurioka, A and Kulicke, C and de, Lara C and Cole, S and Vasanawathana, S and Limpitikul, W and Malasit, P and Young, D and Denney, L and STOP-HCV, consortium and Moore, MD and Fabris, P and Giordani, MT and Oo, YH and Laidlaw, SM and Dustin, LB and Ho, LP and Thompson, FM and Ramamurthy, N and Mongkolsapaya, J and Willberg, CB and Screaton, GR and Klenerman, P and Screaton, GR and van, Wilgenburg B and Scherwitzl, I and Hutchinson, E and Leng, T and Kurioka, A and Kulicke, C and Cole, S and de, Lara C and Vasanawathana, S and Limpitikul, W and Malasit, P and Young, D and Denney, L and Moore, M and Fabris, P and Giordani, M and Htun, Oo Y and Laidlaw, S and Dustin, L and Ho, LP and Thompson, F and Ramamurthy, N and Mongkolsapaya, J and Willberg, C and Klenerman, P},
doi = {10.1038/ncomms11653},
journal = {Nature Communications},
title = {MAIT cells are activated during human viral infections},
url = {http://dx.doi.org/10.1038/ncomms11653},
volume = {7},
year = {2016}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Mucosal-associated invariant T (MAIT) cells are abundant in humans and recognize bacterial ligands. Here, we demonstrate that MAIT cells are also activated during human viral infections in vivo. MAIT cells activation was observed during infection with dengue virus, hepatitis C virus and influenza virus. This activation-driving cytokine release and Granzyme B upregulation-is TCR-independent but dependent on IL-18 in synergy with IL-12, IL-15 and/or interferon-α/β. IL-18 levels and MAIT cell activation correlate with disease severity in acute dengue infection. Furthermore, HCV treatment with interferon-α leads to specific MAIT cell activation in vivo in parallel with an enhanced therapeutic response. Moreover, TCR-independent activation of MAIT cells leads to a reduction of HCV replication in vitro mediated by IFN-γ. Together these data demonstrate MAIT cells are activated following viral infections, and suggest a potential role in both host defence and immunopathology.
AU - van,Wilgenburg B
AU - Scherwitzl,I
AU - Hutchinson,EC
AU - Leng,T
AU - Kurioka,A
AU - Kulicke,C
AU - de,Lara C
AU - Cole,S
AU - Vasanawathana,S
AU - Limpitikul,W
AU - Malasit,P
AU - Young,D
AU - Denney,L
AU - STOP-HCV,consortium
AU - Moore,MD
AU - Fabris,P
AU - Giordani,MT
AU - Oo,YH
AU - Laidlaw,SM
AU - Dustin,LB
AU - Ho,LP
AU - Thompson,FM
AU - Ramamurthy,N
AU - Mongkolsapaya,J
AU - Willberg,CB
AU - Screaton,GR
AU - Klenerman,P
AU - Screaton,GR
AU - van,Wilgenburg B
AU - Scherwitzl,I
AU - Hutchinson,E
AU - Leng,T
AU - Kurioka,A
AU - Kulicke,C
AU - Cole,S
AU - de,Lara C
AU - Vasanawathana,S
AU - Limpitikul,W
AU - Malasit,P
AU - Young,D
AU - Denney,L
AU - Moore,M
AU - Fabris,P
AU - Giordani,M
AU - Htun,Oo Y
AU - Laidlaw,S
AU - Dustin,L
AU - Ho,LP
AU - Thompson,F
AU - Ramamurthy,N
AU - Mongkolsapaya,J
AU - Willberg,C
AU - Klenerman,P
DO - 10.1038/ncomms11653
PY - 2016///
SN - 2041-1723
TI - MAIT cells are activated during human viral infections
T2 - Nature Communications
UR - http://dx.doi.org/10.1038/ncomms11653
UR - http://hdl.handle.net/10044/1/34601
VL - 7
ER -