Imperial College London

ProfessorGavinScreaton

Faculty of MedicineDepartment of Immunology and Inflammation

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 1190g.screaton Website

 
 
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Assistant

 

Ms Claire Puddephatt +44 (0)20 7594 1190

 
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Location

 

2.15Faculty BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Fernandez:2017:10.1038/ni.3849,
author = {Fernandez, E and Dejnirattisai, W and Cao, B and Scheaffer, SM and Supasa, P and Wongwiwat, W and Esakky, P and Drury, A and Mongkolsapaya, J and Moley, KH and Mysorekar, IU and Screaton, GR and Diamond, MS},
doi = {10.1038/ni.3849},
journal = {Nature Immunology},
pages = {1261--1269},
title = {Human antibodies to the dengue virus E-dimer epitope have therapeutic activity against Zika virus infection.},
url = {http://dx.doi.org/10.1038/ni.3849},
volume = {18},
year = {2017}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - The Zika virus (ZIKV) epidemic has resulted in congenital abnormalities in fetuses and neonates. Although some cross-reactive dengue virus (DENV)-specific antibodies can enhance ZIKV infection in mice, those recognizing the DENV E-dimer epitope (EDE) can neutralize ZIKV infection in cell culture. We evaluated the therapeutic activity of human monoclonal antibodies to DENV EDE for their ability to control ZIKV infection in the brains, testes, placentas, and fetuses of mice. A single dose of the EDE1-B10 antibody given 3 d after ZIKV infection protected against lethality, reduced ZIKV levels in brains and testes, and preserved sperm counts. In pregnant mice, wild-type or engineered LALA variants of EDE1-B10, which cannot engage Fcg receptors, diminished ZIKV burden in maternal and fetal tissues, and protected against fetal demise. Because neutralizing antibodies to EDE have therapeutic potential against ZIKV, in addition to their established inhibitory effects against DENV, it may be possible to develop therapies that control disease caused by both viruses.
AU - Fernandez,E
AU - Dejnirattisai,W
AU - Cao,B
AU - Scheaffer,SM
AU - Supasa,P
AU - Wongwiwat,W
AU - Esakky,P
AU - Drury,A
AU - Mongkolsapaya,J
AU - Moley,KH
AU - Mysorekar,IU
AU - Screaton,GR
AU - Diamond,MS
DO - 10.1038/ni.3849
EP - 1269
PY - 2017///
SN - 1529-2908
SP - 1261
TI - Human antibodies to the dengue virus E-dimer epitope have therapeutic activity against Zika virus infection.
T2 - Nature Immunology
UR - http://dx.doi.org/10.1038/ni.3849
UR - http://hdl.handle.net/10044/1/51888
VL - 18
ER -