Imperial College London

ProfessorGavinScreaton

Faculty of MedicineDepartment of Immunology and Inflammation

Visiting Professor
 
 
 
//

Contact

 

+44 (0)20 7594 1190g.screaton Website

 
 
//

Assistant

 

Ms Claire Puddephatt +44 (0)20 7594 1190

 
//

Location

 

2.15Faculty BuildingSouth Kensington Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Abbink:2018:10.1038/s41591-018-0056-0,
author = {Abbink, P and Larocca, RA and Dejnirattisai, W and Peterson, R and Nkolola, JP and Borducchi, EN and Supasa, P and Mongkolsapaya, J and Screaton, GR and Barouch, DH},
doi = {10.1038/s41591-018-0056-0},
journal = {Nature Medicine},
pages = {721--723},
title = {Therapeutic and protective efficacy of a dengue antibody against Zika infection in Rhesus monkeys},
url = {http://dx.doi.org/10.1038/s41591-018-0056-0},
volume = {24},
year = {2018}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Strategies to treat Zika virus (ZIKV) infection in dengue virus (DENV) endemic areas are urgently needed. Here we show that a DENV-specific antibody against the E-dimer epitope (EDE) potent ly cross-neutralizes ZIKV and provides robust therapeutic efficacy as well as prophylactic efficacy against ZIKV in rhesus monkeys. Viral escape was not detected, suggesting a relatively high bar to escape. These data demonstrate the potential for antibody-based therapy and prevention of ZIKV.
AU - Abbink,P
AU - Larocca,RA
AU - Dejnirattisai,W
AU - Peterson,R
AU - Nkolola,JP
AU - Borducchi,EN
AU - Supasa,P
AU - Mongkolsapaya,J
AU - Screaton,GR
AU - Barouch,DH
DO - 10.1038/s41591-018-0056-0
EP - 723
PY - 2018///
SN - 1078-8956
SP - 721
TI - Therapeutic and protective efficacy of a dengue antibody against Zika infection in Rhesus monkeys
T2 - Nature Medicine
UR - http://dx.doi.org/10.1038/s41591-018-0056-0
UR - http://hdl.handle.net/10044/1/58680
VL - 24
ER -