Imperial College London

Dr Guy-Bart Stan

Faculty of EngineeringDepartment of Bioengineering

Reader in Engineering Design for Synthetic Biology
 
 
 
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Contact

 

+44 (0)20 7594 6375g.stan Website

 
 
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Location

 

B703Royal School of MinesSouth Kensington Campus

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Summary

 

Summary

Dr Guy-Bart Stan is the Head of the Control Engineering Synthetic Biology group and an academic staff member of the Department of Bioengineering and the Centre for Synthetic Biology and Innovation.

He is Co-Director of Research, a member of the Department of Bioengineering Research Committee, of the Equality and Departmental Culture Committee (EDCC), and of the Faculty of Engineering Research Committee.

Guy-Bart’s research publications can be found at the tab above, or on Google Scholar

NEWS

Just announced: 3D Biosynthetic Printing project funded as part of the first Imperial's Excellence Fund for Frontier Research.

We have received highly-competitive research funding in the first ever round of Imperial's new Excellence Fund for Frontier Research (EFFR). Our project in collaboration with John Heap (Department of Life Sciences) and Connor Myant (Dyson School of Design Engineering) will develop a novel technology for 3D printing with synthetic biology.

Openings


Two PDRA positions (one theory, one experimental): Genetically-encoded RNA-based circuits for synthetic biology and nanotechnological applications

We are looking for two Research Associates to work on a project developing genetically-encoded RNA-based circuits for synthetic biology and nanotechnological applications. Such circuits will combine the modularity, designability and low genetic burden of nucleic-acid systems with the flexibility of genetic circuits that can operate continuously and autonomously. The post holder will work closely with Dr Guy-Bart Stan, Dr Thomas Ouldridge and their groups, http://www.bg.ic.ac.uk/research/g.stan/group and http://www.imperial.ac.uk/principles-of-biomolecular-systems/.

PDRA 1 (experimental)

Initially, the work will focus on genetic encoding and production of individual circuit components in vitro. Subsequently, the appointee will combine these individual genetically-encoded components into functional networks and feedback control architectures in vitro in collaboration with PDRA 2. Finally, the appointee will demonstrate the operation of these motifs in E. coli.

We seek a highly motivated individual in possession of a PhD or equivalent demonstrating expertise in synthetic biology, molecular microbiology, systems biology, cellular engineering or nucleic acid nanotechnology. Postdoctoral experience in a synthetic biology or related lab would be beneficial.

The ideal candidate will have expertise in E. coli synthetic biology and/or engineering of cell-free molecular systems. He or she will be proficient in genetic engineering, including designing and cloning genes using next generation cloning methods (e.g. Gibson, Golden Gate, BASIC, etc.). Experience of standard molecular biology techniques and molecular engineering are essential. The post is funded by the Engineering and Physical Sciences Research Council (EPSRC).

For full details and the application form, please visit this page.

PDRA 2 (theory)

The appointee will explore the design principles of nucleic-acid based control architectures functioning in an environment of continuous component turnover and potential leak reactions. Subsequently, these findings will be used to develop functional RNA-based systems in vitro and in E. coli, in collaboration with PDRA 1.

We seek a highly motivated individual to fill this post, in possession of a PhD or equivalent demonstrating expertise in the analysis of deterministic and/or stochastic dynamical systems. The ideal candidate would show the ability to investigate such systems both analytically and through numerical methods and/or simulation, and would previously have developed computational tools for the use of collaborators. In addition, experience in the modelling of biomolecular systems, knowledge of the principles of feedback control, and understanding of nucleic-acid-based nanotechnology would be beneficial. The post is funded by the UK Engineering and Physical Sciences Research Council (EPSRC).

For full details and the application form, please visit this page.

JOINING OUR GROUP

There are always positions available for excellent prospective PhD students and postdoctoral staff. Please contact Dr Stan directly if you wish to apply for a position in the area of biological systems design and control and/or synthetic biology.

Joining as a PostDoctoral Research Associate

If you are a highly motivated and dynamic post-doc with experience in synthetic biology, or modelling, design or control of biological systems and you are looking to join the Stan Group, please email us with your CV.

List of PostDoctoral Fellowships

If you would like to apply for a PostDoctoral Fellowship to work in my group, this list of PostDoctoral Fellowships might be useful. In particular, if you want to conduct your own research, which is aligned with the core research work in my group, I can sponsor you for an Imperial College Research Fellowship for 3 years. Imperial College's prestigious Research Fellowships financially supports the brightest and very best early career researchers from across the world, providing a level of commitment and support that is rare from a UK university. We are also welcoming and supporting outstanding postdocs applying for a Marie Sklodowska-Curie Individual Fellowship.

Also, Dr Nick Jones has compiled a list of fellowships that you might also want to consider.

Another list of independent PostDoc funding (in Biology) has been compiled by Dr Dieter Lucas.

Joining as a PhD student

We are currently looking for a highly motivated and dynamic PhD student with a background in (bio)mathematics, (bio)physics, dynamical systems and control, computer science, systems biology, synthetic biology for a new project entitled Optimal synthetic biology designs for simultaneous increase in productivity and growth of engineered bacterial cells. This project will be realised in collaboration with the Ellis Lab.

Information about the Imperial College PhD Scholarship scheme is available here. Additionally, information about all Scholarship Schemes (including a scholarships search tool) is available here. Furthermore, Ph.D. studentships in the Department of Bioengineering are advertised here. Information about the PhD programme in the Department of Bioengineering and how to apply can be found here. For general information on the tuition fees and cost of living in London, please read this link. For other sources of funding you can also look at here and here (BioEngineering funding) and here (fees and financial help). Finally, there are also other PhD scholarship schemes such as for example the Crick PhD Programme.

Please check the College entry requirements carefully before applying.

For support of research-related travel expenses you can check this link.

Our group

 The webpage of my group is available from this link: Control Engineering Synthetic Biology group

Research papers

Want to download my papers? This can be done from my research webpage.

Short Biography

Dr Guy-Bart Stan obtained his PhD in Applied Sciences (Nonlinear Dynamical Systems and Control) from the University of Liege, Belgium under the supervision of Rodolphe Sepulchre. His thesis dealt with the global analysis and synthesis of limit cycle oscillations in networks of interconnected nonlinear dynamical systems, and with the global synchronisation of oscillations in such networks. The obtained results are based upon a generalisation of dissipativity theory to the global asymptotic stability analysis of limit cycles, both in isolated and interconnected nonlinear dynamical systems. The proposed approach allows a generalisation of the feedback oscilation mechanisms observed in the Van der Pol and Fitzhugh-Nagumo oscillator to higher dimensional systems.

From July to September 2008, he was an invited visiting scientist at the Laboratory for Information and Decision Systems of the Massachusetts Institute of Technology, Cambridge, USA (invited by Professor Munther Dahleh). From June to August 2004, he was an invited visiting Ph.D. researcher at the "Laboratoire d'Automatique de Grenoble", INPG-ENSIEG, Grenoble, France (invited by Dr Carlos Canudas-de-Wit).

From January 2006 until December 2009, Dr Stan worked as a Research Associate in the Control Group of the University of Cambridge (U.K.) with support from EPSRC (EP/E02761X/1) (previously support from a European Commission FP6 Marie-Curie Intra-European Fellowship (EIF-FP6 025509 GASO)). From June to December 2005, he worked as Senior DSP Engineer at Philips Applied Technologies, Leuven, Belgium. Until May 2005, he worked in the Nonlinear Systems and Control group at the Systems and Modeling department of the University of Liège with F.N.R.S. (Belgian National Fund for Scientific Research) support.

A more detailed C.V. can be downloaded from here.

Research interests

Dr Stan main research interests are in the areas of Synthetic and Systems Biology, Analysis and Design of Complex Biological Networks, and Nonlinear Systems Analysis and Control.

More details about these research topics and the related publications can be found on our current projects short descriptions and on my research webpage.

Selected Publications

Journal Articles

Oyarzun DA, Stan G-BV, 2013, Synthetic gene circuits for metabolic control: design trade-offs and constraints, Journal of the Royal Society Interface, Vol:10, ISSN:1742-5689

Dalchau N, Baek SJ, Briggs HM, et al., 2011, The circadian oscillator gene GIGANTEA mediates a long-term response of the Arabidopsis thaliana circadian clock to sucrose, Proceedings of the National Academy of Sciences of the United States of America, Vol:108, ISSN:0027-8424, Pages:5104-5109

Dalchau N, Hubbard KE, Robertson FC, et al., 2010, Correct biological timing in Arabidopsis requires multiple light-signaling pathways, Proceedings of the National Academy of Sciences of the United States of America, Vol:107, ISSN:0027-8424, Pages:13171-13176

Stan G-B, Belmudes F, Fonteneau R, et al., 2008, Modelling the influence of activation-induced apoptosis of CD4(+) and CD8(+) T-cells on the immune system response of a HIV-infected patient, IET Systems Biology, Vol:2, ISSN:1751-8849, Pages:94-102

More Publications