Imperial College London
Portrait Picture

Guy-Bart Stan

Faculty of Engineering, Department of Bioengineering

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 6375g.stan Website

 
 
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Location

 

B703Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Borkowski:2016:10.1016/j.mib.2016.07.009,
author = {Borkowski, O and Ceroni, F and Stan, GB and Ellis, T},
doi = {10.1016/j.mib.2016.07.009},
journal = {Current Opinion in Microbiology},
pages = {123--130},
title = {Overloaded and stressed: whole-cell considerations for bacterial synthetic biology.},
url = {http://dx.doi.org/10.1016/j.mib.2016.07.009},
volume = {33},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The predictability and robustness of engineered bacteria depend on the many interactions between synthetic constructs and their host cells. Expression from synthetic constructs is an unnatural load for the host that typically reduces growth, triggers stresses and leads to decrease in performance or failure of engineered cells. Work in systems and synthetic biology has now begun to address this through new tools, methods and strategies that characterise and exploit host-construct interactions in bacteria. Focusing on work in E. coli, we review here a selection of the recent developments in this area, highlighting the emerging issues and describing the new solutions that are now making the synthetic biology community consider the cell just as much as they consider the construct.
AU  - Borkowski,O
AU  - Ceroni,F
AU  - Stan,GB
AU  - Ellis,T
DO  - 10.1016/j.mib.2016.07.009
EP  - 130
PY  - 2016///
SN  - 1879-0364
SP  - 123
TI  - Overloaded and stressed: whole-cell considerations for bacterial synthetic biology.
T2  - Current Opinion in Microbiology
UR  - http://dx.doi.org/10.1016/j.mib.2016.07.009
UR  - http://hdl.handle.net/10044/1/54638
VL  - 33
ER  -
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