Publications
429 results found
THOMPSON GR, MILLER JP, BRESLOW JL, 1988, PLASMA-EXCHANGE PROLONGS SURVIVAL IN HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA (FH), ARTIFICIAL ORGANS, Vol: 12, Pages: 284-284, ISSN: 0160-564X
, 1988, Lipid-lowering drugs., Lancet, Vol: 1, Pages: 597-598, ISSN: 0140-6736
THOMPSON GR, 1988, LIPID-LOWERING DRUGS, LANCET, Vol: 1, Pages: 597-597, ISSN: 0140-6736
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- Citations: 3
ALLAWAY SL, RITCHIE CD, ROBINSON D, et al., 1988, DETECTION OF ALCOHOL-INDUCED FATTY LIVER BY COMPUTERIZED-TOMOGRAPHY, JOURNAL OF THE ROYAL SOCIETY OF MEDICINE, Vol: 81, Pages: 149-151, ISSN: 0141-0768
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- Citations: 10
THOMPSON GR, 1988, LIPID-LOWERING THERAPY IN PERSPECTIVE, BRITISH JOURNAL OF CLINICAL PRACTICE, Vol: 42, Pages: 61-64, ISSN: 0007-0947
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- Citations: 1
THOMPSON GR, 1988, CLINICAL CONSEQUENCES OF HYPERLIPEMIA, JOURNAL OF INHERITED METABOLIC DISEASE, Vol: 11, Pages: 18-28, ISSN: 0141-8955
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- Citations: 4
Thompson GR, Okabayashi K, 1988, Plasma exchange and LDL apheresis., Prog Clin Biol Res, Vol: 255, Pages: 311-316, ISSN: 0361-7742
THOMPSON GR, 1988, NORMAL AND PATHOLOGICAL LIPOPROTEIN METABOLISM, DRUGS, Vol: 36, Pages: 51-54, ISSN: 0012-6667
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- Citations: 3
Thompson GR, 1988, Normal and pathological lipoprotein metabolism., Drugs, Vol: 36 Suppl 3, Pages: 51-54, ISSN: 0012-6667
Lipids are transported in plasma as lipoproteins, and an increase in 1 or more classes of lipoprotein underlies all forms of hyperlipidaemia. Physiological influences on lipoprotein metabolism are age, gender, bodyweight, diet and exercise. Pathological influences include genetic abnormalities, endocrine dysfunction, renal impairment and iatrogenic effects. Three inherited forms of hyperlipidaemia which predispose to atherosclerosis are familial hypercholesterolaemia (FH), type III hyperlipoproteinaemia and familial combined hyperlipidaemia (FCH), each of which has its own distinctive metabolism defect. In FH, deficiency of low density lipoprotein (LDL) receptors results in the accumulation in plasma of LDL-cholesterol because of a reduction in the receptor-mediated component of LDL catabolism. In type III hyperlipoproteinaemia, the presence of an abnormal apo E isoform (apo E2) in remnant particles leads to their accumulation in plasma, through nonrecognition by remnant receptors and a consequent reduced rate of hepatic uptake. In contrast, there is no primary catabolic defect in FCH, in which increased levels of very low density lipoprotein (VLDL) and LDL are largely the result of increased synthesis.
Thompson GR, 1988, Clinical consequences of hyperlipidaemia., J Inherit Metab Dis, Vol: 11 Suppl 1, Pages: 18-28, ISSN: 0141-8955
Hyperlipidaemia is a common and important clinical entity which frequently has a genetic basis. The chief features of severe hypertriglyceridaemia are eruptive xanthomata and acute pancreatitis, whereas most forms of hypercholesterolaemia are associated with premature coronary heart disease. This applies especially to familial hypercholesterolaemia, which is also characterized by tendon xanthomata. Better recognition of hyperlipidaemia allied to recent improvements in treatment should help reduce the frequency of its disabling and sometimes fatal consequences.
Thompson GR, 1987, Genetic and environmental determinants of plasma lipoproteins relevant to coronary heart disease., Br J Clin Pract Suppl, Vol: 54, Pages: 47-53, ISSN: 0262-8767
SHEPHERD J, BETTERIDGE DJ, DURRINGTON P, et al., 1987, STRATEGIES FOR REDUCING CORONARY HEART-DISEASE AND DESIRABLE LIMITS FOR BLOOD LIPID CONCENTRATIONS - GUIDELINES OF THE BRITISH-HYPERLIPEMIA-ASSOCIATION, BRITISH MEDICAL JOURNAL, Vol: 295, Pages: 1245-1246, ISSN: 0959-8138
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- Citations: 123
THOMPSON GR, 1987, CARDIAC-CATHETERIZATION IN HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA, ATHEROSCLEROSIS, Vol: 66, Pages: 173-173, ISSN: 0021-9150
THOMPSON GR, TENG B, SNIDERMAN AD, 1987, KINETICS OF LDL SUBFRACTIONS, AMERICAN HEART JOURNAL, Vol: 113, Pages: 514-517, ISSN: 0002-8703
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- Citations: 17
THOMPSON GR, 1987, EVIDENCE THAT LOWERING SERUM-LIPIDS FAVORABLY INFLUENCES CORONARY HEART-DISEASE, QUARTERLY JOURNAL OF MEDICINE, Vol: 62, Pages: 87-95, ISSN: 0033-5622
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- Citations: 13
KANO M, KOIZUMI J, JADHAV A, et al., 1987, PLASMA-EXCHANGE AND LOW-DENSITY-LIPOPROTEIN APHERESIS IN WATANABE HERITABLE HYPERLIPIDEMIC RABBITS, ARTERIOSCLEROSIS, Vol: 7, Pages: 256-261, ISSN: 0276-5047
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- Citations: 21
Thompson GR, Kano M, Reeve J, 1987, Turnover and interconversion of LDL sub-fractions., Adv Exp Med Biol, Vol: 210, Pages: 105-109, ISSN: 0065-2598
Thompson G, 1986, Clinical pharmacology. New hopes for the treatment of coronary heart disease., Nature, Vol: 324, ISSN: 0028-0836
THOMPSON GR, 1986, PATHOGENESIS OF ATHEROSCLEROSIS, PHARMACY INTERNATIONAL, Vol: 7, Pages: 276-279, ISSN: 0167-3157
SULLIVAN DR, SANDERS TAB, TRAYNER IM, et al., 1986, PARADOXICAL ELEVATION OF LDL APOPROTEIN-B LEVELS IN HYPERTRIGLYCERIDEMIC PATIENTS AND NORMAL SUBJECTS INGESTING FISH OIL, ATHEROSCLEROSIS, Vol: 61, Pages: 129-134, ISSN: 0021-9150
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- Citations: 181
THOMPSON GR, FORD J, JENKINSON M, et al., 1986, EFFICACY OF MEVINOLIN AS ADJUVANT THERAPY FOR REFRACTORY FAMILIAL HYPERCHOLESTEROLEMIA, QUARTERLY JOURNAL OF MEDICINE, Vol: 60, Pages: 803-811, ISSN: 0033-5622
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- Citations: 58
TENG B, SNIDERMAN AD, SOUTAR AK, et al., 1986, METABOLIC BASIS OF HYPERAPOBETALIPOPROTEINEMIA - TURNOVER OF APOLIPOPROTEIN-B IN LOW-DENSITY-LIPOPROTEIN AND ITS PRECURSORS AND SUBFRACTIONS COMPARED WITH NORMAL AND FAMILIAL HYPERCHOLESTEROLEMIA, JOURNAL OF CLINICAL INVESTIGATION, Vol: 77, Pages: 663-672, ISSN: 0021-9738
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- Citations: 261
KNIGHT BL, THOMPSON GR, SOUTAR AK, 1986, BINDING AND DEGRADATION OF HEAVY AND LIGHT SUBFRACTIONS OF LOW-DENSITY-LIPOPROTEIN BY CULTURED FIBROBLASTS AND MACROPHAGES, ATHEROSCLEROSIS, Vol: 59, Pages: 301-306, ISSN: 0021-9150
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- Citations: 19
Thompson GR, Trayner IA, Allaway SL, et al., 1986, Hyperapobetalipoproteinaemia: an emerging risk factor for atherosclerosis., Monogr Atheroscler, Vol: 14, Pages: 129-131, ISSN: 0077-099X
Thompson GR, Jadhav A, 1986, Control of plasma HDL levels after plasmapheresis., Adv Exp Med Biol, Vol: 201, Pages: 127-135, ISSN: 0065-2598
Thompson G, Sapsford R, 1985, Coronary artery bypass grafting and hyperlipidaemia., Br Heart J, Vol: 53, Pages: 237-239, ISSN: 0007-0769
Postiglione A, Thompson GR, 1985, Experience with plasma-exchange in homozygous familial hypercholesterolaemia., Prog Clin Biol Res, Vol: 188, Pages: 213-220, ISSN: 0361-7742
Reduction of plasma cholesterol and apolipoprotein B concentrations can be expected and may appear to slow the rate of progression of the atherosclerotic process (Thompson, 1980). The usefulness of plasma exchange to the treatment of homozygous FH patients has been extended recently by Stoffel et al. (1981), who perfused plasma through an on-line anti-LDL sepharose column, which selectively removes LDL. Having theoretical advantages over plasma-exchange, this procedure avoids the loss of HDL and of other important plasma proteins. In short, plasma-exchange has proved to be a remarkably safe, well tolerated and effective means of treating homozygous FH.
CREA F, VONARNIM T, ALLWORK SP, et al., 1985, FAILURE OF EXPERIMENTAL ATHEROSCLEROSIS TO SENSITIZE CORONARY-ARTERIES TO SPASM IN HYPERCHOLESTEROLEMIC RABBITS, AMERICAN HEART JOURNAL, Vol: 109, Pages: 491-497, ISSN: 0002-8703
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- Citations: 8
THOMPSON GR, SAPSFORD R, 1985, CORONARY-ARTERY BYPASS-GRAFTING AND HYPERLIPEMIA - REPLY, BRITISH HEART JOURNAL, Vol: 54, Pages: 453-453, ISSN: 0007-0769
SUGRUE DD, TRAYNER I, THOMPSON GR, et al., 1985, CORONARY-ARTERY DISEASE AND HEMOSTATIC VARIABLES IN HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA, BRITISH HEART JOURNAL, Vol: 53, Pages: 265-268, ISSN: 0007-0769
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- Citations: 30
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