Imperial College London
Alternate

Emeritus ProfessorGilbertThompson

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Emeritus Professor of Clinical Lipidology
 
 
 
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Contact

 

g.thompson CV

 
 
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Location

 

S230Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

429 results found

THOMPSON GR, MILLER JP, BRESLOW JL, 1985, IMPROVED SURVIVAL OF PATIENTS WITH HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA TREATED WITH PLASMA-EXCHANGE, BMJ-BRITISH MEDICAL JOURNAL, Vol: 291, Pages: 1671-1673, ISSN: 1756-1833

Journal article

Sanders TA, Sullivan DR, Reeve J, Thompson GRet al., 1985, Triglyceride-lowering effect of marine polyunsaturates in patients with hypertriglyceridemia., Arteriosclerosis, Vol: 5, Pages: 459-465, ISSN: 0276-5047

Twenty male patients with primary hypertriglyceridemia were treated for 4 weeks with daily supplements (15 g) of oil, which provided approximately 6 g of polyunsaturated fatty acid (PUFA) either of fish or of vegetable origin. Total plasma cholesterol concentrations were unaffected, but both types of supplement increased high density lipoprotein-3 (HDL3) cholesterol concentrations. The fish, but not the vegetable, oil supplement led to a decrease in plasma triglyceride concentrations. Very low density lipoprotein (VLDL), fatty acid composition, and VLDL triglyceride kinetics were subsequently studied in five patients (four male, one female) before and after 4 weeks of therapy with 15 g of the same fish oil. The fish oil led to increases in the proportion of eicosapentaenoic acid in both the VLDL triglyceride and phospholipid fractions, but the increase was greater in the latter. In contrast, the proportion of docosahexanoic acid was increased only in the VLDL triglycerides. The decrease in plasma triglyceride concentrations that occurred with fish-oil therapy was accompanied by a reduction in the absolute catabolic rate of VLDL triglyceride, implying a concomitant change in synthetic rate; the fractional catabolic rate of VLDL triglyceride was unaltered. It is suggested that polyunsaturated fatty acids of marine origin may be therapeutically useful for hypertriglyceridemia.

Journal article

FFRENCHCONSTANT CK, SPENGEL FA, THOMPSON GR, 1985, HYPERLIPEMIA AND PREMATURE CORONARY-ARTERY DISEASE ASSOCIATED WITH SEX-CHANGE IN A FEMALE, POSTGRADUATE MEDICAL JOURNAL, Vol: 61, Pages: 61-63, ISSN: 0032-5473

Journal article

Thompson G, 1984, Apoproteins: determinants of lipoprotein metabolism and indices of coronary risk., Br Heart J, Vol: 51, Pages: 585-588, ISSN: 0007-0769

Journal article

Thompson G, 1984, Fat absorption and metabolism., Gastroenterol Jpn, Vol: 19, Pages: 251-259, ISSN: 0435-1339

This review spans almost 20 years during which the author's initial interest in the hypolipidaemia of patients with steatorrhoea eventually led him to treat hyperlipidaemia by deliberately inducing malabsorption of cholesterol and bile acids. Before discussing malabsorption, however, it is necessary to first consider the normal physiology of fat absorption and metabolism. This process can be divided into various phases as summarised below: The intraluminal phase, involves lipolysis and micellar solubilisation of dietary fat; The mucosal phase, involves uptake of micellar lipids and their subsequent re-esterification; The lymphatic phase, involves chylomicron formation and secretion into lymph; and The catabolic phase, which involves the peripheral hydrolysis of chylomicrons, the uptake of remnant particles by the liver and the subsequent recycling and exchange of lipids and apoproteins among the various plasma lipoproteins.

Journal article

THOMPSON GR, TENG B, SNIDERMAN AD, 1984, PREFERENTIAL CATABOLISM OF LIGHT LDL BY THE RECEPTOR-MEDIATED PATHWAY, CIRCULATION, Vol: 70, Pages: 268-268, ISSN: 0009-7322

Journal article

ROWE IF, SOUTAR AK, TRAYNER IM, THOMPSON GR, PEPYS MBet al., 1984, CIRCULATING HUMAN C-REACTIVE PROTEIN BINDS VERY LOW-DENSITY LIPOPROTEINS, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 58, Pages: 237-244, ISSN: 0009-9104

Journal article

THOMPSON GR, TENG B, SNIDERMAN AD, 1984, PREFERENTIAL CATABOLISM OF LIGHT LDL BY THE RECEPTOR-MEDIATED PATHWAY, ARTERIOSCLEROSIS, Vol: 4, Pages: A560-A560, ISSN: 0276-5047

Journal article

ROWE IF, SOUTAR AK, TRAYNER IM, THOMPSON GR, PEPYS MBet al., 1984, HUMAN C-REACTIVE PROTEIN BINDS CIRCULATING VERY LOW-DENSITY LIPOPROTEINS, CLINICAL SCIENCE, Vol: 66, Pages: P45-P46, ISSN: 0143-5221

Journal article

Thompson GR, Teng B, Sniderman AD, 1984, Turnover of apoB in low density lipoprotein sub-fractions., Agents Actions Suppl, Vol: 16, Pages: 121-125, ISSN: 0379-0363

Journal article

ANGEL A, THANABALASINGHAM S, REICHL D, PFLUG JJ, THOMPSON GR, MYANT NBet al., 1984, EFFECTS OF STARVATION AND PLASMA-EXCHANGE ON LECITHIN - CHOLESTEROL ACYLTRANSFERASE ACTIVITY AND CHOLESTEROL EFFLUX IN CHOLESTEROL-FED PIGS, RESEARCH IN EXPERIMENTAL MEDICINE, Vol: 184, Pages: 231-242, ISSN: 0300-9130

Journal article

MURPHY MB, SUGRUE D, TRAYNER I, KAUFMAN S, YASUHARA H, DOLLERY CT, THOMPSON GRet al., 1984, EFFECTS OF SHORT-TERM BETA-ADRENORECEPTOR BLOCKADE ON SERUM-LIPIDS AND LIPOPROTEINS IN PATIENTS WITH HYPERTENSION OR CORONARY-ARTERY DISEASE, BRITISH HEART JOURNAL, Vol: 51, Pages: 589-594, ISSN: 0007-0769

Journal article

Thompson G, Soutar A, 1983, Genetic polymorphism and plasma lipoproteins.

Other

RIBEIRO P, WALESBY R, EDMONDSON S, JADHAV AV, TRAYNER I, OAKLEY CM, THOMPSON GRet al., 1983, COLLAGEN CONTENT OF ATHEROSCLEROTIC ARTERIES IS HIGHER IN SMOKERS THAN IN NON-SMOKERS, LANCET, Vol: 1, Pages: 1070-1073, ISSN: 0140-6736

Journal article

ALLEN JM, THOMPSON GR, MYANT NB, 1983, NORMAL ADRENOCORTICAL-RESPONSE TO ADRENOCORTICOTROPIC HORMONE IN PATIENTS WITH HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA, CLINICAL SCIENCE, Vol: 65, Pages: 99-101, ISSN: 0143-5221

Journal article

RIBEIRO P, SHAPIRO LM, GONZALEZ A, THOMPSON GR, OAKLEY CMet al., 1983, CROSS-SECTIONAL ECHOCARDIOGRAPHIC ASSESSMENT OF THE AORTIC ROOT AND CORONARY OSTIAL STENOSIS IN FAMILIAL HYPERCHOLESTEROLEMIA, BRITISH HEART JOURNAL, Vol: 50, Pages: 432-437, ISSN: 0007-0769

Journal article

TENG B, THOMPSON GR, SNIDERMAN AD, FORTE TM, KRAUSS RM, KWITEROVICH POet al., 1983, COMPOSITION AND DISTRIBUTION OF LOW-DENSITY LIPOPROTEIN FRACTIONS IN HYPERAPOBETALIPOPROTEINEMIA, NORMOLIPIDEMIA, AND FAMILIAL HYPERCHOLESTEROLEMIA, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, Vol: 80, Pages: 6662-6666, ISSN: 0027-8424

Journal article

ALLEN JM, SARSON DL, ADRIAN TE, WOOD C, THOMPSON GR, BLOOM SRet al., 1983, EFFECT OF PARTIAL ILEAL BYPASS ON THE GUT HORMONE RESPONSES TO FOOD IN MAN, DIGESTION, Vol: 28, Pages: 191-196, ISSN: 0012-2823

Journal article

VONARNIM T, CREA F, CHIERCHIA S, THOMPSON GR, MASERI Aet al., 1983, EFFECTS OF VASOACTIVE STIMULI ON CORONARY VASCULAR-RESISTANCE IN ISOLATED PERFUSED RABBIT HEARTS - NO VASOSPASTIC RESPONSE TO ERGONOVINE WITH OR WITHOUT ATHEROGENIC DIET, BASIC RESEARCH IN CARDIOLOGY, Vol: 78, Pages: 415-422, ISSN: 0300-8428

Journal article

Thompson G, 1982, PREVENTION OF CORONARY HEART DISEASE, The Lancet, Vol: 319, ISSN: 0140-6736

Journal article

THOMPSON GR, TENG B, SNIDERMAN A, 1982, METABOLIC CONVERSION OF LIGHT TO HEAVY LOW-DENSITY LIPOPROTEIN (LDL) IN SUBJECTS WITH NORMAL AND INCREASED PLASMA LDL-APO-B LEVELS, CIRCULATION, Vol: 66, Pages: 158-158, ISSN: 0009-7322

Journal article

SPENGEL FA, HARDERSSPENGEL KM, THOMPSON GR, 1982, DIETARY AND DRUG-THERAPY OF HYPERLIPIDEMIAS, ERNAHRUNGS UMSCHAU, Vol: 29, Pages: 100-103, ISSN: 0174-0008

Journal article

SPENGEL FA, HARDERSSPENGEL K, DUFFIELD R, WOOD C, MYANT NB, THOMPSON GRet al., 1982, THE EFFECT OF PARTIAL ILEAL BYPASS ON RECEPTOR-MEDIATED UPTAKE AND CATABOLISM OF LOW-DENSITY LIPOPROTEIN IN THE RHESUS-MONKEY, RESEARCH IN EXPERIMENTAL MEDICINE, Vol: 180, Pages: 263-270, ISSN: 0300-9130

Journal article

SPENGEL FA, THOMPSON GR, 1982, RECEPTOR-MEDIATED LOW-DENSITY LIPOPROTEIN CATABOLISM, KLINISCHE WOCHENSCHRIFT, Vol: 60, Pages: 319-325, ISSN: 0023-2173

Journal article

HARDERSPENGEL K, WOOD CB, THOMPSON GR, MYANT NB, SOUTAR AKet al., 1982, DIFFERENCE IN SATURABLE BINDING OF LOW-DENSITY LIPOPROTEIN TO LIVER MEMBRANES FROM NORMOCHOLESTEROLEMIC SUBJECTS AND PATIENTS WITH HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, Vol: 79, Pages: 6355-6359, ISSN: 0027-8424

Journal article

THOMPSON GR, TENG B, SNIDERMAN A, 1982, METABOLIC CONVERSION OF LIGHT TO HEAVY LOW-DENSITY LIPOPROTEIN IN SUBJECTS WITH NORMAL AND INCREASED PLASMA LDL-APO B-LEVELS, ARTERIOSCLEROSIS, Vol: 2, Pages: A425-A425, ISSN: 0276-5047

Journal article

BORYSIEWICZ LK, SOUTAR AK, EVANS DJ, THOMPSON GR, REES AJet al., 1982, RENAL-FAILURE IN FAMILIAL LECITHIN - CHOLESTEROL ACYLTRANSFERASE DEFICIENCY, QUARTERLY JOURNAL OF MEDICINE, Vol: 51, Pages: 411-426, ISSN: 0033-5622

Journal article

SOUTAR AK, MYANT NB, THOMPSON GR, 1982, THE METABOLISM OF VERY LOW-DENSITY AND INTERMEDIATE DENSITY LIPOPROTEINS IN PATIENTS WITH FAMILIAL HYPERCHOLESTEROLEMIA, ATHEROSCLEROSIS, Vol: 43, Pages: 217-231, ISSN: 0021-9150

Journal article

BORYSIEWICZ LK, SOUTAR A, EVANS DJ, REES AJ, THOMPSON GRet al., 1981, THE RELATIONSHIP OF RENAL ABNORMALITY TO PLASMA-LIPOPROTEINS IN FAMILIAL LECITHIN-CHOLESTEROL ACYL TRANSFERASE (LCAT) DEFICIENCY, QUARTERLY JOURNAL OF MEDICINE, Vol: 50, Pages: 507-508, ISSN: 0033-5622

Journal article

SPENGEL FA, DUFFIELD RGM, JADHAV A, WOOD CB, THOMPSON GRet al., 1981, SUPERIORITY OF PARTIAL ILEAL BYPASS OVER CHOLESTYRAMINE IN REDUCING CHOLESTEROL IN FAMILIAL HYPERCHOLESTEROLEMIA, LANCET, Vol: 2, Pages: 768-770, ISSN: 0140-6736

Journal article

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