Publications
429 results found
Thompson GR, O'Neill F, Seed M, 2002, Why some patients respond poorly to statins and how this might be remedied, EUROPEAN HEART JOURNAL, Vol: 23, Pages: 200-206, ISSN: 0195-668X
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- Citations: 48
Elkeles RS, Dunlop A, Thompson GR, et al., 2002, Coronary calcification and predicted risk of coronary heart disease in asymptomatic men with hypercholesterolaemia, European Journal of Cardiovascular Prevention & Rehabilitation, Vol: 9, Pages: 349-353, ISSN: 1741-8267
Objective To document the relationship between coronary calcification and coronary risk assessed clinically in asymptomatic patients with hypercholesterolaemia. Design Prospective observational study. Setting Health screening clinic. Patients A total of 286 asymptomatic men aged 45–64 with plasma cholesterol ≥ 6.5 mmol/l. Interventions Electron beam computed tomography to measure coronary calcium score. Main outcome measures The Framingham equation was used to separate subjects into groups with either low 10-year risk of coronary artery disease (≤ 10%) or high 10-year risk (≥ 20%). Coronary calcium score was assessed in each group. Results The mean log calcium score was significantly higher in the 97 high-risk men than in the 189 low-risk men (1.58 ± 0.84 versus 1.00 ± 0.85, p < 0.001). Arithmetic means (158 versus 55), and the proportion with a score = 400 (11% versus 2%, p < 0.01) were also greater. However, 27% of the high-risk group had a low calcium score (= 10), which is known to be associated with minimal coronary artery disease assessed by angiography. Conclusions Approximately one quarter of asymptomatic hypercholesterolaemic men aged 45 to 64 who have an estimated risk of coronary heart disease of ≥ 20% in 10 years have minimal coronary calcification. They may therefore represent a subset at lower risk of disease. However, uncertainties about the predictive power of coronary calcification for coronary events must be resolved before electron beam computed tomography can be used to select high-risk patients for primary prevention. © 2002, European Society of Cardiology. All rights reserved.
Thompson GR, Packard CJ, Stone NJ, 2002, Goals of statin therapy: three viewpoints., Curr Atheroscler Rep, Vol: 4, Pages: 26-33, ISSN: 1523-3804
The "lipid hypothesis" is now universally recognized as a law. Few issues in medicine are as completely resolved as the question of whether reducing serum cholesterol increases longevity. However, there are a few questions that remain, and the most important uncertainty is to what extent cholesterol should be reduced. The medical community, in partnership with government and industry, has contributed many excellent trials demonstrating the effects in patients with elevated cholesterol (above the mean). Where should our goal of therapy be? Until data is available from several large, ongoing trials, we do not have a final answer. We asked three investigators, Drs. Gilbert Thompson, Christopher Packard, and Neil Stone, who have all been integrally involved in the accumulation of our present database, to argue three different possible answers.
Thompson GR, Dean J, Wilson PWF, 2002, Dyslipidaemia in clinical practice, ISBN: 9781901865691
Thompson GR, 2002, Familial hypercholesterolaemia, Oxford Textbook of Endocrinology, Pages: 1545-1552, ISBN: 9780192630452
Thompson GR, 2002, Significance of cholesterol absorption: inhibitory role of plant sterols and stanols, Nutrition and Health, Pages: 27-33, ISBN: 9780632058440
Thompson G, 2002, Current and future trends in lipid-regulating therapy, The Year in Dyslipidaemia 2002, Pages: 335-344, ISBN: 9780953733934
O'Neill FH, Patel DD, Knight BL, et al., 2001, Determinants of variable response to statin treatment in patients with refractory familial hypercholesterolemia, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Vol: 21, Pages: 832-837, ISSN: 1079-5642
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- Citations: 49
Thompson GR, 2001, Genetic influence on cholesterol absorption and its therapeutic consequences, Pages: 27-33, ISBN: 9781854632135
Thompson GR, Barter PJ, 2000, Therapeutic approaches to reducing the LDL- and HDL-associated risks of coronary heart disease - Editorial comment, CURRENT OPINION IN LIPIDOLOGY, Vol: 11, Pages: 567-570, ISSN: 0957-9672
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- Citations: 4
Thompson GR, Naoumova RP, 2000, Novel lipid-regulating drugs, EXPERT OPINION ON INVESTIGATIONAL DRUGS, Vol: 9, Pages: 2619-2628, ISSN: 1354-3784
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- Citations: 14
Thompson GR, Barter PJ, 1999, Clinical lipidology at the end of the millennium, CURRENT OPINION IN LIPIDOLOGY, Vol: 10, Pages: 521-526, ISSN: 0957-9672
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- Citations: 26
Thompson GR, 1999, Poor responders to statins: a potential target for stanol esters, International Conference on New Approaches to Dietary Management of Elevated Cholesterol, Publisher: W B SAUNDERS CO LTD, Pages: S114-S117, ISSN: 1520-765X
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- Citations: 2
Thompson GR, 1999, Plant lipids that lower serum cholesterol, EUROPEAN HEART JOURNAL, Vol: 20, Pages: 1527-1529, ISSN: 0195-668X
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- Citations: 4
Thompson GR, 1999, Cholesterol lowering margarine is effective, BRITISH MEDICAL JOURNAL, Vol: 319, Pages: 1200-1201, ISSN: 0959-8138
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- Citations: 1
Thompson GR, 1999, The proving of the lipid hypothesis, CURRENT OPINION IN LIPIDOLOGY, Vol: 10, Pages: 201-205, ISSN: 0957-9672
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- Citations: 9
Rallidis L, Nihoyannopoulos P, Tsitouris G, et al., 1999, Aortic valve involvement in familial heterozygous hypercholesterolaemia: An echocardiographic study, ATHEROSCLEROSIS, Vol: 144, Pages: 141-141, ISSN: 0021-9150
Naoumova RP, O'Neill FH, Dunn S, et al., 1999, Effect of inhibiting HMG-CoA reductase on 7α-hydroxy-4-cholesten-3-one, a marker of bile acid synthesis:: contrasting findings in patients with and without prior up-regulation of the latter pathway, EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Vol: 29, Pages: 404-412, ISSN: 0014-2972
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- Citations: 16
Thompson GR, Grundy SM, 1999, International Conference on New Approaches to Dietary Management of Elevated Cholesterol, Dublin, 28th-30th January 1999: Foreword, European Heart Journal, Supplement, Vol: 1, ISSN: 1520-765X
, 1999, Mortality in treated heterozygous familial hypercholesterolaemia: implications for clinical management. Scientific Steering Committee on behalf of the Simon Broome Register Group., Atherosclerosis, Vol: 142, Pages: 105-112, ISSN: 0021-9150
Clinical management of heterozygous familial hypercholesterolaemia is largely based on evidence from a small number of observational studies and extrapolation from the results of clinical trials of lipid-lowering in patients with polygenic hypercholesterolaemia The objectives of this study were (i) to determine the absolute and relative mortality of patients with treated heterozygous familial hypercholesterolaemia, (ii) to estimate the effect of changes in treatment efficacy on mortality trends over time, and (iii) to examine the implications of these findings for patient management. A cohort of 605 men and 580 women aged 20-79 years with heterozyous familial hypercholesterolaemia were recruited from 21 out-patient lipid clinics in the UK. Patients were followed prospectively from 1980 to 1995 for 8770 person-years. Absolute mortality was calculated, and relative risk was expressed as the ratio of the number of observed deaths to the number expected in the general population of England and Wales. Forty six of the 73 deaths were due to coronary heart disease. In women aged 20-39, despite treatment, the relative risk of a fatal coronary event was increased 125-fold (95% confidence intervals 15-451) and the annual coronary mortality was 0.17%. In men aged 20-39 the relative risk was increased 48-fold (17-105) and the annual coronary mortality was 0.46%. The relative risk decreased with age but the absolute risk increased. For men and women aged 60-79, the annual coronary mortality was 1.1% representing a significant excess mortality for women (relative risk 2.6, 1.3-4.5) but not for men (RR 1.1, 0.5-2.3). Non-coronary mortality was not increased at any age (RR for all ages 0.68, 0.45-0.99). There was a decline in the relative risk for coronary mortality in patients aged 20-59 from an eight-fold (4.8-7.2) increased risk before 1992 to 3.7 (1.6-7.2.) thereafter (P=0.08). The results suggest that the prognosis for patients with heterozygous familial hypercholesterolaemia
Rallidis L, Naoumova RR, Thompson GR, et al., 1998, Extent and severity of atherosclerotic involvement of the aortic valve and root in familial hypercholesterolaemia, HEART, Vol: 80, Pages: 583-590, ISSN: 1355-6037
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- Citations: 81
Naoumova RP, Kim KD, Neuwirth C, et al., 1998, Cholesterol synthesis is increased in mixed hyperlipidaemia, BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM, Vol: 1394, Pages: 146-152, ISSN: 0005-2760
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- Citations: 3
Naoumova RP, O'Neill FH, Neuwirth CK, et al., 1998, Effect of inhibition of HMG-CoA reductase on bile acid synthesis: Contrasting findings in patients with and without partial ileal bypass., ATHEROSCLEROSIS, Vol: 141, Pages: 187-187, ISSN: 0021-9150
Bourbon M, Sun XM, Thompson GR, et al., 1998, Different alleles of the LDL receptor gene with the Pro664Leu mutation in patients with homozygous familial hypercholesterolaemia, ATHEROSCLEROSIS, Vol: 140, Pages: 380-380, ISSN: 0021-9150
Thompson GR, 1998, Introduction, AMERICAN JOURNAL OF CARDIOLOGY, Vol: 82, Pages: 1J-2J, ISSN: 0002-9149
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- Citations: 1
Thompson GR, 1998, Coronary risk factors beyond LDL: Triglyceride-rich lipoproteins, Madeira, 19 April 1997: Foreword, ISSN: 0195-668X
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- Citations: 1
Thompson GR, 1998, Angiographic evidence for the role of triglyceride-rich lipoproteins in progression of coronary artery disease, EUROPEAN HEART JOURNAL, Vol: 19, Pages: H31-H36, ISSN: 0195-668X
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- Citations: 12
Pfohl M, Naoumova RP, Kim KD, et al., 1998, Use of cholesterol precursors to assess changes in cholesterol synthesis under non-steady-state conditions, EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Vol: 28, Pages: 491-496, ISSN: 0014-2972
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- Citations: 17
Berger GMB, Pegoraro RJ, Patel SB, et al., 1998, HMG-CoA reductase is not the site of the primary defect in phytosterolemia, JOURNAL OF LIPID RESEARCH, Vol: 39, Pages: 1046-1054, ISSN: 0022-2275
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- Citations: 11
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