Publications
429 results found
Thompson GR, 1997, Correction: Grand round: Hazards of running a marathon (British Medical Journal (1997) 5 April (1023-1025)), British Medical Journal, Vol: 314, ISSN: 0959-8146
Rallidis LS, Nihoyannopoulos P, Thompson GR, 1997, Diagnosis and management of aortic stenosis in homozygous familial hypercholesterolaemia, Hellenic Journal of Cardiology, Vol: 38, Pages: 316-320, ISSN: 1011-7970
We describe a young woman with homozygous familial hypercholesterolaemia complicated by aortic stenosis, supravalvular aortic atheroma and coronary artery disease. The association of these disorders is common in homozygotes and usually requires surgical intervention with a high operative risk. Our patient underwent successfully widening of the aortic root, aortic valve replacement and aortocoronary bypass grafting, but 2 out of 4 similarly treated patients died.
Enoch P, Akehurst RL, Sheridan P, et al., 1997, Use of statins (multiple letters) [6], British Medical Journal, Vol: 315, Pages: 1615-1620, ISSN: 0959-8146
Haider AW, Andreotti F, Thompson GR, et al., 1996, Serum lipoprotein(a) level is related to thrombin generation and spontaneous intermittent coronary occlusion in patients with acute myocardial infarction, CIRCULATION, Vol: 94, Pages: 2072-2076, ISSN: 0009-7322
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- Citations: 25
Naoumova RP, Marais D, Firth JC, et al., 1996, Atorvastatin augments therapy of homozygous familial hypercholesterolemia by inhibiting upregulation of cholesterol synthesis after apheresis and bile acid sequestrants, CIRCULATION, Vol: 94, Pages: 3410-3410, ISSN: 0009-7322
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- Citations: 4
Hoffer MJV, Niththyananthan S, Naoumova RP, et al., 1996, Apolipoprotein El-Hammersmith (Lys146->Asn;Arg147->Trp), due to a dinucleotide substitution, is associated with early manifestation of dominant type III hyperlipoproteinaemia, ATHEROSCLEROSIS, Vol: 124, Pages: 183-189, ISSN: 0021-9150
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- Citations: 24
Naoumova RP, Cummings MH, Watts GF, et al., 1996, Acute hyperinsulinaemia decreases cholesterol synthesis less in subjects with non-insulin-dependent diabetes mellitus than in non-diabetic subjects (vol 26, pg 332, 1996), EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Vol: 26, Pages: 713-713, ISSN: 0014-2972
Thompson GR, Forbat S, Underwood R, 1996, Electron-beam CT scanning for detection of coronary calcification and prediction of coronary heart disease, QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, Vol: 89, Pages: 565-570, ISSN: 1460-2725
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- Citations: 11
Thompson GR, 1996, Statins and coronary heart disease, LANCET, Vol: 348, Pages: 57-57, ISSN: 0140-6736
Rallidis L, Nihoyannopoulos P, Thompson GR, 1996, Aortic stenosis in homozygous familial hypercholesterolaemia, HEART, Vol: 76, Pages: 84-85, ISSN: 1355-6037
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- Citations: 31
Thompson GR, 1996, Lipid lowering in the young, HEART, Vol: 76, Pages: 1-2, ISSN: 1355-6037
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- Citations: 2
Maher VMG, Thompson GR, 1996, LDL apheresis: Role in the treatment of atherosclerosis, Journal of the Irish Colleges of Physicians and Surgeons, Vol: 25, Pages: 96-99, ISSN: 0374-8405
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- Citations: 1
Naoumova RP, Cummings MH, Watts GF, et al., 1996, Acute hyperinsulinaemia decreases cholesterol synthesis less in subjects with non-insulin-dependent diabetes mellitus than in non-diabetic subjects, EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Vol: 26, Pages: 332-340, ISSN: 0014-2972
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- Citations: 21
Thompson GR, Naoumova RP, Watts GF, 1996, Role of cholesterol in regulating apolipoprotein B secretion by the liver, JOURNAL OF LIPID RESEARCH, Vol: 37, Pages: 439-447, ISSN: 0022-2275
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- Citations: 155
Sidhu PS, Naoumova RP, Maher VM, et al., 1996, The extracranial carotid artery in familial hypercholesterolaemia: relationship of intimal-medial thickness and plaque morphology with plasma lipids and coronary heart disease., J Cardiovasc Risk, Vol: 3, Pages: 61-67, ISSN: 1350-6277
BACKGROUND: Increased frequency of coronary heart disease in familial hypercholesterolaemia is well documented but the association with carotid atherosclerosis is less well established. The ultrasound appearances of the carotid arteries in familial hypercholesterolaemia patients without symptomatic cerebrovascular disease were therefore investigated. METHODS: 59 patients (34 men, 25 women; mean age 46.6 (+/-12.1 years) were prospectively studied using ultrasound examination of the extracranial carotid vessels. Intimal-medial thickness was measured 1 cm proximal to the carotid bulb and morphology of plaque was classified as heterogeneous or homogeneous according to echogenicity. RESULTS: 44 (75.0%) of the patients had carotid artery disease. On stepwise logistic regression, significant predictors of the presence of carotid artery disease were age (P = 0.014), serum triglycerides at time of examination (P = 0.013), coexistent coronary heart disease (P = 0.03) and the cholesterol-years score (CYS) (P = 0.015). Heterogeneous carotid plaque was associated with a higher plasma level of Lp(a) (P = 0.035), TG (P = 0.024), CYS (P = 0.0003) and the presence of CHD (P = 0.001). Matched pairs (n = 22) of patients, where the only variable was Lp(a), showed a marked increase in heterogeneous plaque frequency in those with high Lp(a) levels (P < 0.03). CONCLUSION: Asymptomatic carotid artery disease occurs in a high proportion of familial hypercholesterolaemia patients. The presence of heterogeneous carotid plaque is significantly associated with the presence of coronary heart disease, the calculated cholesterol-years score, hypertriglyceridaemia and raised levels of Lp(a).
Webb JC, Sun XM, McCarthy SN, et al., 1996, Characterization of mutations in the low density lipoprotein (LDL)-receptor gene in patients with homozygous familial hypercholesterolemia, and frequency of these mutations in FH patients in the United Kingdom, JOURNAL OF LIPID RESEARCH, Vol: 37, Pages: 368-381, ISSN: 0022-2275
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- Citations: 46
Naoumova RP, Marais AD, Mountney J, et al., 1996, Plasma mevalonic acid, an index of cholesterol synthesis in vivo, and responsiveness to HMG-CoA reductase inhibitors in familial hypercholesterolaemia, ATHEROSCLEROSIS, Vol: 119, Pages: 203-213, ISSN: 0021-9150
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- Citations: 81
Sidhu PS, Naoumova RP, Maher VMG, et al., 1996, Erratum: The extracranial carotid artery in familial hypercholesterolaemia: Relationship of intimal-medial thickness and plaque morphology with plasma lipids and coronary heart disease (Journal of Cardiovascular Risk (1996) 3 (61-67)), Journal of Cardiovascular Risk, Vol: 3, ISSN: 1350-6277
Naoumova RP, Cummings MH, Watts GF, et al., 1996, Erratum: Acute hyperinsuIinaemia decreases cholesterol synthesis less in subjects with non-insulin-dependent diabetes mellitus than in non-diabetic subjects (European Journal of Clinical Investigation Vol. 26 (1996) (332-340)), European Journal of Clinical Investigation, Vol: 26, ISSN: 0014-2972
Marais AD, Firth JC, Naoumova RP, et al., 1996, The role of HMG-CoA reductase inhibitors in homozygous familial hypercholesterolemia, XII International Symposium of Drugs Affecting Lipid Metabolism (DALM XII), Publisher: KLUWER ACADEMIC PUBL, Pages: 181-186
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- Citations: 2
Watts GF, Cummings MH, Umpleby M, et al., 1995, Erratum: Simvastatin decreases the hepatic secretion of very-low-density lipoprotein apolipoprotein B-100 in heterozygous familial hypercholesterolaemia: Pathophysiological and therapeutic implications (European Journal of Clinical Investigation, Vol. 25: 559-567 (1995)), European Journal of Clinical Investigation, Vol: 25, ISSN: 0014-2972
Thompson GR, Hollyer J, Waters DD, 1995, Percentage change rather than plasma level of LDL-cholesterol determines therapeutic response in coronary heart disease, CURRENT OPINION IN LIPIDOLOGY, Vol: 6, Pages: 386-388, ISSN: 0957-9672
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- Citations: 60
MAHER VMG, GALLAGHER JJ, THOMPSON GR, et al., 1995, DOES THE PRESENCE OF THE 3500 MUTANT APOLIPOPROTEIN B-100 IN LOW-DENSITY-LIPOPROTEIN PARTICLES AFFECT THEIR ATHEROGENICITY, ATHEROSCLEROSIS, Vol: 118, Pages: 105-110, ISSN: 0021-9150
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- Citations: 5
NAOUMOVA RP, PFOHL M, SUSSEKOV A, et al., 1995, ACUTE UP-REGULATION OF CHOLESTEROL-SYNTHESIS BY LDL APHERESIS - EVIDENCE FOR A THRESHOLD EFFECT, CIRCULATION, Vol: 92, Pages: 481-481, ISSN: 0009-7322
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- Citations: 1
NARANG R, NITHTHYANATHAN S, NONIS C, et al., 1995, LIPOPROTEIN(A) MAY HAVE CONTRASTING EFFECTS ON DIFFERENT ASPECTS OF ATHEROSCLEROTIC CORONARY-DISEASE, CIRCULATION, Vol: 92, Pages: 2354-2355, ISSN: 0009-7322
THOMPSON GR, 1995, ANGIOGRAPHIC TRIALS OF LIPID-LOWERING THERAPY - END OF AN ERA, BRITISH HEART JOURNAL, Vol: 74, Pages: 343-347, ISSN: 0007-0769
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- Citations: 27
CUMMINGS MH, WATTS GF, UMPLEBY AM, et al., 1995, INCREASED HEPATIC SECRETION OF VERY-LOW-DENSITY LIPOPROTEIN APOLIPOPROTEIN B-100 IN NIDDM, DIABETOLOGIA, Vol: 38, Pages: 959-967, ISSN: 0012-186X
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- Citations: 114
WATTS GF, CUMMINGS MH, UMPLEBY M, et al., 1995, SIMVASTATIN DECREASES THE HEPATIC SECRETION OF VERY-LOW-DENSITY LIPOPROTEIN APOLIPOPROTEIN B-100 IN HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA - PATHOPHYSIOLOGICAL AND THERAPEUTIC IMPLICATIONS, EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Vol: 25, Pages: 559-567, ISSN: 0014-2972
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- Citations: 52
WATTS GF, NAOUMOVA R, CUMMINGS MH, et al., 1995, DIRECT CORRELATION BETWEEN CHOLESTEROL-SYNTHESIS AND HEPATIC SECRETION OF APOLIPOPROTEIN B-100 IN NORMOLIPIDEMIC SUBJECTS, METABOLISM-CLINICAL AND EXPERIMENTAL, Vol: 44, Pages: 1052-1057, ISSN: 0026-0495
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- Citations: 53
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