83 results found
Bogdanova TI, Saenko VA, Brenner AV, et al., 2018, Comparative Histopathologic Analysis of "Radiogenic" and "Sporadic" Papillary Thyroid Carcinoma: Patients Born Before and After the Chernobyl Accident, THYROID, Vol: 28, Pages: 880-890, ISSN: 1050-7256
Mathieson W, Guljar N, Sanchez I, et al., 2018, Extracting DNA from FFPE Tissue Biospecimens Using User-Friendly Automated Technology: Is There an Impact on Yield or Quality?, BIOPRESERVATION AND BIOBANKING, Vol: 16, Pages: 186-190, ISSN: 1947-5535
Sanchez I, Betsou F, Culot B, et al., 2018, RNA and microRNA Stability in PAXgene-Fixed Paraffin-Embedded Tissue Blocks After Seven Years' Storage, AMERICAN JOURNAL OF CLINICAL PATHOLOGY, Vol: 149, Pages: 536-547, ISSN: 0002-9173
Thomas G, 2018, RADIATION AND THYROID CANCER-AN OVERVIEW., Radiat Prot Dosimetry
It has long been known that the thyroid is a radiosensitive organ. It is the only organ in the body to both take up and bind iodine, and therefore exposure to radioiodine in fallout from nuclear power plants poses an increased danger to the thyroid. Studies following the Chernobyl accident have shown that children are most at risk from the development of thyroid cancer following exposure to radioactive iodine in fallout. This article reviews what we know so far about the type of thyroid cancer induced by radiation, its molecular biology and clinical outcome.
Leonard RCF, Adamson DJA, Bertelli G, et al., 2017, GnRH agonist for protection against ovarian toxicity during chemotherapy for early breast cancer: the Anglo Celtic Group OPTION trial, ANNALS OF ONCOLOGY, Vol: 28, Pages: 1811-1816, ISSN: 0923-7534
McKenzie GAG, McFarlane T, Hing S, et al., 2017, Novel Mutations in Sinonasal Squamous Cell Carcinoma Detected Using Next Generation Sequencing, 106th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology (USCAP), Publisher: NATURE PUBLISHING GROUP, Pages: 329A-329A, ISSN: 0023-6837
McKenzie GAG, McFarlane T, Hing S, et al., 2017, Novel Mutations in Sinonasal Squamous Cell Carcinoma Detected Using Next Generation Sequencing, 106th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology (USCAP), Publisher: NATURE PUBLISHING GROUP, Pages: 329A-329A, ISSN: 0893-3952
McLean AR, Adlen EK, Cardis E, et al., 2017, A restatement of the natural science evidence base concerning the health effects of low-level ionizing radiation, PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Vol: 284, ISSN: 0962-8452
Saenko VA, Thomas GA, Yamashita S, 2017, Meeting report: the 5th International expert symposium in Fukushima on radiation and health, ENVIRONMENTAL HEALTH, Vol: 16, ISSN: 1476-069X
Cardoso F, van't Veer LJ, Bogaerts J, et al., 2016, 70-Gene Signature as an Aid to Treatment Decisions in Early-Stage Breast Cancer, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 375, Pages: 717-729, ISSN: 0028-4793
Handkiewicz-Junak D, Swierniak M, Rusinek D, et al., 2016, Gene signature of the post-Chernobyl papillary thyroid cancer, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol: 43, Pages: 1267-1277, ISSN: 1619-7070
Mathieson W, Betsou F, Myshunina T, et al., 2016, The effect of long-term-80 degrees C storage of thyroid biospecimens on RNA quality and ensuring fitness for purpose, JOURNAL OF CLINICAL PATHOLOGY, Vol: 69, Pages: 1105-1108, ISSN: 0021-9746
Mathieson W, Marcon N, Antunes L, et al., 2016, A Critical Evaluation of the PAXgene Tissue Fixation System Morphology, Immunohistochemistry, Molecular Biology, and Proteomics, AMERICAN JOURNAL OF CLINICAL PATHOLOGY, Vol: 146, Pages: 25-40, ISSN: 0002-9173
Thomas GA, Symonds P, 2016, Radiation Exposure and Health Effects - is it Time to Reassess the Real Consequences?, CLINICAL ONCOLOGY, Vol: 28, Pages: 231-236, ISSN: 0936-6555
Wilson C, Gossiel F, Leonard R, et al., 2016, Goserelin, as an ovarian protector during (neo)adjuvant breast cancer chemotherapy, prevents long term altered bone turnover, JOURNAL OF BONE ONCOLOGY, Vol: 5, Pages: 43-49, ISSN: 2212-1366
McArdle I, Fare C, Bearpark M, et al., 2015, Research Data Management 'Green Shoots' Pilot Programme, Final Reports, Research Data Management 'Green Shoots' Pilot Programme, Final Reports
This document contains the final reports of six Research Data Management "Green Shoots" projects run at Imperial College in 2014.
Thomas G, 2015, Don't let fear win, NEW SCIENTIST, Vol: 227, Pages: 26-27, ISSN: 0262-4079
Di Maro G, Salerno P, Unger K, et al., 2014, Anterior gradient protein 2 promotes survival, migration and invasion of papillary thyroid carcinoma cells, Molecular Cancer, Vol: 13, ISSN: 1476-4598
Background: Through a transcriptome microarray analysis, we have isolated Anterior gradient protein 2 (AGR2) as agene up-regulated in papillary thyroid carcinoma (PTC). AGR2 is a disulfide isomerase over-expressed in severalhuman carcinomas and recently linked to endoplasmic reticulum (ER) stress. Here, we analyzed the expression ofAGR2 in PTC and its functional role.Methods: Expression of AGR2 was studied by immunohistochemistry and real time PCR in normal thyroidsand in PTC samples. The function of AGR2 was studied by knockdown in PTC cells and by ectopic expressionin non-transformed thyroid cells. The role of AGR2 in the ER stress was analyzed upon treatment of cells,expressing or not AGR2, with Bortezomib and analyzing by Western blot the expression levels of GADD153.Results: PTC over-expressed AGR2 at mRNA and protein levels. Knockdown of AGR2 in PTC cells inducedapoptosis and decreased migration and invasion. Ectopic expression of AGR2 in non-transformed human thyroid cellsincreased migration and invasion and protected cells from ER stress induced by Bortezomib.Conclusions: AGR2 is a novel marker of PTC and plays a role in thyroid cancer cell survival, migration, invasion andprotection from ER stress.
Kofanova OA, Mathieson W, Thomas GA, et al., 2014, DNA Fingerprinting: A Quality Control Case Study for Human Biospecimen Authentication, BIOPRESERVATION AND BIOBANKING, Vol: 12, Pages: 151-153, ISSN: 1947-5535
Lee WE, Ojovan MI, Thomas GA, 2014, The uk's radioactive waste and waste management programme, Pages: 157-175, ISSN: 1042-1122
Sources of the UKs radioactive wastes including from power production, military programmes, medical uses and research reactors are described along with options for managing controlled wastes from pretreatment, treatment, conditioning and storage stages through to transportation to final disposal. Immobilisation (wasteform), temporary storage and permanent disposal options including near surface, deep and very deep geological disposal are covered.
Likhtarov I, Thomas G, Kovgan L, et al., 2013, Reconstruction of individual thyroid doses to the Ukrainian subjects enrolled in the Chernobyl Tissue Bank, RADIATION PROTECTION DOSIMETRY, Vol: 156, Pages: 407-423, ISSN: 0144-8420
Mathieson W, Thomas GA, 2013, Simultaneously extracting DNA, RNA, and protein using kits: Is sample quantity or quality prejudiced?, ANALYTICAL BIOCHEMISTRY, Vol: 433, Pages: 10-18, ISSN: 0003-2697
Ricarte-Filho JC, Li S, Garcia-Rendueles MER, et al., 2013, Identification of kinase fusion oncogenes in post-Chernobyl radiation-induced thyroid cancers, JOURNAL OF CLINICAL INVESTIGATION, Vol: 123, Pages: 4935-4944, ISSN: 0021-9738
Thomas G, 2013, Keynote address: Overcoming the challenges of biospecimen collection for R&D, clinical trials and biobanking, EUROPEAN JOURNAL OF CANCER, Vol: 49, Pages: S8-S8, ISSN: 0959-8049
Dom G, Tarabichi M, Unger K, et al., 2012, A gene expression signature distinguishes normal tissues of sporadic and radiation-induced papillary thyroid carcinomas, British Journal of Cancer, Vol: 107, Pages: 994-1000, ISSN: 1532-1827
background: Papillary thyroid cancer (PTC) incidence increased dramatically in children after the Chernobyl accident, providing a unique opportunity to investigate the molecular features of radiation-induced thyroid cancer. In contrast to the previous studies that included age-related confounding factors, we investigated mRNA expression in PTC and in the normal contralateral tissues of patients exposed and non-exposed to the Chernobyl fallout, using age- and ethnicity-matched non-irradiated cohorts.methods: Forty-five patients were analysed by full-genome mRNA microarrays. Twenty-two patients have been exposed to the Chernobyl fallout; 23 others were age-matched and resident in the same regions of Ukraine, but were born after 1 March 1987, that is, were not exposed to 131I.results: A gene expression signature of 793 probes corresponding to 403 genes that permitted differentiation between normal tissues from patients exposed and from those who were not exposed to radiation was identified. The differences were confirmed by quantitative RT-PCR. Many deregulated pathways in the exposed normal tissues are related to cell proliferation.conclusion: Our results suggest that a higher proliferation rate in normal thyroid could be related to radiation-induced cancer either as a predisposition or as a consequence of radiation. The signature allows the identification of radiation-induced thyroid cancers.
Heiliger K-J, Hess J, Vitagliano D, et al., 2012, Novel candidate genes of thyroid tumourigenesis identified in Trk-T1 transgenic mice, ENDOCRINE-RELATED CANCER, Vol: 19, Pages: 409-421, ISSN: 1351-0088
Hess J, Unger K, Braselmann H, et al., 2012, Gain of chromosome band 7q11 in papillary thyroid carcinomas of young patients is associated with exposure to low-dose irradiation, Joint Meeting of the European Workshop on Cytogenetics and Molecular Genetics of Solid Tumours/Conference of the International-Society-for-Cellular-Oncology (ISCO), Publisher: SPRINGER, Pages: S37-S37, ISSN: 2211-3428
Leonard RCF, Adamson D, Bertelli G, et al., 2012, The relative value of anti-Mullerian hormone to predict premature menopause in patients receiving adjuvant chemotherapy for breast cancer: Results from the OPTION trial, 48th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Publisher: AMER SOC CLINICAL ONCOLOGY, ISSN: 0732-183X
Thomas G, Unger K, Krznaric M, et al., 2012, The Chernobyl Tissue Bank - A Repository for Biomaterial and Data Used in Integrative and Systems Biology Modeling the Human Response to Radiation, GENES, Vol: 3, Pages: 278-290, ISSN: 2073-4425
Thomas GA, 2012, The Chernobyl Tissue Bank: integrating research on radiation-induced thyroid cancer, JOURNAL OF RADIOLOGICAL PROTECTION, Vol: 32, Pages: N77-N80, ISSN: 0952-4746
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