Imperial College London
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ProfessorGrahamWilliams

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Clinical Professor of Endocrinology
 
 
 
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Contact

 

+44 (0)20 3313 1383graham.williams

 
 
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Location

 

10N5Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bassett:2016:10.1210/er.2015-1106,
author = {Bassett, JH and Williams, GR},
doi = {10.1210/er.2015-1106},
journal = {Endocrine Reviews},
title = {Role of thyroid hormones in skeletal development and bone maintenance.},
url = {http://dx.doi.org/10.1210/er.2015-1106},
volume = {37},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The skeleton is an exquisitely sensitive and archetypal T3-target tissue that demonstrates the critical role for thyroid hormones during development, linear growth, and adult bone turnover and maintenance. Thyrotoxicosis is an established cause of secondary osteoporosis, and abnormal thyroid hormone signaling has recently been identified as a novel risk factor for osteoarthritis. Skeletal phenotypes in genetically modified mice have faithfully reproduced genetic disorders in humans, revealing the complex physiological relationship between centrally regulated thyroid status and the peripheral actions of thyroid hormones. Studies in mutant mice also established the paradigm that T3 exerts anabolic actions during growth and catabolic effects on adult bone. Thus, the skeleton represents an ideal physiological system in which to characterize thyroid hormone transport, metabolism, and action during development, adulthood and in response to injury. Future analysis of T3 action in individual skeletal cell lineages will provide new insights into cell-specific molecular mechanisms and may ultimately identify novel therapeutic targets for chronic degenerative diseases such as osteoporosis and osteoarthritis. This review provides a comprehensive analysis of the current state-of-the-art.
AU  - Bassett,JH
AU  - Williams,GR
DO  - 10.1210/er.2015-1106
PY  - 2016///
SN  - 1945-7189
TI  - Role of thyroid hormones in skeletal development and bone maintenance.
T2  - Endocrine Reviews
UR  - http://dx.doi.org/10.1210/er.2015-1106
UR  - http://hdl.handle.net/10044/1/29754
VL  - 37
ER  -
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