Imperial College London
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ProfessorGrahamWilliams

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Clinical Professor of Endocrinology
 
 
 
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Contact

 

+44 (0)20 3313 1383graham.williams

 
 
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Location

 

10N5Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Williams:2017:10.1007/s40618-017-0753-4,
author = {Williams, GR and Bassett, JHD},
doi = {10.1007/s40618-017-0753-4},
journal = {Journal of Endocrinological Investigation},
pages = {99--109},
title = {Thyroid diseases and bone health.},
url = {http://dx.doi.org/10.1007/s40618-017-0753-4},
volume = {41},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Thyroid hormones are essential for skeletal development and are important regulators of bone maintenance in adults. Childhood hypothyroidism causes delayed skeletal development, retarded linear growth and impaired bone mineral accrual. Epiphyseal dysgenesis is evidenced by classic features of stippled epiphyses on X-ray. In severe cases, post-natal growth arrest results in a complex skeletal dysplasia. Thyroid hormone replacement stimulates catch-up growth and bone maturation, but recovery may be incomplete dependent on the duration and severity of hypothyroidism prior to treatment. A severe phenotype characteristic of hypothyroidism occurs in children with resistance to thyroid hormone due to mutations affecting THRA encoding thyroid hormone receptor α (TRα). Discovery of this rare condition recapitulated animal studies demonstrating that TRα mediates thyroid hormone action in the skeleton. In adults, thyrotoxicosis is well known to cause severe osteoporosis and fracture, but cases are rare because of prompt diagnosis and treatment. Recent data, however, indicate that subclinical hyperthyroidism is associated with low bone mineral density (BMD) and an increased risk of fracture. Population studies have also shown that variation in thyroid status within the reference range in post-menopausal women is associated with altered BMD and fracture risk. Thus, thyroid status at the upper end of the euthyroid reference range is associated with low BMD and increased risk of osteoporotic fragility fracture. Overall, extensive data demonstrate that euthyroid status is required for normal post-natal growth and bone mineral accrual, and is fundamental for maintenance of adult bone structure and strength.
AU  - Williams,GR
AU  - Bassett,JHD
DO  - 10.1007/s40618-017-0753-4
EP  - 109
PY  - 2017///
SN  - 0391-4097
SP  - 99
TI  - Thyroid diseases and bone health.
T2  - Journal of Endocrinological Investigation
UR  - http://dx.doi.org/10.1007/s40618-017-0753-4
UR  - http://hdl.handle.net/10044/1/52723
VL  - 41
ER  -
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