Imperial College London

DrGregoryScott

Faculty of MedicineDepartment of Brain Sciences

Academic Clinical Lecturer
 
 
 
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Contact

 

gregory.scott99

 
 
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Location

 

C3NL, Burlington DanesBurlington DanesHammersmith Campus

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Summary

 

Summary

I am a National Institute for Health Research (NIHR) funded Neurology Academic Clinical Lecturer (ACL) and Neurology Registrar.

My research is motivated by clinically important questions about consciousness, its relationship to brain injury and complexity, and how states of consciousness can be practicably measured and manipulated. Clinically this is important because we do not currently have robust accurate measures of brain state that can be used at the bedside, for example to measure the level of consciousness or to easily detect seizure activity.

I have a PhD (GSK-Wellcome Trust funded) from Imperial College London. I also have an MBBS (Medicine), MSc (Advanced Computing) and BEng (Computing), all from Imperial. I enjoy working at the interface of neurology, computational neuroscience and engineering.

In my research I have used a range of tools including functional MRI, diffusion tensor imaging, positron emission tomography, electroencephalography, computational simulations and voltage indicator imaging.   

I have used voltage imaging data in mice (here) to demonstrate how signatures of criticality - a special dynamical regime on the border between order and disorder - emerge in the cortex of mice recovering from anaesthesia. We also showed that critical cortical dynamics are associated with optimisation of information processing capabilities like information capacity and sharing (here). 

In my PhD (https://bit.ly/2sjcuYF), I used multi-modal techniques to characterise the relationship between brain inflammation and white matter damage in patients following moderate-severe traumatic brain injury. I studied the action of the antibiotic minocycline on chronic neuroinflammation.

With Dr Robin Carhart-Harris, I have recently proposed the use of psychedelics as a possible treatment for patients with the most profound impairments of consciousness (https://bit.ly/2VTnObr).

If you're interested in my research or possible collaboration, please get in touch by email. Please note that I cannot give specific clinical advice. 



Selected Publications

Journal Articles

Jolly AE, Raymont V, Cole JH, et al., 2019, Dopamine D2/D3 receptor abnormalities after traumatic brain injury and their relationship to post-traumatic depression, Neuroimage: Clinical, Vol:24, ISSN:2213-1582

Jenkins PO, De Simoni S, Bourke N, et al., 2018, Dopaminergic abnormalities following traumatic brain injury, Brain, Vol:141, ISSN:1460-2156, Pages:797-810

Datta G, Colasanti A, Kalk N, et al., 2017, [(11)C]PBR28 or [(18)F]PBR111 detect white matter inflammatory heterogeneity in multiple sclerosis, Journal of Nuclear Medicine, Vol:58, ISSN:1535-5667, Pages:1477-1482

Feeney C, Sharp DJ, Hellyer PJ, et al., 2017, Serum IGF-I levels are associated with improved white matter recovery after TBI., Annals of Neurology, Vol:82, ISSN:0364-5134, Pages:30-43

Donat CK, Scott G, Gentleman S, et al., 2017, Microglial activation in traumatic brain injury, Frontiers in Aging Neuroscience, Vol:9, ISSN:1663-4365

Datta G, Violante IR, Scott G, et al., 2016, Translocator positron-emission tomography and magnetic resonance spectroscopic imaging of brain glial cell activation in multiple sclerosis., Multiple Sclerosis Journal, Vol:23, ISSN:1352-4585, Pages:1469-1478

De Simoni S, Grover PJ, Jenkins PO, et al., 2016, Disconnection between the default mode network and medial temporal lobes in post-traumatic amnesia, Brain, Vol:139, ISSN:0006-8950, Pages:3137-3150

Feeney C, Scott G, Raffel J, et al., 2016, Kinetic analysis of the translocator protein positron emission tomography ligand [18F]GE-180 in the human brain, European Journal of Nuclear Medicine and Molecular Imaging, Vol:43, ISSN:1619-7089, Pages:2201-2210

Jamall O, Feeney C, Zaw-Linn J, et al., 2016, Prevalence and correlates of vitamin D deficiency in adults after traumatic brain injury, Clinical Endocrinology, Vol:85, ISSN:1365-2265, Pages:636-644

Li LM, Leech R, Scott GT, et al., 2015, The effect of oppositional parietal transcranial direct current stimulation on lateralized brain functions, European Journal of Neuroscience, Vol:42, ISSN:1460-9568, Pages:2904-2914

Fagerholm ED, Hellyer PJ, Scott G, et al., 2015, Disconnection of network hubs and cognitive impairment after traumatic brain injury., Brain, Vol:138, ISSN:0006-8950, Pages:1696-1709

Vijayan R, Scott G, Ahmed F, 2015, What is it about the number of stitches?, British Medical Journal, Vol:350, ISSN:0959-8146

Tillmann T, Gibson AR, Scott G, et al., 2015, Systems Medicine 2.0: Potential Benefits of Combining Electronic Health Care Records With Systems Science Models, Journal of Medical Internet Research, Vol:17, ISSN:1438-8871

Vijayan R, Scott G, Brownlie W, et al., 2015, How Sharp is a "Sharp Scratch"? A Mixed Methods Study of Verbal Warnings Issued Before Venipuncture, Pain Practice, Vol:15, ISSN:1530-7085, Pages:132-139

MacFarlane JW, Payton OD, Keatley AC, et al., 2014, Lightweight aerial vehicles for monitoring, assessment and mapping of radiation anomalies, Journal of Environmental Radioactivity, Vol:136, ISSN:0265-931X, Pages:127-130

Scott G, Sharp DJ, Ramlackhansingh A, et al., 2014, NEUROINFLAMMATION AND AMYLOID PATHOLOGY AFTER TBI, Journal of Neurology Neurosurgery and Psychiatry, Vol:85, ISSN:0022-3050

Jilka SR, Scott G, Ham T, et al., 2014, Damage to the Salience Network and Interactions with the Default Mode Network, Journal of Neuroscience, Vol:34, ISSN:0270-6474, Pages:10798-10807

Leech R, Scott G, Carhart-Harris R, et al., 2014, Spatial Dependencies between Large-Scale Brain Networks, Plos One, Vol:9

Vijayan R, Scott G, Brownlie W, 2014, Out of sight, but not out of mind? Greater reported pain in patients who spontaneously look away during venepuncture, European Journal of Pain, ISSN:1532-2149, Pages:n/a-n/a

Hellyer PJ, Shanahan MP, Scott G, et al., 2014, The control of global brain dynamics: Opposing actions of frontoparietal control and default mode networks on attention, Journal of Neuroscience, Vol:34, ISSN:1529-2401, Pages:451-461

Cramer H, Vijayan R, Scott G, et al., 2014, Out of sight, but not out of mind? Greater reported pain in patients who spontaneously look away during venepuncture, Deutsche Zeitschrift Fur Akupunktur, Vol:57, ISSN:0415-6412, Pages:32-33

Scott G, Presswood EJ, Makubate B, et al., 2013, Lung sounds: how doctors draw crackles and wheeze, Postgraduate Medical Journal, Vol:89, ISSN:0032-5473, Pages:693-697

Vijayan R, Scott G, 2013, Doctor, interrupted, British Medical Journal, Vol:346, ISSN:0007-1447

Vijayan R, Scott G, 2013, An approach to the obstructive colleague, British Medical Journal, Vol:347, ISSN:0007-1447

Scott G, Presswood E, 2012, Case report of E.T.--the extra-terrestrial., Bmj, Vol:345

Scott G, Presswood E, 2012, CHRISTMAS 2012: TOMORROW'S WORLD Case report of E.T.-The Extra-Terrestrial, British Medical Journal, Vol:345, ISSN:1756-1833

Scott G, Vijayan R, Male P, 2011, CHRISTMAS 2011: PROFESSIONAL MATTERS Relevance of the expression "obs stable" in nursing observations: retrospective study, British Medical Journal, Vol:343, ISSN:0959-535X

Scott GPT, Shah P, Wyatt JC, et al., 2011, Making electronic prescribing alerts more effective: scenario-based experimental study in junior doctors, Journal of the American Medical Informatics Association, Vol:18, ISSN:1067-5027, Pages:789-798

Scott G, Cross F, 2010, Reducing insulin errors Try electronic prescribing, British Medical Journal, Vol:341, ISSN:1756-1833

Scott G, Cross F, 2010, Reducing insulin errors. Try electronic prescribing., Bmj, Vol:341

Kavagiou Z, Bello F, Scott G, et al., 2005, Facial Plastic Surgery Planning Using a 3D Surface Deformation Tool, Medicine Meets Virtual Reality 13: the Magical Next Becomes the Medical Now, Vol:111, ISSN:0926-9630, Pages:247-250

Kavagiou Z, Bello F, Scott G, et al., 2005, Facial plastic surgery planning using a 3D surface deformation tool, Stud Health Technol Inform, Vol:111, ISSN:0926-9630, Pages:247-250

Conference

Peress L, Violante IR, Scott G, et al., 2016, Thalamic magnetic resonance spectroscopy in highly active multiple sclerosis, 32nd Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS), SAGE PUBLICATIONS LTD, Pages:210-211, ISSN:1352-4585

Hellyer PJ, Shanahan MP, Scott G, et al., 2012, Global network dynamics during task based activity in the brain., Organisation for Human Brain Mapping

Hellyer PJ, Shanahan MP, Scott G, et al., 2012, Global network dynamics during task based activity in the brain., British Association of Cognitive Neuroscience

Scott G, Hellyer PJ, Shanahan M, et al., 2011, From structural networks to functional networks via coupled oscillators, Neuroscience 2011

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