Imperial College London

DrGregoryScott

Faculty of MedicineDepartment of Medicine

Academic Clinical Lecturer
 
 
 
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Contact

 

gregory.scott99

 
 
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Location

 

C3NL, Burlington DanesBurlington DanesHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

51 results found

Scott G, Carhart-Harris R, Psychedelics as a treatment for disorders of consciousness, Neuroscience of Consciousness, ISSN: 2057-2107

JOURNAL ARTICLE

Cole JH, Jolly A, de Simoni S, Bourke N, Patel MC, Scott G, Sharp DJet al., 2018, Spatial patterns of progressive brain volume loss after moderate-severe traumatic brain injury, BRAIN, Vol: 141, Pages: 822-836, ISSN: 0006-8950

JOURNAL ARTICLE

Jenkins PO, De Simoni S, Bourke NJ, Fleminger J, Scott G, Towey DJ, Svensson W, Khan S, Patel M, Greenwood R, Cole JH, Sharp DJet al., 2018, Dopaminergic abnormalities following traumatic brain injury, BRAIN, Vol: 141, Pages: 797-810, ISSN: 0006-8950

JOURNAL ARTICLE

Scott G, Zetterberg H, Jolly A, Cole JH, De Simoni S, Jenkins PO, Feeney C, Owen DR, Lingford-Hughes A, Howes O, Patel MC, Goldstone AP, Gunn RN, Blennow K, Matthews PM, Sharp DJet al., 2018, Minocycline reduces chronic microglial activation after brain trauma but increases neurodegeneration, BRAIN, Vol: 141, Pages: 459-471, ISSN: 0006-8950

JOURNAL ARTICLE

Datta G, Violante IR, Scott G, Zimmerman K, Santos-Ribeiro A, Rabiner EA, Gunn RN, Malik O, Ciccarelli O, Nicholas R, Matthews PMet al., 2017, Translocator positron-emission tomography and magnetic resonance spectroscopic imaging of brain glial cell activation in multiple sclerosis, MULTIPLE SCLEROSIS JOURNAL, Vol: 23, Pages: 1469-1478, ISSN: 1352-4585

JOURNAL ARTICLE

Datta G, Colasanti A, Kalk N, Owen D, Scott G, Rabiner EA, Gunn RN, Lingford-Hughes A, Malik O, Ciccarelli O, Nicholas R, Nei L, Battaglini M, Stefano ND, Matthews PMet al., 2017, C-11-PBR28 and F-18-PBR111 Detect White Matter Inflammatory Heterogeneity in Multiple Sclerosis, JOURNAL OF NUCLEAR MEDICINE, Vol: 58, Pages: 1477-1482, ISSN: 0161-5505

JOURNAL ARTICLE

Feeney C, Sharp DJ, Hellyer PJ, Jolly AE, Cole JH, Scott G, Baxter D, Jilka S, Ross E, Ham TE, Jenkins PO, Li LM, Gorgoraptis N, Midwinter M, Goldstone APet al., 2017, Serum Insulin-like Growth Factor-I Levels are Associated with Improved White Matter Recovery after Traumatic Brain Injury, ANNALS OF NEUROLOGY, Vol: 82, Pages: 30-43, ISSN: 0364-5134

JOURNAL ARTICLE

Donat CK, Scott G, Gentleman SM, Sastre Met al., 2017, Microglial Activation in Traumatic Brain Injury, FRONTIERS IN AGING NEUROSCIENCE, Vol: 9, ISSN: 1663-4365

JOURNAL ARTICLE

Matthews PM, Datta G, Colasanti A, KALK N, Owen D, Scott G, Rabiner E, Gunn R, Lingford-Hughes A, Malik O, Ciccarelli O, Nicholas R, Nei L, Battaglini M, Stefano Net al., [(11)C]PBR28 or [(18)F]PBR111 detect white matter inflammatory heterogeneity in multiple sclerosis., Journal of Nuclear Medicine, ISSN: 1535-5667

JOURNAL ARTICLE

Scott G, Mahmud M, Owen DR, Johnson MRet al., 2017, Microglial positron emission tomography (PET) imaging in epilepsy: Applications, opportunities and pitfalls, SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, Vol: 44, Pages: 42-47, ISSN: 1059-1311

JOURNAL ARTICLE

De Simoni S, Grover PJ, Jenkins PO, Honeyfield L, Quest RA, Ross E, Scott G, Wilson MH, Majewska P, Waldman AD, Patel MC, Sharp DJet al., 2016, Disconnection between the default mode network and medial temporal lobes in post-traumatic amnesia, BRAIN, Vol: 139, Pages: 3137-3150, ISSN: 0006-8950

JOURNAL ARTICLE

Feeney C, Scott G, Raffel J, Roberts S, Coello C, Jolly A, Searle G, Goldstone AP, Brooks DJ, Nicholas RS, Trigg W, Gunn RN, Sharp DJet al., 2016, Kinetic analysis of the translocator protein positron emission tomography ligand [F-18]GE-180 in the human brain, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol: 43, Pages: 2201-2210, ISSN: 1619-7070

JOURNAL ARTICLE

Jamall OA, Feeney C, Zaw-Linn J, Malik A, Niemi MEK, Tenorio-Jimenez C, Ham TE, Jilka SR, Jenkins PO, Scott G, Li LM, Gorgoraptis N, Baxter D, Sharp DJ, Goldstone APet al., 2016, Prevalence and correlates of vitamin D deficiency in adults after traumatic brain injury, CLINICAL ENDOCRINOLOGY, Vol: 85, Pages: 636-644, ISSN: 0300-0664

JOURNAL ARTICLE

Fagerholm ED, Scott G, Shew WL, Song C, Leech R, Knopfel T, Sharp DJet al., 2016, Cortical Entropy, Mutual Information and Scale-Free Dynamics in Waking Mice, CEREBRAL CORTEX, Vol: 26, Pages: 3945-3952, ISSN: 1047-3211

JOURNAL ARTICLE

Peress L, Violante IR, Scott G, Zimmerman K, Sharp D, Nicholas R, Raffel Jet al., 2016, Thalamic magnetic resonance spectroscopy in highly active multiple sclerosis, 32nd Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS), Publisher: SAGE PUBLICATIONS LTD, Pages: 210-211, ISSN: 1352-4585

CONFERENCE PAPER

Feeney C, Scott GP, Cole JH, Sastre M, Goldstone AP, Leech Ret al., 2016, Seeds of neuroendocrine doubt, NATURE, Vol: 535, Pages: E1-E2, ISSN: 0028-0836

JOURNAL ARTICLE

Dinov M, Lorenz R, Scott G, Sharp DJ, Fagerholmand ED, Leech Ret al., 2016, Novel Modeling of Task vs. Rest Brain State Predictability Using a Dynamic Time Warping Spectrum: Comparisons and Contrasts with Other Standard Measures of Brain Dynamics, FRONTIERS IN COMPUTATIONAL NEUROSCIENCE, Vol: 10, ISSN: 1662-5188

JOURNAL ARTICLE

Scott G, Ramlackhansingh AF, Edison P, Hellyer P, Cole J, Veronese M, Leech R, Greenwood RJ, Turkheimer FE, Gentleman SM, Heckemann RA, Matthews PM, Brooks DJ, Sharp DJet al., 2016, Amyloid pathology and axonal injury after brain trauma, NEUROLOGY, Vol: 86, Pages: 821-828, ISSN: 0028-3878

JOURNAL ARTICLE

Zimmerman K, Scott G, Violante I, Feeney C, Sharp Det al., 2016, Magnetic resonance spectroscopy of the thalamus in chronic traumatic brain injury, Publisher: TAYLOR & FRANCIS INC, Pages: 660-661, ISSN: 0269-9052

CONFERENCE PAPER

Scott G, Gunn RN, Matthews PM, Sharp DJet al., 2016, Minocycline reduces microglial activation after traumatic brain injury measured using [11C]-PBR28 positron emission tomography, Publisher: TAYLOR & FRANCIS INC, Pages: 686-687, ISSN: 0269-9052

CONFERENCE PAPER

Scott G, Hellyer PJ, Ramlackhansingh AF, Brooks DJ, Matthews PM, Sharp DJet al., 2015, Thalamic inflammation after brain trauma is associated with thalamo-cortical white matter damage, JOURNAL OF NEUROINFLAMMATION, Vol: 12, ISSN: 1742-2094

JOURNAL ARTICLE

Li LM, Leech R, Scott G, Malhotra P, Seemungal B, Sharp DJet al., 2015, The effect of oppositional parietal transcranial direct current stimulation on lateralized brain functions, EUROPEAN JOURNAL OF NEUROSCIENCE, Vol: 42, Pages: 2904-2914, ISSN: 0953-816X

JOURNAL ARTICLE

Vasa F, Shanahan M, Hellyer PJ, Scott G, Cabral J, Leech Ret al., 2015, Effects of lesions on synchrony and metastability in cortical networks, NEUROIMAGE, Vol: 118, Pages: 456-467, ISSN: 1053-8119

JOURNAL ARTICLE

Hellyer PJ, Scott G, Shanahan M, Sharp DJ, Leech Ret al., 2015, Cognitive Flexibility through Metastable Neural Dynamics Is Disrupted by Damage to the Structural Connectome, JOURNAL OF NEUROSCIENCE, Vol: 35, Pages: 9050-9063, ISSN: 0270-6474

JOURNAL ARTICLE

Fagerholm ED, Hellyer PJ, Scott G, Leech R, Sharp DJet al., 2015, Disconnection of network hubs and cognitive impairment after traumatic brain injury, BRAIN, Vol: 138, Pages: 1696-1709, ISSN: 0006-8950

JOURNAL ARTICLE

Scott G, Hellyer PJ, Hampshire A, Leech Ret al., 2015, Exploring Spatiotemporal Network Transitions in Task Functional MRI, HUMAN BRAIN MAPPING, Vol: 36, Pages: 1348-1364, ISSN: 1065-9471

JOURNAL ARTICLE

Tillmann T, Gibson AR, Scott G, Harrison O, Dominiczak A, Hanlon Pet al., 2015, Systems Medicine 2.0: potential benefits of combining electronic health care records with systems science models., J Med Internet Res, Vol: 17

BACKGROUND: The global burden of disease is increasingly dominated by non-communicable diseases.These diseases are less amenable to curative and preventative interventions than communicable disease. This presents a challenge to medical practice and medical research, both of which are experiencing diminishing returns from increasing investment. OBJECTIVE: Our aim was to (1) review how medical knowledge is generated, and its limitations, (2) assess the potential for emerging technologies and ideas to improve medical research, and (3) suggest solutions and recommendations to increase medical research efficiency on non-communicable diseases. METHODS: We undertook an unsystematic review of peer-reviewed literature and technology websites. RESULTS: Our review generated the following conclusions and recommendations. (1) Medical knowledge continues to be generated in a reductionist paradigm. This oversimplifies our models of disease, rendering them ineffective to sufficiently understand the complex nature of non-communicable diseases. (2) Some of these failings may be overcome by adopting a "Systems Medicine" paradigm, where the human body is modeled as a complex adaptive system. That is, a system with multiple components and levels interacting in complex ways, wherein disease emerges from slow changes to the system set-up. Pursuing systems medicine research will require larger datasets. (3) Increased data sharing between researchers, patients, and clinicians could provide this unmet need for data. The recent emergence of electronic health care records (EHR) could potentially facilitate this in real-time and at a global level. (4) Efforts should continue to aggregate anonymous EHR data into large interoperable data silos and release this to researchers. However, international collaboration, data linkage, and obtaining additional information from patients will remain challenging. (5) Efforts should also continue towards "Medicine 2.0". Patients should be

JOURNAL ARTICLE

Fagerholm ED, Lorenz R, Scott G, Dinov M, Hellyer PJ, Mirzaei N, Leeson C, Carmichael DW, Sharp DJ, Shew WL, Leech Ret al., 2015, Cascades and Cognitive State: Focused Attention Incurs Subcritical Dynamics, JOURNAL OF NEUROSCIENCE, Vol: 35, Pages: 4626-4634, ISSN: 0270-6474

JOURNAL ARTICLE

Vijayan R, Scott G, Ahmed F, 2015, What is it about the number of stitches?, BMJ, Vol: 350, Pages: h1042-h1042

JOURNAL ARTICLE

Vijayan R, Scott G, Brownlie W, Male P, Chin Ket al., 2015, How Sharp is a "Sharp Scratch"? A Mixed Methods Study of Verbal Warnings Issued Before Venipuncture, PAIN PRACTICE, Vol: 15, Pages: 132-139, ISSN: 1530-7085

JOURNAL ARTICLE

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