Hani Gabra is Professor of Medical Oncology at Imperial College London and Honorary Consultant Medical Oncologist at Imperial College Healthcare NHS Trust, based at the Hammersmith Campus of Imperial College.
He holds these appointments part-time concurrently with his position as Chief Physician Scientist and Vice President / Head of the Clinical Discovery Unit in Early Clinical Development within the IMED Biotech Unit at AstraZeneca in Cambridge
Until May 2017 he was Head of the Molecular Therapeutics Unit, Deputy Head of the Division of Cancer and Director of the Ovarian Cancer Action Research Centre at Imperial College, and at Imperial College Healthcare NHS Trust he was also Head of Medical Oncology and Chair of the Cancer Research Committee. Until May 2017 he was also Associate Director and Lead of the Cancer Division (Division 1) of the NIHR Clinical Research Network for North West London.
Hani studied Medicine at the University of Glasgow and graduated with a BSc (Hons) in Molecular Biology and MB ChB in 1987. After obtaining MRCP(UK) in 1990, he undertook an MSc in Clinical Oncology and a PhD in Molecular Oncology from the University of Edinburgh. He then completed his specialist training in Cancer Medicine in Edinburgh and was CRUK Clinical Scientist and Consultant Medical Oncologist at the CRUK Edinburgh Medical Oncology Unit from 1998-2003, following which he took up his Chair appointment at Imperial College.
He is a Fellow of the Royal College of Physicians of Edinburgh and London.
His laboratory is involved in trying to understand the role of tumour suppressor genes in ovarian cancer, particularly how OPCML regulates networks of receptor tyrosine kinases and how WWOX acts to regulate taxane sensitivity.
His clinical / translational interests relate to the understanding of platinum resistance in ovarian cancer, and he has developed several molecular targets whose inhibition can reverse platinum resistance from laboratory to clinic; such targets include AKT, MTOR, HDAC4, STAT1 and the Folate Receptors.
Until September 2017 he was founding President of the European Translational Ovarian Cancer Network (EUTROC), a multinational group that undertakes science in ovarian cancer clinical trials, principally in the context of complex phase II clinical trials.
He previously sat on CRUK CTAAC funding committee for the UK and the INCa Scientific Evaluation Committee, Institut National Du Cancer of France.
et al., Adiposity and cancer at all anatomic sites: an umbrella review of the literature, British Medical Journal, ISSN:1468-5833
et al., 2018, Dynamics of the Intratumoral Immune Response during Progression of High-Grade Serous Ovarian Cancer, Neoplasia, Vol:20, ISSN:1476-5586, Pages:280-288
et al., 2018, Impact of lympho-vascular space invasion on tumor characteristics and survival outcome of women with low-grade serous ovarian carcinoma, Journal of Surgical Oncology, Vol:117, ISSN:0022-4790, Pages:236-244
et al., 2017, WWOX sensitises ovarian cancer cells to paclitaxel via modulation of the ER stress response, Cell Death & Disease, Vol:8, ISSN:2041-4889
et al., 2017, Exploring the clonal evolution of CD133/aldehyde-dehydrogenase-1 (ALDH1)-positive cancer stem-like cells from primary to recurrent high-grade serous ovarian cancer (HGSOC). A study of the Ovarian Cancer Therapy-Innovative Models Prolong Survival (OCTIPS) Consortium, European Journal of Cancer, Vol:79, ISSN:0959-8049, Pages:214-225