Imperial College London
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Dr Harriet Kemp

Faculty of Medicine, Department of Surgery & Cancer

Clinical Lecturer
 
 
 
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Contact

 

h.kemp

 
 
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Location

 

Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kennedy:2016:10.1097/j.pain.0000000000000689,
author = {Kennedy, DL and Kemp, HI and Ridout, D and Yarnitsky, D and Rice, AS},
doi = {10.1097/j.pain.0000000000000689},
journal = {Pain},
pages = {2410--2419},
title = {Reliability of Conditioned Pain Modulation: a Systematic Review},
url = {http://dx.doi.org/10.1097/j.pain.0000000000000689},
volume = {157},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - A systematic literature review was undertaken to determine if conditioned pain modulation (CPM) is reliable. Longitudinal, English language observational studies of the repeatability of a CPM test paradigm in adult humans were included. Two independent reviewers assessed the risk of bias in six domains; study participation; study attrition; prognostic factor measurement; outcome measurement; confounding and analysis using the Quality in Prognosis Studies (QUIPS) critical assessment tool [17]. Intraclass correlation coefficients (ICCs) less than 0.4 were considered to be poor; 0.4 and 0.59 to be fair; 0.6 and 0.75 good and greater than 0.75 excellent [37]. Ten studies were included in the final review. Meta-analysis was not appropriate due to differences between studies. The intersession reliability of the CPM effect was investigated in 8 studies and reported as good (ICC = 0.6-.75) in 3 studies and excellent (ICC > .75) in subgroups in 2 of those 3. The assessment of risk of bias demonstrated that reporting is not comprehensive for the description of sample demographics, recruitment strategy and study attrition. The absence of blinding, a lack of control for confounding factors and lack of standardisation in statistical analysis are common. CPM is a reliable measure, however the degree of reliability is heavily dependent upon stimulation parameters and study methodology and this warrants consideration for investigators. The validation of CPM as a robust prognostic factor in experimental and clinical pain studies may be facilitated by improvements in the reporting of CPM reliability studies.
AU  - Kennedy,DL
AU  - Kemp,HI
AU  - Ridout,D
AU  - Yarnitsky,D
AU  - Rice,AS
DO  - 10.1097/j.pain.0000000000000689
EP  - 2419
PY  - 2016///
SN  - 1872-6623
SP  - 2410
TI  - Reliability of Conditioned Pain Modulation: a Systematic Review
T2  - Pain
UR  - http://dx.doi.org/10.1097/j.pain.0000000000000689
UR  - http://hdl.handle.net/10044/1/42078
VL  - 157
ER  -
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