Imperial College London
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Dr Harriet Kemp

Faculty of Medicine, Department of Surgery & Cancer

Clinical Lecturer
 
 
 
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Contact

 

h.kemp

 
 
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Location

 

Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kemp:2017:10.1001/jamaophthalmol.2017.1703,
author = {Kemp, HI and Petropoulos, IN and Rice, ASC and Vollert, J and Maier, C and Strum, D and Schargus, M and Peto, T and Hau, S and Chopra, R and Malik, RA},
doi = {10.1001/jamaophthalmol.2017.1703},
journal = {JAMA Ophthalmology},
pages = {795--800},
title = {Use of corneal confocal microscopy to evaluate small nerve fibers in patients with human immunodeficiency virus},
url = {http://dx.doi.org/10.1001/jamaophthalmol.2017.1703},
volume = {135},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Importance  Objective quantification of small fiber neuropathy in patients with human immunodeficiency virus (HIV)–associated sensory neuropathy (HIV-SN) is difficult but needed for diagnosis and monitoring. In vivo corneal confocal microscopy (IVCCM) can quantify small fiber damage.Objective  To establish whether IVCCM can identify an abnormality in corneal nerve fibers and Langerhans cells in patients with and without HIV-SN.Design, Setting, and Participants  This prospective, cross-sectional cohort study was conducted between July 24, 2015, and September 17, 2015. Twenty patients who were HIV positive were recruited from adult outpatient clinics at Chelsea and Westminster Hospital NHS Foundation Trust in England. These patients underwent IVCCM at Moorfields Eye Hospital NHS Foundation Trust in London, England, and the IVCCM images were analyzed at Weill Cornell Medicine–Qatar in Ar-Rayyan, Qatar. Patients were given a structured clinical examination and completed validated symptom questionnaires and the Clinical HIV-Associated Neuropathy Tool. Results from patients with HIV were compared with the results of the age- and sex-matched healthy control participants (n = 20). All participants were classified into 3 groups: controls, patients with HIV but without SN, and patients with HIV-SN.Main Outcomes and Measures  Comparison of corneal nerve fiber density, corneal nerve branch density, corneal nerve fiber length, corneal nerve fiber tortuosity, and corneal Langerhans cell density between healthy controls and patients with HIV with and without SN.Results  All 40 participants were male, and most (≥70%) self-identified as white. Of the 20 patients with HIV, 14 (70%) had HIV-SN. This group was older (mean [SD] age, 57.7 [7.75] years) than the group without HIV-SN (mean [SD] age, 42.3 [7.26] years) and the controls (mean [SD] age, 53.8 [10.5] years). Corneal nerve fiber density was reduced in patients with HIV compared with the controls (26.
AU  - Kemp,HI
AU  - Petropoulos,IN
AU  - Rice,ASC
AU  - Vollert,J
AU  - Maier,C
AU  - Strum,D
AU  - Schargus,M
AU  - Peto,T
AU  - Hau,S
AU  - Chopra,R
AU  - Malik,RA
DO  - 10.1001/jamaophthalmol.2017.1703
EP  - 800
PY  - 2017///
SN  - 2168-6173
SP  - 795
TI  - Use of corneal confocal microscopy to evaluate small nerve fibers in patients with human immunodeficiency virus
T2  - JAMA Ophthalmology
UR  - http://dx.doi.org/10.1001/jamaophthalmol.2017.1703
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000405531700026&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://jamanetwork.com/journals/jamaophthalmology/fullarticle/2630812
UR  - http://hdl.handle.net/10044/1/51389
VL  - 135
ER  -
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