Imperial College London
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Dr Harriet Kemp

Faculty of Medicine, Department of Surgery & Cancer

Clinical Lecturer
 
 
 
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Contact

 

h.kemp

 
 
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Location

 

Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Citation

BibTex format

@article{Rice:2018:10.1097/j.pain.0000000000001138,
author = {Rice, ASC and Finnerup, NB and Kemp, HI and Currie, GL and Baron, R},
doi = {10.1097/j.pain.0000000000001138},
journal = {PAIN},
pages = {819--824},
title = {Sensory profiling in animal models of neuropathic pain: a call for back-translation.},
url = {http://dx.doi.org/10.1097/j.pain.0000000000001138},
volume = {159},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - This Topical review considers the misalignment between outcome measures traditionally reported in animal models of neuropathic pain (For brevity, we will adhere to convention and use the shorthand “animal model of neuropathic pain.” However, we suggest that a more accurate classification is in terms of the disease they purportedly mimic [eg, traumatic nerve injury, diabetic neuropathy, etc] rather than as a model of “pain.”) and those used for estimating pain intensity and the impact/burden of pain in clinical trials. In particular, we propose that traditional methods of assessing rodent sensory thresholds could have predictive utility for the sensory profiling approaches being explored for patient stratification in clinical trials. To initiate this process, we propose a “research agenda” to develop and validate a protocol and normative values for sensory profiling in rodents, which reflects the best established clinical methods. This could then be used to establish definitive sensory profiles of new and existing rodent neuropathic pain models.In general, animal modelling of neuropathic pain has 2 main goals: First, to identify pain mechanisms and thus potential targets for drug development. However, it is difficult to identify clear examples of the success of this approach in delivering new drugs for neuropathic pain, with the exception of high concentration topical capsaicin.22 Second, animal models are used in an attempt to predict the clinical efficacy of a novel therapeutic and thus justify the initiation of clinical trials. We concentrate on the latter aspect and ask whether the drug response associated with specific sensory profiles in animal models might predict the most appropriate patients to examine in exploratory clinical trials?
AU  - Rice,ASC
AU  - Finnerup,NB
AU  - Kemp,HI
AU  - Currie,GL
AU  - Baron,R
DO  - 10.1097/j.pain.0000000000001138
EP  - 824
PY  - 2018///
SN  - 0304-3959
SP  - 819
TI  - Sensory profiling in animal models of neuropathic pain: a call for back-translation.
T2  - PAIN
UR  - http://dx.doi.org/10.1097/j.pain.0000000000001138
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29300280
UR  - http://hdl.handle.net/10044/1/60905
VL  - 159
ER  -
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