Imperial College London
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ProfessorHectorKeun

Faculty of Medicine, Department of Surgery & Cancer

Professor of Biochemistry
 
 
 
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Contact

 

+44 (0)20 7594 3161h.keun

 
 
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Location

 

officesInstitute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Chadeau-Hyam:2014:annonc/mdu056,
author = {Chadeau-Hyam, M and Vermeulen, RCH and Hebels, DGAJ and Castagne, R and Campanella, G and Portengen, L and Kelly, RS and Bergdahl, IA and Melin, B and Hallmans, G and Palli, D and Krogh, V and Tumino, R and Sacerdote, C and Panico, S and de, Kok TMCM and Smith, MT and Kleinjans, JCS and Vineis, P and Kyrtopoulos, SA},
doi = {annonc/mdu056},
journal = {Annals of Oncology},
pages = {1065--1072},
title = {Prediagnostic transcriptomic markers of Chronic lymphocytic leukemia reveal perturbations 10 years before diagnosis},
url = {http://dx.doi.org/10.1093/annonc/mdu056},
volume = {25},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundB-cell lymphomas are a diverse group of hematological neoplasms with differential etiology and clinical trajectories. Increased insights in the etiology and the discovery of prediagnostic markers have the potential to improve the clinical course of these neoplasms.MethodsWe investigated in a prospective study global gene expression in peripheral blood mononuclear cells of 263 incident B-cell lymphoma cases, diagnosed between 1 and 17 years after blood sample collection, and 439 controls, nested within two European cohorts.ResultsOur analyses identified only transcriptomic markers for specific lymphoma subtypes; few markers of multiple myeloma (N = 3), and 745 differentially expressed genes in relation to future risk of chronic lymphocytic leukemia (CLL). The strongest of these associations were consistently found in both cohorts and were related to (B-) cell signaling networks and immune system regulation pathways. CLL markers exhibited very high predictive abilities of disease onset even in cases diagnosed more than 10 years after blood collection.ConclusionsThis is the first investigation on blood cell global gene expression and future risk of B-cell lymphomas. We mainly identified genes in relation to future risk of CLL that are involved in biological pathways, which appear to be mechanistically involved in CLL pathogenesis. Many but not all of the top hits we identified have been reported previously in studies based on tumor tissues, therefore suggesting that a mixture of preclinical and early disease markers can be detected several years before CLL clinical diagnosis.
AU  - Chadeau-Hyam,M
AU  - Vermeulen,RCH
AU  - Hebels,DGAJ
AU  - Castagne,R
AU  - Campanella,G
AU  - Portengen,L
AU  - Kelly,RS
AU  - Bergdahl,IA
AU  - Melin,B
AU  - Hallmans,G
AU  - Palli,D
AU  - Krogh,V
AU  - Tumino,R
AU  - Sacerdote,C
AU  - Panico,S
AU  - de,Kok TMCM
AU  - Smith,MT
AU  - Kleinjans,JCS
AU  - Vineis,P
AU  - Kyrtopoulos,SA
DO  - annonc/mdu056
EP  - 1072
PY  - 2014///
SN  - 0923-7534
SP  - 1065
TI  - Prediagnostic transcriptomic markers of Chronic lymphocytic leukemia reveal perturbations 10 years before diagnosis
T2  - Annals of Oncology
UR  - http://dx.doi.org/10.1093/annonc/mdu056
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000335774200023&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.annalsofoncology.org/article/S0923-7534(19)34778-7/fulltext#secst0015
VL  - 25
ER  -
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