Imperial College London
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ProfessorHectorKeun

Faculty of Medicine, Department of Surgery & Cancer

Professor of Biochemistry
 
 
 
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Contact

 

+44 (0)20 7594 3161h.keun

 
 
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Location

 

officesInstitute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Chan:2014:10.3390/molecules19033460,
author = {Chan, PH and Zhang, WL and Lau, C-H and Cheung, CY and Keun, HC and Tsim, KWK and Lam, H},
doi = {10.3390/molecules19033460},
journal = {Molecules},
pages = {3460--3470},
title = {Metabonomic analysis of water extracts from different angelica roots by H-1-nuclear magnetic resonance spectroscopy},
url = {http://dx.doi.org/10.3390/molecules19033460},
volume = {19},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Angelica Radix, the roots of the genus Angelica, has been used for more than 2,000 years as a traditional medicine in Eastern Asia. The Chinese Pharmacopoeia records more than 100 herbal formulae containing Angelica roots. There are two common sources of Angelica roots, Angelica sinensis from China and A. gigas from Korea. The two species of Angelica roots differ in their chemical compositions, pharmacological properties and clinical efficacy. 1H-NMR metabolic profiling has recently emerged as a promising quality control method for food and herbal chemistry. We explored the use of 1H-NMR metabolic profiling for the quality control of Angelica Radix. Unlike previous work, we performed the metabolic profiling on hot water extracts, so as to mimic the clinically relevant preparation method. Unsupervised principle component analyses of both the full spectral profile and a selection of targeted molecules revealed a clear differentiation of three types of Angelica roots. In addition, the levels of 13 common metabolites were measured. Statistically significant differences in the levels of glucose, fructose and threonine were found between different sources of Angelica. Ferulic acid, a marker commonly used to evaluate Angelica root, was detected in our samples, but the difference in ferulic acid levels between the samples was not statistically significant. Overall, we successfully applied 1H-NMR metabolic profiling with water extraction to discriminate all three sources of Angelica roots, and obtained quantitative information of many common metabolites.
AU  - Chan,PH
AU  - Zhang,WL
AU  - Lau,C-H
AU  - Cheung,CY
AU  - Keun,HC
AU  - Tsim,KWK
AU  - Lam,H
DO  - 10.3390/molecules19033460
EP  - 3470
PY  - 2014///
SN  - 1420-3049
SP  - 3460
TI  - Metabonomic analysis of water extracts from different angelica roots by H-1-nuclear magnetic resonance spectroscopy
T2  - Molecules
UR  - http://dx.doi.org/10.3390/molecules19033460
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000335826800048&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/70163
VL  - 19
ER  -
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