Imperial College London
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ProfessorHectorKeun

Faculty of Medicine, Department of Surgery & Cancer

Professor of Biochemistry
 
 
 
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Contact

 

+44 (0)20 7594 3161h.keun

 
 
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Location

 

officesInstitute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hendrickx:2015:bioinformatics/btu827,
author = {Hendrickx, DM and Aerts, HJWL and Caiment, F and Clark, D and Ebbels, TMD and Evelo, CT and Gmuender, H and Hebels, DGAJ and Herwig, R and Hescheler, J and Jennen, DGJ and Jetten, MJA and Kanterakis, S and Keun, HC and Matser, V and Overington, JP and Pilicheva, E and Sarkans, U and Segura-Lepe, MP and Sotiriadou, I and Wittenberger, T and Wittwehr, C and Zanzi, A and Kleinjans, JCS},
doi = {bioinformatics/btu827},
journal = {Bioinformatics},
pages = {1505--1507},
title = {diXa: a data infrastructure for chemical safety assessment},
url = {http://dx.doi.org/10.1093/bioinformatics/btu827},
volume = {31},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Motivation: The field of toxicogenomics (the application of ‘-omics’ technologies to risk assessment of compound toxicities) has expanded in the last decade, partly driven by new legislation, aimed at reducing animal testing in chemical risk assessment but mainly as a result of a paradigm change in toxicology towards the use and integration of genome wide data. Many research groups worldwide have generated large amounts of such toxicogenomics data. However, there is no centralized repository for archiving and making these data and associated tools for their analysis easily available.Results: The Data Infrastructure for Chemical Safety Assessment (diXa) is a robust and sustainable infrastructure storing toxicogenomics data. A central data warehouse is connected to a portal with links to chemical information and molecular and phenotype data. diXa is publicly available through a user-friendly web interface. New data can be readily deposited into diXa using guidelines and templates available online. Analysis descriptions and tools for interrogating the data are available via the diXa portal.Availability and implementation:http://www.dixa-fp7.euContact:d.hendrickx@maastrichtuniversity.nl; info@dixa-fp7.euSupplementary information:Supplementary data are available at Bioinformatics online.
AU  - Hendrickx,DM
AU  - Aerts,HJWL
AU  - Caiment,F
AU  - Clark,D
AU  - Ebbels,TMD
AU  - Evelo,CT
AU  - Gmuender,H
AU  - Hebels,DGAJ
AU  - Herwig,R
AU  - Hescheler,J
AU  - Jennen,DGJ
AU  - Jetten,MJA
AU  - Kanterakis,S
AU  - Keun,HC
AU  - Matser,V
AU  - Overington,JP
AU  - Pilicheva,E
AU  - Sarkans,U
AU  - Segura-Lepe,MP
AU  - Sotiriadou,I
AU  - Wittenberger,T
AU  - Wittwehr,C
AU  - Zanzi,A
AU  - Kleinjans,JCS
DO  - bioinformatics/btu827
EP  - 1507
PY  - 2015///
SN  - 1367-4803
SP  - 1505
TI  - diXa: a data infrastructure for chemical safety assessment
T2  - Bioinformatics
UR  - http://dx.doi.org/10.1093/bioinformatics/btu827
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000355665800031&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://academic.oup.com/bioinformatics/article/31/9/1505/200092
UR  - http://hdl.handle.net/10044/1/93305
VL  - 31
ER  -
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