Imperial College London
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ProfessorHectorKeun

Faculty of Medicine, Department of Surgery & Cancer

Professor of Biochemistry
 
 
 
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Contact

 

+44 (0)20 7594 3161h.keun

 
 
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Location

 

officesInstitute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Giskeodegard:2015:10.1038/srep14843,
author = {Giskeodegard, GF and Davies, SK and Revell, VL and Keun, H and Skene, DJ},
doi = {10.1038/srep14843},
journal = {Scientific Reports},
title = {Diurnal rhythms in the human urine metabolome during sleep and total sleep deprivation},
url = {http://dx.doi.org/10.1038/srep14843},
volume = {5},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Understanding how metabolite levels change over the 24hour day is of crucial importance forclinical and epidemiological studies. Additionally, the association between sleep deprivation andmetabolic disorders such as diabetes and obesity requires investigation into the links between sleepand metabolism. Here, we characterise time-of-day variation and the effects of sleep deprivationon urinary metabolite profiles. Healthy male participants (n=15) completed an in-laboratory studycomprising one 24h sleep/wake cycle prior to 24h of continual wakefulness under highly controlledenvironmental conditions. Urine samples were collected over set 2–8h intervals and analysed by 1HNMR spectroscopy. Significant changes were observed with respect to both time of day and sleepdeprivation. Of 32 identified metabolites, 7 (22%) exhibited cosine rhythmicity over at least one24h period; 5 exhibiting a cosine rhythm on both days. Eight metabolites significantly increasedduring sleep deprivation compared with sleep (taurine, formate, citrate, 3-indoxyl sulfate, carnitine,3-hydroxyisobutyrate, TMAO and acetate) and 8 significantly decreased (dimethylamine, 4-DTA,creatinine, ascorbate, 2-hydroxyisobutyrate, allantoin, 4-DEA, 4-hydroxyphenylacetate). These dataindicate that sampling time, the presence or absence of sleep and the response to sleep deprivationare highly relevant when identifying biomarkers in urinary metabolic profiling studies.
AU  - Giskeodegard,GF
AU  - Davies,SK
AU  - Revell,VL
AU  - Keun,H
AU  - Skene,DJ
DO  - 10.1038/srep14843
PY  - 2015///
SN  - 2045-2322
TI  - Diurnal rhythms in the human urine metabolome during sleep and total sleep deprivation
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/srep14843
UR  - http://hdl.handle.net/10044/1/27639
VL  - 5
ER  -
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