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BibTex format

@article{Antonopoulos:2021:glycob/cwaa085,
author = {Antonopoulos, A and Broome, S and Sharov, V and Ziegenfuss, C and Easton, RL and Panico, M and Morris, HR and Haslam, S},
doi = {glycob/cwaa085},
journal = {Glycobiology},
pages = {181--187},
title = {Site-specific characterisation of SARS-CoV-2 spike glycoprotein receptor binding domain},
url = {http://dx.doi.org/10.1093/glycob/cwaa085},
volume = {31},
year = {2021}
}

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TY  - JOUR
AB  - The novel coronavirus SARS-CoV-2, the infective agent causing COVID-19, is having a global impact both in terms of human disease as well as socially and economically. Its heavily glycosylated spike glycoprotein is fundamental for the infection process, via its receptor binding domains interaction with the glycoprotein angiotensin converting enzyme 2 on human cell surfaces. We therefore utilized an integrated glycomic and glycoproteomic analytical strategy to characterise both N- and O- glycan site specific glycosylation within the receptor binding domain. We demonstrate the presence of complex type N-glycans with unusual fucosylated LacdiNAc at both sites N331 and N343 and a single site of O-glycosylation on T323.
AU  - Antonopoulos,A
AU  - Broome,S
AU  - Sharov,V
AU  - Ziegenfuss,C
AU  - Easton,RL
AU  - Panico,M
AU  - Morris,HR
AU  - Haslam,S
DO  - glycob/cwaa085
EP  - 187
PY  - 2021///
SN  - 0959-6658
SP  - 181
TI  - Site-specific characterisation of SARS-CoV-2 spike glycoprotein receptor binding domain
T2  - Glycobiology
UR  - http://dx.doi.org/10.1093/glycob/cwaa085
UR  - http://hdl.handle.net/10044/1/82154
VL  - 31
ER  -

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Emeritus Professor Howard R. Morris FRS

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