Imperial College London
Portrait Picture

DrHenockTaddese

Faculty of Medicine, School of Public Health

Principal Teaching Fellow
 
 
 
//

Contact

 

+44 (0)20 7594 9475h.taddese Website

 
 
//

Location

 

167Medical SchoolSt Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Makanjuola:2014:10.1371/journal.pone.0087166,
author = {Makanjuola, T and Taddese, HB and Booth, A},
doi = {10.1371/journal.pone.0087166},
journal = {PLoS ONE},
title = {Factors Associated with Adherence to Treatment with Isoniazid for the Prevention of Tuberculosis amongst People Living with HIV/AIDS: A Systematic Review of Qualitative Data},
url = {http://dx.doi.org/10.1371/journal.pone.0087166},
volume = {9},
year = {2014}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objective: To systematically identify from qualitative data in the published literature the main barriers to adherence toisoniazid preventive therapy (IPT) for tuberculosis (TB) among people living with HIV/AIDS (PLWHA).Methods: We searched ten data sources, including MEDLINE and EMBASE for articles published in peer-reviewed journalsfrom inception through to December 2011 for evidence relevant to IPT for TB in relation to PLWHA. Studies were assessedfor quality using the CASP critical appraisal tool for qualitative studies. Data extracted from studies were then analysedthematically using thematic synthesis.Results: Eight studies, two of which were conducted within the same clinical trial, met the inclusion criteria. In addition tothe influence of personal characteristics, five overarching themes were identified: Individual personal beliefs; HIV treatmentand related issues; Socio-economic factors; Family and other social support factors, and Relationships with health providers.The review confirms current understanding of adherence to treatment as influenced by patients’ understanding of, andbeliefs related to treatment regimens. This is in-turn influenced by broader factors, namely: socio-economic factors such aspoverty and lack of health facilities; the level of support available to patients from family and other networks and the stigmathat emanates from these relationships; and relationships with health providers, which in-turn become a delicate issuegiven the sensitivity of dealing with two chronic diseases of significant morbidity and mortality toll. HIV treatment relatedissues also influence adherence to IPT, whereby challenges related to the acceptance, organisation and administration ofthese two long-term treatment regimens and stigma related to HIV/AIDS, are seen to be major factors.Conclusion: Understanding this complex interplay of factors more clearly is essential for healthcare decision-makers to beable to achieve the level of adherence required to
AU  - Makanjuola,T
AU  - Taddese,HB
AU  - Booth,A
DO  - 10.1371/journal.pone.0087166
PY  - 2014///
SN  - 1932-6203
TI  - Factors Associated with Adherence to Treatment with Isoniazid for the Prevention of Tuberculosis amongst People Living with HIV/AIDS: A Systematic Review of Qualitative Data
T2  - PLoS ONE
UR  - http://dx.doi.org/10.1371/journal.pone.0087166
UR  - http://hdl.handle.net/10044/1/54606
VL  - 9
ER  -
Download