Imperial College London

ProfessorHowardThomas

Faculty of MedicineDepartment of Medicine

Emeritus Professor of Hepatology
 
 
 
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Contact

 

+44 (0)20 3312 6454h.thomas

 
 
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Assistant

 

Ms Dawn Campbell +44 (0)20 3312 6454

 
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Location

 

1049 and 1050Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Summary

CURRICULUM VITAE

DATE OF BIRTH: 31 July 1945

DEGREES AND QUALIFICATIONS

  • B.Sc. Class II, Division I, Honours in Physiology
  • Newcastle Upon Tyne, 1966
  • M.B., B.S. with Honours - Newcastle Upon Tyne, 1969
  • Ph.D in Medicine - Glasgow University, 1974
  • Fellow of the Royal College of Physicians - London, 1983
  • Fellow of the Royal College of Physicians and Surgeons, Glasgow, 1984
  • Fellow of the Royal College of Pathologists - London, 1991
  • Fellow of  Academy of  Medical Science 1999

PAST AND PRESENT SENIOR APPOINTMENTS

  • Wellcome Senior Research Fellow in Clinical Science 1978-1983
  • Reader in Medicine, Royal Free Hospital Medical School, London University, 1983-1984
  • Titular Professor of Medicine, Royal Free Hospital Medical School, London University, 1984-1987
  • Professor and Chairman of Medicine, St Marys Hospital Medical School, London University, 1987-1997
  • Professor of Medicine and Head of Department of Medicine A; Deputy Chairman of Division of Medicine; Imperial College School of Medicine; and Consultant Physician/Hepatologist, St Marys Hospital, London, 1997- 2003
  • Dean (Clinical), Faculty of Medicine, Imperial College, 2001- 2004
  • Professor of Medicine and Head of Section of Hepatology and Gastroenterology; Imperial College School of Medicine; and Consultant Physician/Hepatologist, St Marys Hospital, London, 2003- present.

MEMBER/OFFICER  OF LEARNED SOCIETIES

  • Association of Physicians of Great Britain and Ireland (Member)
  • British Association for the Study of the Liver, President 1996-1998
  • European Association for the Study of the Liver (President 1997)
  • International Association for the Study of the Liver (Member)
  • British Liver Trust, Member of Medical Advisory Committee, (1990- 1995)
  • British Liver Trust, Vice President, 1993- present
  • Hepatitis B Foundation: Trustee 2005-present
  • Royal College of Physicians: member of Council and Executive Committee 2001- 2004
  • British Society of gastroenterology: member of Council 2002- 2005

JOURNALS

Member of the Editorial Boards of:

  • Hepatology, 1983-1985
  • Alimentary Pharmacology, 1987 - 1997
  • Interferons, Today and Tomorrow, 1987
  • Quarterly Journal of Medicine, 1989-1992
  • Clinical Science, 1998- 2001
  • J Hepatology 1999- 2001

Editor of Journal of Viral Hepatitis, 1993 - present

Editor of Textbook of ' Viral Hepatitis' 1st,2nd and 3rd editions published by Blackwells

MEMBERSHIP OF INTERNATIONAL COMMITTEES

  • WHO Adviser and Rapporteur on Chronic Liver Disease, Geneva, 1982
  • Member of Expert Advisory Group, International Union Against Cancer, Geneva, 1982
  • WHO Adviser on Antiviral Drugs, Geneva, 1987, 1992
  • Member of EC EuroHep Committee 1990-1996
  • Member of Scientific Committee of European Society for The Study of The Liver 1990-1993
  • WHO Adviser on Hepatitis C, Geneva, 1998
  • Member of Review Board of Australian Hepatitis C Strategy June 2002
  • Member of International Advisory Panel for German HepNet 2001-2003

CHAIRMANSHIP AND MEMBERSHIP OF NATIONAL COMMITTEES

  • Previous Member of UK Advisory Panel for Health Care Workers infected with blood borne viruses
  • Previous Member of DoH Advisory Panel for Microbiological Safety of Blood and Tissues for Transplantation
  • Member (1987-1997) and then  Chairman (1997-2009) of DoH Advisory Group on Viral Hepatitis;
  • Chairman of DoH Steering Group on Hepatitis C National Strategy (2003-2005);
  • Member of National Expert Panel on New Emerging Infections 2003 – 2009

ACADEMIC DISTINCTIONS

  • Research Medal British Society of Gastroenterology, 1984
  • Humphrey Davy Rolleston Lecturer of the Royal College of Physicians, 1986
  • Cohen Lecturer, Israel. 1988
  • Sheila Sherlock Research Prize, Toronto University, 1988
  • Hans Popper International Award for Distinction in Hepatology, Basel,1989
  • Bushell Lectureship of the Australian Society of Gastroenterology 1990
  • State of the Art Lecture of the Japanese Society of Gastroenterology 1991
  • Hans Popper Lecture, International Association for Study of Liver, Cape Town, 1996 
  • State of the Art Lecture of the German Society of Gastroenterology 1997
  • Medal to Celebrate “100years of virology” from Russian Academy of Medical Sciences and D.I.Ivanovsky Institute of Virology 1997
  • Fellow of  Academy of  Medical Science 1999
  • Life Time Recognition award of European Society for Study of the Liver Vienna 2010
  • Life Time Recognition Award of British Association for Study of the Liver Edinburgh 2010

PUBLICATIONS

I have published over 450 papers on the subjects of:

  • oral tolerance
  • molecular virology of HBV and HCV
  • pathogenesis of chronic HBV and HCV, most recently looking at genetic factors influencing outcome of HBV and HCV infection
  • pathogenesis of  autoimmune liver disease
  • approaches to therapy of HBV and HCV
  • epidemiology of cholangiocarcinoma and hepatocellular carcinoma
  • cognitive and MRS abnormalities in chronic HCV infection and demonstration that HCV infects the CNS
  • identification of genetic factors that influence alcoholism, NASH and drug induced liver injury by ENU mutagenesis

RESEARCH

My main contributions include:

 

Publications

Journals

Papatheodoridis G, Thomas HC, Golna C, et al., 2016, Addressing barriers to the prevention, diagnosis and treatment of hepatitis B and C in the face of persisting fiscal constraints in Europe: report from a high level conference, Journal of Viral Hepatitis, Vol:23, ISSN:1352-0504, Pages:1-12

Bermingham SL, Hughes R, Fenu E, et al., 2015, Cost-Effectiveness Analysis of Alternative Antiviral Strategies for the Treatment of HBeAg-Positive and HBeAg-Negative Chronic Hepatitis B in the United Kingdom, Value in Health, Vol:18, ISSN:1098-3015, Pages:800-809

Bridge SH, Sheridan DA, Felmlee DJ, et al., 2015, PCSK9, apolipoprotein E and lipoviral particles in chronic hepatitis C genotype 3: Evidence for genotype-specific regulation of lipoprotein metabolism, Journal of Hepatology, Vol:62, ISSN:0168-8278, Pages:763-770

Conference

Walsh R, Hammond R, Yuen L, et al., 2015, Mapping HBsAg epitope profiles to predict HBsAg loss/seroconversion in a treatment naive cohort of genotype A chronic hepatitis B (CHB) patients receiving tenofovir disoproxil fumarate (TDF) therapy, 66th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD), WILEY-BLACKWELL, Pages:966A-967A, ISSN:0270-9139

Lim LY, Yuen L, Hammond R, et al., 2014, Mapping the HBsAg immune phenotype to predict HBsAg loss or decline in chronic hepatitis B in patients receiving nucleot(s)ide analogue therapy, 65th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases, WILEY-BLACKWELL, Pages:980A-980A, ISSN:0270-9139

More Publications