Imperial College London

ProfessorHowardThomas

Faculty of MedicineDepartment of Medicine

Emeritus Professor of Hepatology
 
 
 
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Contact

 

+44 (0)20 3312 6454h.thomas

 
 
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Assistant

 

Ms Dawn Campbell +44 (0)20 3312 6454

 
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Location

 

1049 and 1050Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Summary

CURRICULUM VITAE

DATE OF BIRTH: 31 July 1945

DEGREES AND QUALIFICATIONS

  • B.Sc. Class II, Division I, Honours in Physiology
  • Newcastle Upon Tyne, 1966
  • M.B., B.S. with Honours - Newcastle Upon Tyne, 1969
  • Ph.D in Medicine - Glasgow University, 1974
  • Fellow of the Royal College of Physicians - London, 1983
  • Fellow of the Royal College of Physicians and Surgeons, Glasgow, 1984
  • Fellow of the Royal College of Pathologists - London, 1991
  • Fellow of  Academy of  Medical Science 1999

PAST AND PRESENT SENIOR APPOINTMENTS

  • Wellcome Senior Research Fellow in Clinical Science 1978-1983
  • Reader in Medicine, Royal Free Hospital Medical School, London University, 1983-1984
  • Titular Professor of Medicine, Royal Free Hospital Medical School, London University, 1984-1987
  • Professor and Chairman of Medicine, St Marys Hospital Medical School, London University, 1987-1997
  • Professor of Medicine and Head of Department of Medicine A; Deputy Chairman of Division of Medicine; Imperial College School of Medicine; and Consultant Physician/Hepatologist, St Marys Hospital, London, 1997- 2003
  • Dean (Clinical), Faculty of Medicine, Imperial College, 2001- 2004
  • Professor of Medicine and Head of Section of Hepatology and Gastroenterology; Imperial College School of Medicine; and Consultant Physician/Hepatologist, St Marys Hospital, London, 2003- present.

MEMBER/OFFICER  OF LEARNED SOCIETIES

  • Association of Physicians of Great Britain and Ireland (Member)
  • British Association for the Study of the Liver, President 1996-1998
  • European Association for the Study of the Liver (President 1997)
  • International Association for the Study of the Liver (Member)
  • British Liver Trust, Member of Medical Advisory Committee, (1990- 1995)
  • British Liver Trust, Vice President, 1993- present
  • Hepatitis B Foundation: Trustee 2005-present
  • Royal College of Physicians: member of Council and Executive Committee 2001- 2004
  • British Society of gastroenterology: member of Council 2002- 2005

JOURNALS

Member of the Editorial Boards of:

  • Hepatology, 1983-1985
  • Alimentary Pharmacology, 1987 - 1997
  • Interferons, Today and Tomorrow, 1987
  • Quarterly Journal of Medicine, 1989-1992
  • Clinical Science, 1998- 2001
  • J Hepatology 1999- 2001

Editor of Journal of Viral Hepatitis, 1993 - present

Editor of Textbook of ' Viral Hepatitis' 1st,2nd and 3rd editions published by Blackwells

MEMBERSHIP OF INTERNATIONAL COMMITTEES

  • WHO Adviser and Rapporteur on Chronic Liver Disease, Geneva, 1982
  • Member of Expert Advisory Group, International Union Against Cancer, Geneva, 1982
  • WHO Adviser on Antiviral Drugs, Geneva, 1987, 1992
  • Member of EC EuroHep Committee 1990-1996
  • Member of Scientific Committee of European Society for The Study of The Liver 1990-1993
  • WHO Adviser on Hepatitis C, Geneva, 1998
  • Member of Review Board of Australian Hepatitis C Strategy June 2002
  • Member of International Advisory Panel for German HepNet 2001-2003

CHAIRMANSHIP AND MEMBERSHIP OF NATIONAL COMMITTEES

  • Previous Member of UK Advisory Panel for Health Care Workers infected with blood borne viruses
  • Previous Member of DoH Advisory Panel for Microbiological Safety of Blood and Tissues for Transplantation
  • Member (1987-1997) and then  Chairman (1997-2009) of DoH Advisory Group on Viral Hepatitis;
  • Chairman of DoH Steering Group on Hepatitis C National Strategy (2003-2005);
  • Member of National Expert Panel on New Emerging Infections 2003 – 2009

ACADEMIC DISTINCTIONS

  • Research Medal British Society of Gastroenterology, 1984
  • Humphrey Davy Rolleston Lecturer of the Royal College of Physicians, 1986
  • Cohen Lecturer, Israel. 1988
  • Sheila Sherlock Research Prize, Toronto University, 1988
  • Hans Popper International Award for Distinction in Hepatology, Basel,1989
  • Bushell Lectureship of the Australian Society of Gastroenterology 1990
  • State of the Art Lecture of the Japanese Society of Gastroenterology 1991
  • Hans Popper Lecture, International Association for Study of Liver, Cape Town, 1996 
  • State of the Art Lecture of the German Society of Gastroenterology 1997
  • Medal to Celebrate “100years of virology” from Russian Academy of Medical Sciences and D.I.Ivanovsky Institute of Virology 1997
  • Fellow of  Academy of  Medical Science 1999
  • Life Time Recognition award of European Society for Study of the Liver Vienna 2010
  • Life Time Recognition Award of British Association for Study of the Liver Edinburgh 2010

PUBLICATIONS

I have published over 450 papers on the subjects of:

  • oral tolerance
  • molecular virology of HBV and HCV
  • pathogenesis of chronic HBV and HCV, most recently looking at genetic factors influencing outcome of HBV and HCV infection
  • pathogenesis of  autoimmune liver disease
  • approaches to therapy of HBV and HCV
  • epidemiology of cholangiocarcinoma and hepatocellular carcinoma
  • cognitive and MRS abnormalities in chronic HCV infection and demonstration that HCV infects the CNS
  • identification of genetic factors that influence alcoholism, NASH and drug induced liver injury by ENU mutagenesis

RESEARCH

My main contributions include:

 

Publications

Journals

Grieve R, Roberts J, Wright M, et al., 2007, Related Articles, Links Cost effectiveness of interferon alpha or peginterferon alpha with ribavirin for histologically mild chronic hepatitis C. Gut. 2006 Sep;55(9):1332-8., Gut, Vol:55, Pages:1332-1338

Wadsworth CA, Dixon PH, Taylor-Robinso SD, et al., 2018, Polymorphisms in Natural Killer Cell Receptor Protein 2D (NKG2D) as a Risk Factor for Cholangiocarcinoma, Journal of Clinical and Experimental Hepatology, ISSN:0973-6883

Papatheodoridis G, Thomas HC, Golna C, et al., 2016, Addressing barriers to the prevention, diagnosis and treatment of hepatitis B and C in the face of persisting fiscal constraints in Europe: report from a high level conference, Journal of Viral Hepatitis, Vol:23, ISSN:1352-0504, Pages:1-12

Bermingham SL, Hughes R, Fenu E, et al., 2015, Cost-Effectiveness Analysis of Alternative Antiviral Strategies for the Treatment of HBeAg-Positive and HBeAg-Negative Chronic Hepatitis B in the United Kingdom, Value in Health, Vol:18, ISSN:1098-3015, Pages:800-809

Bridge SH, Sheridan DA, Felmlee DJ, et al., 2015, PCSK9, apolipoprotein E and lipoviral particles in chronic hepatitis C genotype 3: Evidence for genotype-specific regulation of lipoprotein metabolism, Journal of Hepatology, Vol:62, ISSN:0168-8278, Pages:763-770

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