Imperial College London
Alternate

Hilary Watt CStat FHEA MSc MA(Oxon) BA

Faculty of Medicine, School of Public Health

Senior Teaching Fellow in Statistics
 
 
 
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Contact

 

+44 (0)20 7594 7451h.watt Website

 
 
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Location

 

322Reynolds BuildingCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Norheim:2018:10.1016/j.vaccine.2018.01.031,
author = {Norheim, G and Mueller, JE and Njanpop-Lafourcade, B-M and Delrieu, I and Findlow, H and Borrow, R and Xie, O and Nagaputra, J and Ramasamy, R and Dold, C and Tamekloe, TA and Rollier, CS and Watt, H and Kere, AB and Næss, LM and Pollard, AJ},
doi = {10.1016/j.vaccine.2018.01.031},
journal = {Vaccine},
pages = {1297--1303},
title = {Natural immunity against capsular group X N. meningitidis following an outbreak in Togo, 2007},
url = {http://dx.doi.org/10.1016/j.vaccine.2018.01.031},
volume = {36},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Capsular group X N. meningitidis (MenX) has emerged as a cause of localized disease outbreaks in sub-Saharan Africa, but the human immune response following exposure to MenX antigens is poorly described. We therefore assessed the natural immunity against MenX in individuals who were living in an area affected by a MenX outbreak during 2007 in Togo, West Africa. During 2009, 300 healthy individuals (100 aged 3-5years, 100 aged 13-19years and 100 aged 20-25years) were included in the study, and serum responses were compared with sera from age-matched controls from the U.K. and Burkina Faso. METHODS: MenX serum bactericidal antibody (SBA) was measured using rabbit complement, and antibodies against MenX polysaccharide (XPS) and outer membrane vesicles (XOMVs) were quantified by ELISA. RESULTS: The proportion of Togolese individuals with an SBA titer of ≥8 against the MenX strain was 29% (95% confidence interval (CI) 18-41) among those aged 3-5years, 34% (95% CI 9-60) among those aged 13-19years and 32% (95% CI 24-40) among those aged 20-25years. These were significantly higher than observed in the control populations from the U.K (range 13-16%) and Burkina Faso (range 2-6%). CONCLUSION: In Togolese individuals, the concentration of serum IgG against XPS was higher among the two older age groups as compared to the youngest age group. Antibody concentrations against MenX PS correlated significantly with SBA titers. This supports further development of a MenX PS based conjugate vaccine. Further studies are needed to verify the ability of MenX PS to induce SBA in humans.
AU  - Norheim,G
AU  - Mueller,JE
AU  - Njanpop-Lafourcade,B-M
AU  - Delrieu,I
AU  - Findlow,H
AU  - Borrow,R
AU  - Xie,O
AU  - Nagaputra,J
AU  - Ramasamy,R
AU  - Dold,C
AU  - Tamekloe,TA
AU  - Rollier,CS
AU  - Watt,H
AU  - Kere,AB
AU  - Næss,LM
AU  - Pollard,AJ
DO  - 10.1016/j.vaccine.2018.01.031
EP  - 1303
PY  - 2018///
SN  - 0264-410X
SP  - 1297
TI  - Natural immunity against capsular group X N. meningitidis following an outbreak in Togo, 2007
T2  - Vaccine
UR  - http://dx.doi.org/10.1016/j.vaccine.2018.01.031
UR  - http://hdl.handle.net/10044/1/56884
VL  - 36
ER  -
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