Imperial College London

Professor Hashim Ahmed

Faculty of MedicineDepartment of Surgery & Cancer

Chair in Urology (Clinical)
 
 
 
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Contact

 

hashim.ahmed

 
 
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Location

 

5L28Lab BlockCharing Cross Campus

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Summary

 

Summary

Professor Hashim Ahmed is currently Chair of Urology at Imperial College London. Hashim is an internationally renowned expert in prostate cancer diagnosis, imaging and biopsy as well as minimally invasive therapies for prostate cancer such as HIFU and cryotherapy – either whole-gland or focal therapy for primary prostate cancer or radiorecurrent disease. He has taught dozens of surgeons in these techniques in the UK and around the world and given numerous invited international lectures in this area. He has an extensive research portfolio with about £6M in grant income as a principal applicant and co-applicant to a research programme of approximately £14M. He has published over 150 peer-reviewed papers in areas that have led to key changes in the way we diagnose and treat men with localised prostate cancer. He currently holds a £2.1M Wellcome Trust Senior Clinical Research Fellowship and is Director of the Wellcome Trust Prostate Research in Imaging and Surgical Methodology (PRISM) Programme.

Detailed Biography

Hashim qualified from the University of Oxford where he attended St Peters College and Linacre College. Whilst he was a student he was awarded the William Osler Prize in Medicine. He then held house office posts in Queen Elizabeth Hospital, Birmingham and University Hospitals Manchester before returning to Oxford for an Anatomy Prosector post. Hashim then held senior house jobs in surgery on the Royal Free Hospital, London rotation followed by specialist registrar posts at West Middlesex Hospital, Charing Cross Hospital/Imperial College, University College Hospital and Watford General Hospital as part of the Imperial College Urology Rotation.

He was a Pelican Cancer Foundation Research Fellow followed by a MRC Clinician Research Training fellowship at University College London at which time a number of imaging and focal therapy trials were started. His research interests are in Health Technology Evaluation including multi-parametric MRI, Histoscanning, Tissue Type Imaging, as well as therapeutic interventions such as high intensity focused ultrasound, irreversible electroporation, photodynamic therapy, cryotherapy and radiofrequency ablation. He has completed numerous phase I/II clinical trials evaluating the role of focal therapy in prostate cancer and is lead PI and Co-PI in a number of multicentre trials including the UK NIHR-HTA funded study NCRN PROMIS study evaluating the role of multi-parametric MRI in men with a raised PSA using Template Prostate Mapping as the reference standard as well as NCRN INDEX, a multicentre focal therapy study using HIFU with 3 year follow-up and NCRN FORECAST. He previously held a £1.2M MRC Clinician Scientist Fellowship for 5 years and currently holds a £2M Senior Clinical Research Fellowship from the Wellcome Trust. His total grant income is £5M as lead applicant and £8M in total as co-applicant.

He has been visiting professor to UCLA, Tokyo, Weill-Cornell and Detroit universities and has given over 30 plenary lectures at national and international urology, oncology and imaging meetings.

The team he led recently was awarded the BMJ/BMA Innovation Award 2015 and the Health Services Journal Acute Sector Innovation Award 2016.

He holds a number of committee positions:

- Chair, ICTU-Surgery Trials Forum

- Member, Executive Committee for European Association of Urology Research Foundation

- Chair, Localised Disease Subgroup, NCRI Prostate Clinical Studies Group
- Member, NCRI Screening Prevention Early Diagnosis (SPED) Group
- Consulting Editor in Imaging, British Journal of Urology International
- Editorial Board, European Urology

Research interests

  • Prostate Diagnosis using novel imaging and tissue biomarkers
  • Prostate treatments that reduce the harms of traditional surgery and radiotherapy
  • Clinical trials and health technology evaluation

Selected Publications

Journal Articles

Wilt TJ, Ahmed HU, 2013, Prostate cancer screening and the management of clinically localized disease, British Medical Journal, Vol:346, ISSN:1756-1833

Bass EJ, Ahmed HU, 2016, Focal therapy in prostate cancer: A review of seven common controversies, Cancer Treatment Reviews, Vol:51, ISSN:0305-7372, Pages:27-34

Ahmed HU, Kirkham A, Arya M, et al., 2009, Is it time to consider a role for MRI before prostate biopsy?, Nature Reviews Clinical Oncology, Vol:6, ISSN:1759-4774, Pages:197-206

Ahmed HU, Emberton M, 2010, Is focal therapy the future for prostate cancer?, Future Oncology, Vol:6, ISSN:1479-6694, Pages:261-268

Ahmed HU, Freeman A, Kirkham A, et al., 2011, Focal Therapy for Localized Prostate Cancer: A Phase I/II Trial, Journal of Urology, Vol:185, ISSN:0022-5347, Pages:1246-1254

Ahmed HU, Hu Y, Carter T, et al., 2011, Characterizing Clinically Significant Prostate Cancer Using Template Prostate Mapping Biopsy, Journal of Urology, Vol:186, ISSN:0022-5347, Pages:458-464

Ahmed HU, Hindley RG, Dickinson L, et al., 2012, Focal therapy for localised unifocal and multifocal prostate cancer: a prospective development study, Lancet Oncology, Vol:13, ISSN:1470-2045, Pages:622-632

Ahmed HU, Arya M, Freeman A, et al., 2012, Do low-grade and low-volume prostate cancers bear the hallmarks of malignancy?, Lancet Oncology, Vol:13, ISSN:1470-2045, Pages:E509-E517

Singh PB, Anele C, Dalton E, et al., 2014, Prostate Cancer Tumour Features on Template Prostate-mapping Biopsies: Implications for Focal Therapy, European Urology, Vol:66, ISSN:0302-2838, Pages:12-19

Valerio M, Donaldson I, Emberton M, et al., 2015, Detection of Clinically Significant Prostate Cancer Using Magnetic Resonance Imaging-Ultrasound Fusion Targeted Biopsy: A Systematic Review, European Urology, Vol:68, ISSN:0302-2838, Pages:8-19

Ahmed HU, Dickinson L, Charman S, et al., 2015, Focal Ablation Targeted to the Index Lesion in Multifocal Localised Prostate Cancer: a Prospective Development Study, European Urology, Vol:68, ISSN:0302-2838, Pages:927-936

Valerio M, McCartan N, Freeman A, et al., 2015, Visually directed vs. software-based targeted biopsy compared to transperineal template mapping biopsy in the detection of clinically significant prostate cancer, Urologic Oncology, Vol:33, ISSN:1078-1439

Dickinson L, Arya M, Afzal N, et al., 2016, Medium- term Outcomes after Whole-gland High-intensity Focused Ultrasound for the Treatment of Nonmetastatic Prostate Cancer from a Multicentre Registry Cohort, European Urology, Vol:70, ISSN:0302-2838, Pages:668-674

Ahmed HU, Bosaily AE-S, Brown LC, et al., 2017, Diagnostic accuracy of multi-parametric MRI and TRUS biopsy in prostate cancer (PROMIS): a paired validating confirmatory study, The Lancet, Vol:389, ISSN:0140-6736, Pages:815-822

Ahmed HU, 2018, Opening Our Eyes to Multiparametric Magnetic Resonance Imaging Before Prostate Biopsy, European Urology, Vol:73, ISSN:0302-2838, Pages:361-362

Simmons LAM, Kanthabalan A, Arya M, et al., 2017, The PICTURE study: diagnostic accuracy of multiparametric MRI in men requiring a repeat prostate biopsy, British Journal of Cancer, Vol:116, ISSN:0007-0920, Pages:1159-1165

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