Imperial College London

Professor Hashim Ahmed

Faculty of MedicineDepartment of Surgery & Cancer

Chair in Urology (Clinical)
 
 
 
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Contact

 

hashim.ahmed

 
 
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Location

 

5L28Lab BlockCharing Cross Campus

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Summary

 

Publications

Publication Type
Year
to

257 results found

Afaq A, Alahmed S, Chen S-H, Lengana T, Haroon A, Payne H, Ahmed H, Punwani S, Sathekge M, Bomanji Jet al., 2018, Impact of Ga-68-Prostate-Specific Membrane Antigen PET/CT on Prostate Cancer Management, JOURNAL OF NUCLEAR MEDICINE, Vol: 59, Pages: 89-92, ISSN: 0161-5505

JOURNAL ARTICLE

Ahmed HU, 2018, Opening Our Eyes to Multiparametric Magnetic Resonance Imaging Before Prostate Biopsy, EUROPEAN UROLOGY, Vol: 73, Pages: 361-362, ISSN: 0302-2838

JOURNAL ARTICLE

Appayya MB, Sidhu HS, Dikaios N, Johnston EW, Simons LAM, Freeman A, Kirkham APS, Ahmed HU, Punwani Set al., 2018, Characterizing indeterminate (Likert-score 3/5) peripheral zone prostate lesions with PSA density, PI-RADS scoring and qualitative descriptors on multiparametric MRI, BRITISH JOURNAL OF RADIOLOGY, Vol: 91, ISSN: 0007-1285

JOURNAL ARTICLE

Bonmati E, Hu Y, Villarini B, Rodell R, Martin P, Han L, Donaldson I, Ahmed HU, Moore CM, Emberton M, Barratt DCet al., 2018, Technical Note: Error metrics for estimating the accuracy of needle/instrument placement during transperineal magnetic resonance/ultrasound-guided prostate interventions., Med Phys

PURPOSE: Image-guided systems that fuse magnetic resonance imaging (MRI) with three-dimensional (3D) ultrasound (US) images for performing targeted prostate needle biopsy and minimally invasive treatments for prostate cancer are of increasing clinical interest. To date, a wide range of different accuracy estimation procedures and error metrics have been reported, which makes comparing the performance of different systems difficult. METHODS: A set of nine measures are presented to assess the accuracy of MRI-US image registration, needle positioning, needle guidance, and overall system error, with the aim of providing a methodology for estimating the accuracy of instrument placement using a MR/US-guided transperineal approach. RESULTS: Using the SmartTarget fusion system, an MRI-US image alignment error was determined to be 2.0 ± 1.0 mm (mean ± SD), and an overall system instrument targeting error of 3.0 ± 1.2 mm. Three needle deployments for each target phantom lesion was found to result in a 100% lesion hit rate and a median predicted cancer core length of 5.2 mm. CONCLUSIONS: The application of a comprehensive, unbiased validation assessment for MR/US guided systems can provide useful information on system performance for quality assurance and system comparison. Furthermore, such an analysis can be helpful in identifying relationships between these errors, providing insight into the technical behavior of these systems.

JOURNAL ARTICLE

Faria R, Soares MO, Spackman E, Ahmed HU, Brown LC, Kaplan R, Emberton M, Sculpher MJet al., 2018, Optimising the Diagnosis of Prostate Cancer in the Era of Multiparametric Magnetic Resonance Imaging: A Cost-effectiveness Analysis Based on the Prostate MR Imaging Study (PROMIS), EUROPEAN UROLOGY, Vol: 73, Pages: 23-30, ISSN: 0302-2838

JOURNAL ARTICLE

Faria R, Soares MO, Spackman E, Ahmed HU, Brown LC, Kaplan R, Emberton M, Sculpher MJet al., 2018, Re: Jochen Walz. The "PROMIS" of Magnetic Resonance Imaging Cost Effectiveness in Prostate Cancer Diagnosis? Eur Urol 2018;73:31-2., Eur Urol

JOURNAL ARTICLE

Grey A, Scott R, Charman S, van der Meulen J, Frinking P, Acher P, Liyanage S, Madaan S, Constantinescu G, Shah B, Graves CB, Freeman A, Jameson C, Ramachandran N, Emberton M, Arya M, Ahmed HUet al., 2018, The CADMUS trial - Multi-parametric ultrasound targeted biopsies compared to multi-parametric MRI targeted biopsies in the diagnosis of clinically significant prostate cancer, CONTEMPORARY CLINICAL TRIALS, Vol: 66, Pages: 86-92, ISSN: 1551-7144

JOURNAL ARTICLE

Kasivisvanathan V, Ahmed H, Cashman S, Challacombe B, Emberton M, Gao C, Lamb BW, Nambiar A, Pickard R, Shah TT, Smith Det al., 2018, The British Urology Researchers in Surgical Training (BURST) Research Collaborative: an alternative research model for carrying out large scale multi-centre urological studies, BJU INTERNATIONAL, Vol: 121, Pages: 6-9, ISSN: 1464-4096

JOURNAL ARTICLE

Peters M, Kanthabalan A, Shah TT, McCartan N, Moore CM, Arya M, van Zyp JRVDV, Moerland MA, Hindley RG, Emberton M, Ahmed HUet al., 2018, Development and internal validation of prediction models for biochemical failure and composite failure after focal salvage high intensity focused ultrasound for local radiorecurrent prostate cancer: Presentation of risk scores for individual patient prognoses, UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, Vol: 36, ISSN: 1078-1439

JOURNAL ARTICLE

Rouhani MJ, Burleigh EJ, Hobbis C, Dunford C, Osman NI, Gan C, Gibbons NB, Ahmed HU, Miah Set al., 2018, UK medical students' perceptions, attitudes, and interest toward medical leadership and clinician managers, ADVANCES IN MEDICAL EDUCATION AND PRACTICE, Vol: 9, Pages: 119-124, ISSN: 1179-7258

JOURNAL ARTICLE

Walker NAF, Norris JM, Shah TT, Yap T, Cathcart P, Moore CM, Ahmed HU, Emberton M, Minhas Set al., 2018, A comparison of time taken to return to baseline erectile function following focal and whole gland ablative therapies for localized prostate cancer: A systematic review, UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, Vol: 36, Pages: 67-76, ISSN: 1078-1439

JOURNAL ARTICLE

Ahmed HU, Bosaily AE-S, Brown LC, Gabe R, Kaplan R, Parmar MK, Collaco-Moraes Y, Ward K, Hindley RG, Freeman A, Kirkham AP, Oldroyd R, Parker C, Emberton Met al., 2017, Diagnostic accuracy of multi-parametric MRI and TRUS biopsy in prostate cancer (PROMIS): a paired validating confirmatory study, LANCET, Vol: 389, Pages: 815-822, ISSN: 0140-6736

JOURNAL ARTICLE

Ahmed HU, Brown LC, Kaplan R, Parker C, Emberton Met al., 2017, Diagnostic accuracy of the PROMIS study Reply, LANCET, Vol: 390, Pages: 362-362, ISSN: 0140-6736

JOURNAL ARTICLE

Bass EJ, Donaldson IA, Freeman A, Jameson C, Punwani S, Moore C, Arya M, Emberton M, Ahmed HUet al., 2017, Magnetic resonance imaging targeted transperineal prostate biopsy: a local anaesthetic approach, PROSTATE CANCER AND PROSTATIC DISEASES, Vol: 20, Pages: 311-317, ISSN: 1365-7852

JOURNAL ARTICLE

Borghesi M, Ahmed H, Nam R, Schaeffer E, Schiavina R, Taneja S, Weidner W, Loeb Set al., 2017, Complications After Systematic, Random, and Image-guided Prostate Biopsy, EUROPEAN UROLOGY, Vol: 71, Pages: 353-365, ISSN: 0302-2838

JOURNAL ARTICLE

Davda R, Prentice M, Sarova A, Nei W, Orczyk C, Arya M, Moore C, Ahmed H, Emberton M, Mitra A, Payne Het al., 2017, Late Toxicity and Patient Reported Outcomes in Patients Treated With Salvage Radiation Following Primary High Intensity Focal Ultrasound for Localized Prostate Cancer, 59th Annual Meeting of the American-Society-for-Therapeutic-Radiation-Oncology (ASTRO), Publisher: ELSEVIER SCIENCE INC, Pages: E226-E226, ISSN: 0360-3016

CONFERENCE PAPER

Dickinson L, Ahmed HU, Hindley RG, McCartan N, Freeman A, Allen C, Emberton M, Kirkham APet al., 2017, Prostate-specific antigen vs. magnetic resonance imaging parameters for assessing oncological outcomes after high intensity-focused ultrasound focal therapy for localized prostate cancer, UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, Vol: 35, ISSN: 1078-1439

JOURNAL ARTICLE

Dikaios N, Atkinson D, Tudisca C, Purpura P, Forster M, Ahmed H, Beale T, Emberton M, Punwani Set al., 2017, A comparison of Bayesian and non-linear regression methods for robust estimation of pharmacokinetics in DCE-MRI and how it affects cancer diagnosis, COMPUTERIZED MEDICAL IMAGING AND GRAPHICS, Vol: 56, Pages: 1-10, ISSN: 0895-6111

JOURNAL ARTICLE

Edison E, Shah TT, Ahmed HU, 2017, Focal Ablation of Early-Stage Prostate Cancer Candidate Selection, Treatment Guidance, and Assessment of Outcome, UROLOGIC CLINICS OF NORTH AMERICA, Vol: 44, Pages: 575-+, ISSN: 0094-0143

JOURNAL ARTICLE

Faria R, Soares M, Spackman E, Ahmed H, Brown L, Rs K, Emberton M, Sculpher Met al., 2017, COST-EFFECTIVENESS OF DIAGNOSIS: FROM TESTS TO LONG-TERM OUTCOMES AND COSTS, Publisher: ELSEVIER SCIENCE INC, Pages: A405-A406, ISSN: 1098-3015

CONFERENCE PAPER

Georgiou PS, Jaros J, Payne H, Allen C, Shah TT, Ahmed HU, Gibson E, Barratt D, Treeby BEet al., 2017, Beam distortion due to gold fiducial markers during salvage high-intensity focused ultrasound in the prostate, MEDICAL PHYSICS, Vol: 44, Pages: 679-693, ISSN: 0094-2405

JOURNAL ARTICLE

Grey ADR, Ahmed HU, 2017, Re: Limitations of Elastography Based Prostate Biopsy, JOURNAL OF UROLOGY, Vol: 197, Pages: 263-264, ISSN: 0022-5347

JOURNAL ARTICLE

Hindley RG, Mistry K, Ahmed HU, 2017, The PROMIS of a New Diagnostic Pathway for Men with Suspected Prostate Cancer., Clin Oncol (R Coll Radiol), Vol: 29, Pages: 397-400

JOURNAL ARTICLE

Hu Y, Kasivisvanathan V, Simmons LAM, Clarkson MJ, Thompson SA, Shah TT, Ahmed HU, Punwani S, Hawkes DJ, Emberton M, Moore CM, Barratt DCet al., 2017, Development and Phantom Validation of a 3-D-Ultrasound-Guided System for Targeting MRI-Visible Lesions During Transrectal Prostate Biopsy, IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, Vol: 64, Pages: 946-958, ISSN: 0018-9294

JOURNAL ARTICLE

Kanthabalan A, Peters M, Van Vulpen M, McCartan N, Hindley RG, Emara A, Moore CM, Arya M, Emberton M, Ahmed HUet al., 2017, Focal salvage high-intensity focused ultrasound in radiorecurrent prostate cancer, BJU INTERNATIONAL, Vol: 120, Pages: 246-256, ISSN: 1464-4096

JOURNAL ARTICLE

Linch M, Goh G, Hiley C, Shanmugabavan Y, McGranahan N, Rowan A, Wong YNS, King H, Furness A, Freeman A, Linares J, Akarca A, Herrero J, Rosenthal R, Harder N, Schmidt G, Wilson GA, Birkbak NJ, Mitter R, Dentro S, Cathcart P, Arya M, Johnston E, Scott R, Hung M, Emberton M, Attard G, Szallasi Z, Punwani S, Quezada SA, Marafioti T, Gerlinger M, Ahmed HU, Swanton Cet al., 2017, Intratumoural evolutionary landscape of high-risk prostate cancer: the PROGENY study of genomic and immune parameters, ANNALS OF ONCOLOGY, Vol: 28, Pages: 2472-2480, ISSN: 0923-7534

JOURNAL ARTICLE

MacLennan S, Williamson PR, Bekema H, Campbell M, Ramsay C, N'Dow J, MacLennan S, Vale L, Dahm P, Mottet N, Lam T, COMPACTERS Study Groupet al., 2017, A core outcome set for localised prostate cancer effectiveness trials., BJU Int, Vol: 120, Pages: E64-E79

OBJECTIVE: To develop a core outcome set (COS) applicable for effectiveness trials of all interventions for localised prostate cancer. Many treatments exist for localised prostate cancer, although it is unclear which offers the optimal therapeutic ratio; which is confounded by inconsistencies in the selection, definition, measurement and reporting of outcomes in clinical trials. PATIENTS, SUBJECTS AND METHODS: A list of 79 outcomes was derived from a systematic review of published localised prostate cancer effectiveness studies and semi-structured interviews with 15 patients with prostate cancer patients. A two-stage consensus process involving 118 patients and 56 international healthcare professionals (HCPs; cancer specialist nurses, urological surgeons and oncologists) was undertaken, consisting of a three-round Delphi survey followed by a face-to-face consensus panel meeting of 13 HCPs and eight patients. RESULTS: The final COS included 19 outcomes. In all, 12 apply to all interventions: death from prostate cancer, death from any cause, local disease recurrence, distant disease recurrence/metastases, disease progression, need for salvage therapy, overall quality of life, stress urinary incontinence, urinary function, bowel function, faecal incontinence, and sexual function. Seven were intervention-specific: perioperative deaths (surgery), positive surgical margin (surgery), thromboembolic disease (surgery), bothersome or symptomatic urethral or anastomotic stricture (surgery), need for curative treatment (active surveillance), treatment failure (ablative therapy), and side-effects of hormonal therapy (hormone therapy). The UK-centric participants may limit the generalisability to other countries, but trialists should reason why the COS would not be applicable. The default position should not be that a COS developed in one country will automatically not be applicable elsewhere. CONCLUSION: We have established a COS for trials of effectiveness in localised prostate

JOURNAL ARTICLE

Miah S, Ahmed HU, 2017, The death of ink: the value of typing skills as an addition to the medical school curriculum, ADVANCES IN MEDICAL EDUCATION AND PRACTICE, Vol: 8, Pages: 701-702, ISSN: 1179-7258

JOURNAL ARTICLE

Moore CM, Robertson NL, Jichi F, Damola A, Ambler G, Giganti F, Ridout AJ, Bott SRJ, Winkler M, Ahmed HU, Arya M, Mitra AV, McCartan N, Freeman A, Jameson C, Castro R, Gambarota G, Whitcher BJ, Allen C, Kirkham A, Emberton Met al., 2017, The Effect of Dutasteride on Magnetic Resonance Imaging Defined Prostate Cancer: MAPPED-A Randomized, Placebo Controlled, Double-Blind Clinical Trial, JOURNAL OF UROLOGY, Vol: 197, Pages: 1006-1013, ISSN: 0022-5347

JOURNAL ARTICLE

Segaran SV, Emara AM, Mahesan T, Silverman J, Ahmed HU, Bott SRJ, Hindley RGet al., 2017, The ability of free to total prostate-specific antigen and prostate-specific antigen density to detect clinically significant prostate cancer in men undergoing transperineal template biopsy, JOURNAL OF CLINICAL UROLOGY, Vol: 10, Pages: 529-534, ISSN: 2051-4158

JOURNAL ARTICLE

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