Imperial College London

Professor Hashim Ahmed

Faculty of MedicineDepartment of Surgery & Cancer

Chair in Urology (Clinical)
 
 
 
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Contact

 

hashim.ahmed

 
 
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Location

 

5L28Lab BlockCharing Cross Campus

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Summary

 

Publications

Publication Type
Year
to

282 results found

Ahmed HU, 2016, Focal Laser Ablation of Prostate Cancer: Phase I Clinical Trial EDITORIAL COMMENT, JOURNAL OF UROLOGY, Vol: 196, Pages: 74-75, ISSN: 0022-5347

JOURNAL ARTICLE

Ahmed HU, 2016, The PROMIS of MRI, BJU INTERNATIONAL, Vol: 118, Pages: 7-7, ISSN: 1464-4096

JOURNAL ARTICLE

Bass EJ, Ahmed HU, 2016, Focal therapy in prostate cancer: A review of seven common controversies, CANCER TREATMENT REVIEWS, Vol: 51, Pages: 27-34, ISSN: 0305-7372

JOURNAL ARTICLE

Bosaily AE-S, Valerio M, Hu Y, Freeman A, Jameson C, Brown L, Kaplan R, Hindley RG, Barratt D, Emberton M, Ahmed HUet al., 2016, The concordance between the volume hotspot and the grade hotspot: a 3-D reconstructive model using the pathology outputs from the PROMIS trial, PROSTATE CANCER AND PROSTATIC DISEASES, Vol: 19, Pages: 258-263, ISSN: 1365-7852

JOURNAL ARTICLE

Dickinson L, Arya M, Afzal N, Cathcart P, Charman SC, Cornaby A, Hindley RG, Lewi H, McCartan N, Moore CM, Nathan S, Ogden C, Persad R, van der Meulen J, Weir S, Emberton M, Ahmed HUet al., 2016, Medium- term Outcomes after Whole-gland High-intensity Focused Ultrasound for the Treatment of Nonmetastatic Prostate Cancer from a Multicentre Registry Cohort, EUROPEAN UROLOGY, Vol: 70, Pages: 668-674, ISSN: 0302-2838

JOURNAL ARTICLE

Grey A, Ahmed HU, 2016, Multiparametric ultrasound in the diagnosis of prostate cancer, CURRENT OPINION IN UROLOGY, Vol: 26, Pages: 114-119, ISSN: 0963-0643

JOURNAL ARTICLE

Hamid S, Guillaumier S, Shah T, Arya M, Ahmed HUet al., 2016, PROSTATE CANCER RECURRENCE AFTER FOCAL THERAPY: TREATMENT OPTIONS, ARCHIVOS ESPANOLES DE UROLOGIA, Vol: 69, Pages: 375-383, ISSN: 0004-0614

JOURNAL ARTICLE

Haroon A, Ahmed HU, Cathcart P, Almuhaideb A, Kayani I, Dickson J, Kirkham A, Freeman A, Emberton M, Bomanji Jet al., 2016, 18F-FECH PET/CT to Assess Clinically Significant Disease in Prostate Cancer: Correlation With Maximum and Total Cancer Core Length Obtained via MRI-Guided Template Mapping Biopsies., AJR Am J Roentgenol, Vol: 207, Pages: 1297-1306

OBJECTIVE: The objective of this study was to detect clinically significant and insignificant prostate cancer on 18F-fluoroethylcholine (FECH) PET/CT and to correlate findings with transperineal template-guided prostate mapping (TPM) biopsy. SUBJECTS AND METHODS: Fifty-six lobes of the prostate were analyzed in 28 men who underwent FECH PET/CT and TPM. Whole-body images and pelvic images were acquired at 60 and 90 minutes after tracer administration. FECH PET/CT findings were correlated with TPM. Sensitivity, specificity, positive predictive values, negative predictive values, and AUC of dual phase FECH PET/CT were calculated. RESULTS: Mean age of the patients was 68.8 years (range, 53-79 years), and mean prostate-specific antigen level was 12.1 ng/mL (range, 0.6-45 ng/mL). Mean maximum cancer core length was 4.4 mm (median, 4 mm; range, 1-14 mm) and mean total cancer core length, 14.6 mm (median, 14.6 mm; range, 1-82 mm). Prostate cancer was identified in 38 lobes with a Gleason score of 6 in five lobes (13%), 7 in 27 lobes (71%), 8 in four lobes (11%), and 9 in two lobes (5%). FECH PET/CT showed findings of prostate cancer in 46/56 lobes (82%). The ranges for maximum standardized uptake value for 60- and 90-minute FECH PET/CT were 1.3-11.4 and 1.2-10.9, respectively. Clinically significant cancer was seen in 30 of 38 positive lobes; eight had clinically insignificant disease. For 60-minute imaging, the sensitivity, specificity, and ROC AUC were 75%, 75%, and 0.746 (95% CI, 0.612-0.853). For 90-minute imaging, the sensitivity, specificity, and ROC AUC were 73.7%, 58.3%, and 0.646 (95% CI, 0.498-0.776). Overall sensitivity, specificity, positive predictive value, and negative predictive value were 95%, 50%, 82.6%, and 80%, respectively. CONCLUSION: FECH PET/CT can detect prostate cancer and localizes TPM biopsy-proven clinically significant prostate cancer with sensitivity of greater than 89.7%. Of the two imaging durations, 60-minute imaging is more sensitive and s

JOURNAL ARTICLE

Jarow JP, Ahmed HU, Choyke PL, Taneja SS, Scardino PTet al., 2016, Partial Gland Ablation for Prostate Cancer: Report of a Food and Drug Administration, American Urological Association, and Society of Urologic Oncology Public Workshop, UROLOGY, Vol: 88, Pages: 8-13, ISSN: 0090-4295

JOURNAL ARTICLE

Johnston E, Pye H, Bonet-Carne E, Panagiotaki E, Patel D, Galazi M, Heavey S, Carmona L, Freeman A, Trevisan G, Allen C, Kirkham A, Burling K, Stevens N, Hawkes D, Emberton M, Moore C, Ahmed HU, Atkinson D, Rodriguez-Justo M, Ng T, Alexander D, Whitaker H, Punwani Set al., 2016, INNOVATE: A prospective cohort study combining serum and urinary biomarkers with novel diffusion-weighted magnetic resonance imaging for the prediction and characterization of prostate cancer, BMC CANCER, Vol: 16, ISSN: 1471-2407

JOURNAL ARTICLE

Kanthabalan A, Abd-Alazeez M, Arya M, Allen C, Freeman A, Jameson C, Kirkham A, Mitra AV, Payne H, Punwani S, Ramachandran N, Walkden M, Emberton M, Ahmed HUet al., 2016, Transperineal Magnetic Resonance Imaging-targeted Biopsy versus Transperineal Template Prostate Mapping Biopsy in the Detection of Localised Radio-recurrent Prostate Cancer, CLINICAL ONCOLOGY, Vol: 28, Pages: 568-576, ISSN: 0936-6555

JOURNAL ARTICLE

Miah S, Ahmed HU, Freeman A, Emberton Met al., 2016, Does true Gleason pattern 3 merit its cancer descriptor?, NATURE REVIEWS UROLOGY, Vol: 13, Pages: 541-548, ISSN: 1759-4812

JOURNAL ARTICLE

Peters M, van Zyp JRNVDV, Moerland MA, Hoekstra CJ, van de Pol S, Westendorp H, Maenhout M, Kattevilder R, Verkooijen HM, van Rossum PSN, Ahmed HU, Shah TT, Emberton M, van Vulpen Met al., 2016, Development and internal validation of a multivariable prediction model for biochemical failure after whole-gland salvage iodine-125 prostate brachytherapy for recurrent prostate cancer, BRACHYTHERAPY, Vol: 15, Pages: 296-305, ISSN: 1538-4721

JOURNAL ARTICLE

Peters M, van Zyp JRNVDV, Moerland MA, Hoekstra CJ, van de Pol S, Westendorp H, Maenhout M, Kattevilder R, Verkooijen HM, van Rossum PSN, Ahmed HU, Shah TT, Emberton M, van Vulpen Met al., 2016, Multivariable model development and internal validation for prostate cancer specific survival and overall survival after whole-gland salvage Iodine-125 prostate brachytherapy, RADIOTHERAPY AND ONCOLOGY, Vol: 119, Pages: 104-110, ISSN: 0167-8140

JOURNAL ARTICLE

Shah TT, Arbel U, Foss S, Zachman A, Rodney S, Ahmed HU, Arya Met al., 2016, Modeling Cryotherapy Ice Ball Dimensions and Isotherms in a Novel Gel-based Model to Determine Optimal Cryo-needle Configurations and Settings for Potential Use in Clinical Practice, UROLOGY, Vol: 91, Pages: 234-240, ISSN: 0090-4295

JOURNAL ARTICLE

Shah TT, Peters M, Kanthabalan A, McCartan N, Fatola Y, van Zyp JVDV, van Vulpen M, Freeman A, Moore CM, Arya M, Emberton M, Ahmed HUet al., 2016, PSA nadir as a predictive factor for biochemical disease-free survival and overall survival following whole-gland salvage HIFU following radiotherapy failure, PROSTATE CANCER AND PROSTATIC DISEASES, Vol: 19, Pages: 311-316, ISSN: 1365-7852

JOURNAL ARTICLE

Valerio M, Anele C, Bott SRJ, Charman SC, van der Meulen J, El-Mahallawi H, Emara AM, Freeman A, Jameson C, Hindley RG, Montgomery BSI, Singh PB, Ahmed HU, Emberton Met al., 2016, The Prevalence of Clinically Significant Prostate Cancer According to Commonly Used Histological Thresholds in Men Undergoing Template Prostate Mapping Biopsies, JOURNAL OF UROLOGY, Vol: 195, Pages: 1403-1408, ISSN: 0022-5347

JOURNAL ARTICLE

Valerio M, Anele C, Charman SC, van der Meulen J, Freeman A, Jameson C, Singh PB, Emberton M, Ahmed HUet al., 2016, Transperineal template prostate-mapping biopsies: an evaluation of different protocols in the detection of clinically significant prostate cancer, BJU INTERNATIONAL, Vol: 118, Pages: 384-390, ISSN: 1464-4096

JOURNAL ARTICLE

Valerio M, Emberton M, Eggener SE, Ahmed HUet al., 2016, The challenging landscape of medical device approval in localized prostate cancer, NATURE REVIEWS UROLOGY, Vol: 13, Pages: 91-98, ISSN: 1759-4812

JOURNAL ARTICLE

Yap T, Ahmed HU, Hindley RG, Guillaumier S, McCartan N, Dickinson L, Emberton M, Minhas Set al., 2016, The Effects of Focal Therapy for Prostate Cancer on Sexual Function: A Combined Analysis of Three Prospective Trials, EUROPEAN UROLOGY, Vol: 69, Pages: 844-851, ISSN: 0302-2838

JOURNAL ARTICLE

Abd-Alazeez M, Ramachandran N, Dikaios N, Ahmed HU, Emberton M, Kirkham A, Arya M, Taylor S, Halligan S, Punwani Set al., 2015, Multiparametric MRI for detection of radiorecurrent prostate cancer: added value of apparent diffusion coefficient maps and dynamic contrast-enhanced images, PROSTATE CANCER AND PROSTATIC DISEASES, Vol: 18, Pages: 128-136, ISSN: 1365-7852

JOURNAL ARTICLE

Abel M, Ahmed H, Leen E, Park E, Chen M, Wasan H, Price P, Monzon L, Gedroyc W, Abel Pet al., 2015, Ultrasound-guided trans-rectal highintensity focused ultrasound (HIFU) for advanced cervical cancer ablation is feasible: a case report, JOURNAL OF THERAPEUTIC ULTRASOUND, Vol: 3, ISSN: 2050-5736

JOURNAL ARTICLE

Ahmed HU, Dickinson L, Charman S, Weir S, McCartan N, Hindley RG, Freeman A, Kirkham AP, Sahu M, Scott R, Allen C, Van der Meulen J, Emberton Met al., 2015, Focal Ablation Targeted to the Index Lesion in Multifocal Localised Prostate Cancer: a Prospective Development Study, EUROPEAN UROLOGY, Vol: 68, Pages: 927-936, ISSN: 0302-2838

JOURNAL ARTICLE

Al-Qaisieh B, Mason J, Bownes P, Henry A, Dickinson L, Ahmed HU, Emberton M, Langley Set al., 2015, Dosimetry Modeling for Focal Low-Dose-Rate Prostate Brachytherapy, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, Vol: 92, Pages: 787-793, ISSN: 0360-3016

JOURNAL ARTICLE

Anastasiadis E, Ahmed HU, Relton C, Emberton Met al., 2015, A novel randomised controlled trial design in prostate cancer, BJU INTERNATIONAL, Vol: 116, Pages: 6-8, ISSN: 1464-4096

JOURNAL ARTICLE

Anastasiadis E, Charman SC, Arumainayagam N, Sohaib AS, Allen C, Freeman A, Emberton M, Ahmed HUet al., 2015, What Burden of Prostate Cancer Can Radiologists Rule Out on Multiparametric Magnetic Resonance Imaging? A Sensitivity Analysis Based on Varying the Target Condition in Template Prostate Mapping Biopsies, UROLOGY, Vol: 86, Pages: 544-551, ISSN: 0090-4295

JOURNAL ARTICLE

Bastianpillai C, Petrides N, Shah T, Guillaumier S, Ahmed HU, Arya Met al., 2015, Harnessing the immunomodulatory effect of thermal and non-thermal ablative therapies for cancer treatment, TUMOR BIOLOGY, Vol: 36, Pages: 9137-9146, ISSN: 1010-4283

JOURNAL ARTICLE

Bosaily AE-S, Arya M, Punwani S, Emberton M, Kirkham A, Freeman A, Ahmed HUet al., 2015, Re: Multiparametric Magnetic Resonance Imaging Guided Diagnostic Biopsy Detects Significant Prostate Cancer and could Reduce Unnecessary Biopsies and Over Detection: A Prospective Study, JOURNAL OF UROLOGY, Vol: 193, Pages: 735-736, ISSN: 0022-5347

JOURNAL ARTICLE

Bosaily AE-S, Parker C, Brown LC, Gabe R, Hindley RG, Kaplan R, Emberton M, Ahmed HUet al., 2015, PROMIS - Prostate MR imaging study: A paired validating cohort study evaluating the role of multi-parametric MRI in men with clinical suspicion of prostate cancer, CONTEMPORARY CLINICAL TRIALS, Vol: 42, Pages: 26-40, ISSN: 1551-7144

JOURNAL ARTICLE

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