Imperial College London

Professor Hashim Ahmed

Faculty of MedicineDepartment of Surgery & Cancer

Chair in Urology (Clinical)
 
 
 
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Contact

 

hashim.ahmed

 
 
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Location

 

5L28Lab BlockCharing Cross Campus

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Summary

 

Publications

Publication Type
Year
to

286 results found

Karavitakis M, Ahmed HU, Abel PD, Hazell S, Winkler MHet al., 2012, Anatomically versus biologically unifocal prostate cancer: a pathological evaluation in the context of focal therapy., Ther Adv Urol, Vol: 4, Pages: 155-160

OBJECTIVES: Since tumor focality in prostate cancer continues to be considered a major limitation for focal prostate therapy, in this study we attempted to compare the pathological features and the proportion of patients with anatomically unifocal versus biologically unifocal tumors (i.e. multifocal prostate cancer in which the secondary nonindex elements are small, low grade and clinically insignificant) who were suitable for focal therapy. METHODS: Ninety-five consecutive whole mount laparoscopic radical prostatectomy samples underwent pathological assessment (from January 2007 to November 2009). Tumor focality, laterality, Gleason score and volume of individual foci, total tumor volume, pathological stage and surgical margin status were assessed. The index lesion was defined as the largest by volume. Patients suitable for focal ablation were defined as having tumors that were unifocal, organ confined, with a Gleason score (GS) up to 7 prostate cancer, or multifocal, organ confined, GS up to 7 prostate cancer, with one large index lesion and the remaining foci demonstrating features of clinically insignificant disease (total tumor volume of all secondary foci ≤0.5 cm(3) with GS ≤ 6). RESULTS: Patients with biologically unifocal cancer had significantly lower total tumor volume (3.26 versus 7.28 cm(3); p < 0.001), index lesion volume (2.9 versus 7.16 cm(3); p < 0.001), rates of seminal vesicle invasion (4% versus 34%; p < 0.001), rates of positive surgical margins (22.4% versus 52.1%; p < 0.001) and rates of 4+3 GS tumors (10.2% versus 29.1%; p = 0.018). The proportion of patients suitable for focal therapy was higher in the biologically unifocal versus anatomically unifocal cancer group, although without reaching statistical significance (65.3% versus 45.8%; p = 0.11). CONCLUSIONS: Patients with biologically unifocal tumors have better pathological outcome than those with anatomically unifocal disease. At present the assumption that multifocality

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Ahmed HU, Emberton M, 2012, Focal HIFU for prostate cancer Reply, LANCET ONCOLOGY, Vol: 13, Pages: E284-E284, ISSN: 1470-2045

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Ahmed HU, Cathcart P, Chalasani V, Williams A, McCartan N, Freeman A, Kirkham A, Allen C, Chin J, Emberton Met al., 2012, Whole-gland salvage high-intensity focused ultrasound therapy for localized prostate cancer recurrence after external beam radiation therapy, CANCER, Vol: 118, Pages: 3071-3078, ISSN: 0008-543X

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Punwani S, Emberton M, Walkden M, Sohaib A, Freeman A, Ahmed H, Allen C, Kirkham Aet al., 2012, Prostatic cancer surveillance following whole-gland high-intensity focused ultrasound: comparison of MRI and prostate-specific antigen for detection of residual or recurrent disease, BRITISH JOURNAL OF RADIOLOGY, Vol: 85, Pages: 720-728, ISSN: 0007-1285

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Ahmed HU, Hindley RG, Dickinson L, Freeman A, Kirkham AP, Sahu M, Scott R, Allen C, Van der Meulen J, Emberton Met al., 2012, Focal therapy for localised unifocal and multifocal prostate cancer: a prospective development study, LANCET ONCOLOGY, Vol: 13, Pages: 622-632, ISSN: 1470-2045

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Ahmed HU, Akin O, Coleman JA, Crane S, Emberton M, Goldenberg L, Hricak H, Kattan MW, Kurhanewicz J, Moore CM, Parker C, Polascik TJ, Scardino P, van As N, Villers Aet al., 2012, Transatlantic Consensus Group on active surveillance and focal therapy for prostate cancer, BJU INTERNATIONAL, Vol: 109, Pages: 1636-1647, ISSN: 1464-4096

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Abd Alazeez M, Ahmed HU, Anastasiadis E, Arya M, Kirkham A, Emberton Met al., 2012, Can multi-parametric MRI prior to first TRUS biopsy rule out clinically important prostate cancer? A validating cohort study using template prostate mapping as a reference test, Annual Scientific Meeting of the British-Association-of-Urological-Surgeons (BAUS), Publisher: WILEY-BLACKWELL, Pages: 17-17, ISSN: 1464-4096

CONFERENCE PAPER

Karavitakis M, Ahmed HU, Abel PD, Hazell S, Winkler MHet al., 2012, Margin Status After Laparoscopic Radical Prostatectomy and the Index Lesion: Implications for Preoperative Evaluation of Tumor Focality in Prostate Cancer, JOURNAL OF ENDOUROLOGY, Vol: 26, Pages: 503-508, ISSN: 0892-7790

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Ahmed HU, Emberton M, Kepner G, Kepner Jet al., 2012, A biomedical engineering approach to mitigate the errors of prostate biopsy, NATURE REVIEWS UROLOGY, Vol: 9, Pages: 227-U81, ISSN: 1759-4812

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Simmons L, Kirkham A, Ramachandran N, Moore C, Ahmed H, Emberton Met al., 2012, 'Cognitive' MRI-guided TRUS biopsy targeting - does it require specialist radiological expertise?, INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, Vol: 66, Pages: 3-3, ISSN: 1368-5031

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Hu Y, Ahmed HU, Taylor Z, Allen C, Emberton M, Hawkes D, Barratt Det al., 2012, MR to ultrasound registration for image-guided prostate interventions, MEDICAL IMAGE ANALYSIS, Vol: 16, Pages: 687-703, ISSN: 1361-8415

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Ahmed HU, 2012, Focal Therapy Will Become Standard Treatment for Localized Prostate Cancer, JOURNAL OF UROLOGY, Vol: 187, Pages: 792-794, ISSN: 0022-5347

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Abd Alazeez M, Ahmed H, Moore C, Kirkham A, Freeman A, Emberton Met al., 2012, The Role of mp-MRI in the Detection of Prostate Cancer, CLINICAL ONCOLOGY, Vol: 24, Pages: 154-154, ISSN: 0936-6555

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Ahmed HU, Emberton M, 2012, URINARY INCONTINENCE AFTER PROSTATE CANCER Image guided diagnosis and treatment to prevent incontinence after radical prostatectomy, BRITISH MEDICAL JOURNAL, Vol: 344, ISSN: 0959-535X

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Parker C, Kaplan RS, Gabe R, Ahmed HU, Rantell K, Emberton Met al., 2012, Multiparametric magnetic resonance imaging in the diagnosis and characterisation of prostate cancer: The PROMIS study, JOURNAL OF CLINICAL ONCOLOGY, Vol: 30, ISSN: 0732-183X

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Langley S, Ahmed HU, Al-Qaisieh B, Bostwick D, Dickinson L, Gomez Veiga F, Grimm P, Machtens S, Guedea F, Emberton Met al., 2012, Report of a consensus meeting on focal low dose rate brachytherapy for prostate cancer, BJU INTERNATIONAL, Vol: 109, Pages: 7-16, ISSN: 1464-4096

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Ahmed HU, Gabe R, Kaplan R, Parker C, Emberton Met al., 2012, Multi-parametric magnetic resonance imaging in the diagnosis and characterization of prostate cancer prior to first biopsy in men at risk: The PROMIS study, EUROPEAN UROLOGY SUPPLEMENTS, Vol: 11, Pages: E824-U743, ISSN: 1569-9056

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Ahmed HU, Arumainayagam N, Kirkham AP, Allen C, Sohaib SA, Freeman A, Emberton Met al., 2012, What burden of prostate cancer can radiologists rule-out on multi-parametric MRI? An analysis based on template prostate mapping biopsies as the reference standard, EUROPEAN UROLOGY SUPPLEMENTS, Vol: 11, Pages: E795-U685, ISSN: 1569-9056

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Ahmed HU, Singh P, Dalton E, Stevens D, Barbouti O, Gurung P, Freeman A, Emberton Met al., 2012, Patterns of prostate cancer on template prostate mapping biopsies in 291 men: Implications for focal therapy, EUROPEAN UROLOGY SUPPLEMENTS, Vol: 11, Pages: E22-U334, ISSN: 1569-9056

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Dickinson L, Hu Y, Carter T, Ahmed HU, Allen C, Kirkham A, Emberton M, Barratt Det al., 2012, MR-directed selective HIFU therapy of prostate cancer using a TRUS guidance platform, EUROPEAN UROLOGY SUPPLEMENTS, Vol: 11, Pages: E24-U338, ISSN: 1569-9056

JOURNAL ARTICLE

Karavitakis M, Ahmed HU, Abel PD, Livni N, Hazell S, Winkler MHet al., 2012, Evolution of the pathological outcomes after radical prostatectomy with increasing use of active surveillance in the UK: Implication for focal therapy, EUROPEAN UROLOGY SUPPLEMENTS, Vol: 11, Pages: E20-U330, ISSN: 1569-9056

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Stevens DJ, Moore C, Ahmed H, Allen C, Kirkham A, Van der Meulen J, Emberton Met al., 2012, The natural history of untreated prostate MRI lesions in an active surveillance prostate cancer population-260 patient-years, EUROPEAN UROLOGY SUPPLEMENTS, Vol: 11, Pages: E1096-U281, ISSN: 1569-9056

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Hu Y, Carter TJ, Ahmed HU, Emberton M, Allen C, Hawkes DJ, Barratt DCet al., 2011, Modelling Prostate Motion for Data Fusion During Image-Guided Interventions, IEEE TRANSACTIONS ON MEDICAL IMAGING, Vol: 30, Pages: 1887-1900, ISSN: 0278-0062

JOURNAL ARTICLE

Karavitakis M, Winkler MH, Abel PD, Hazell S, Ahmed HUet al., 2011, Focal Therapy for Prostate Cancer: Opportunities and Uncertainties, DISCOVERY MEDICINE, Vol: 12, Pages: 245-255, ISSN: 1539-6509

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Monzon L, Wasan H, Leen E, Ahmed H, Dawson PM, Harvey C, Muhamed A, Hand J, Price P, Abel PDet al., 2011, Transrectal high-intensity focused ultrasonography is feasible as a new therapeutic option for advanced recurrent rectal cancer: report on the first case worldwide., Ann R Coll Surg Engl, Vol: 93, Pages: e119-e121

High-intensity focused ultrasonography is the only completely non-invasive thermal therapy. To date its applications have been limited but clinical indications are expanding with enhanced technological advances that have increased the accuracy of targeting and decreased the duration of treatment times. We report its first use for rectal cancer.

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Ahmed HU, Hu Y, Carter T, Arumainayagam N, Lecornet E, Freeman A, Hawkes D, Barratt DC, Emberton Met al., 2011, Characterizing Clinically Significant Prostate Cancer Using Template Prostate Mapping Biopsy, JOURNAL OF UROLOGY, Vol: 186, Pages: 458-464, ISSN: 0022-5347

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Singh PB, Ahmed HU, Stevens D, Barbouti O, Arumainayagam N, Freeman A, Emberton Met al., 2011, Template transperineal prostate mapping biopsies prostate cancer risk stratification and cancer localization, Annual Meeting of the Society-of-Academic-and-Research-Surgeons, Publisher: WILEY-BLACKWELL, Pages: E10-E10, ISSN: 0007-1323

CONFERENCE PAPER

Ahmed H, Emberton M, Cathcart P, McCartan Net al., 2011, Focal salvage high-intensity focused ultrasound ablation therapy (Sonoblate 500TM) following failed external beam radiation therapy to the prostate, Annual Meeting of the Society-of-Academic-and-Research-Surgeons, Publisher: WILEY-BLACKWELL, Pages: E5-E5, ISSN: 0007-1323

CONFERENCE PAPER

Ahmed H, Emberton M, Cathcart P, McCartan Net al., 2011, Whole-gland salvage therapy using high-intensity focused ultrasound (sonoblate 500tm) for presumed local recurrence following external beam radiation therapy to the prostate, Annual Meeting of the Society-of-Academic-and-Research-Surgeons, Publisher: WILEY-BLACKWELL, Pages: E4-E4, ISSN: 0007-1323

CONFERENCE PAPER

Ahmed HU, Freeman A, Kirkham A, Sahu M, Scott R, Allen C, Van der Meulen J, Emberton Met al., 2011, Focal Therapy for Localized Prostate Cancer: A Phase I/II Trial, JOURNAL OF UROLOGY, Vol: 185, Pages: 1246-1254, ISSN: 0022-5347

JOURNAL ARTICLE

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