Imperial College London

Professor Hashim Ahmed

Faculty of MedicineDepartment of Surgery & Cancer

Chair in Urology (Clinical)
 
 
 
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Contact

 

hashim.ahmed

 
 
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Location

 

5L28Lab BlockCharing Cross Campus

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Summary

 

Publications

Publication Type
Year
to

282 results found

Hu Y, Ahmed HU, Carter T, Arumainayagam N, Lecornet E, Barzell W, Freeman A, Nevoux P, Hawkes DJ, Villers A, Emberton M, Barratt DCet al., 2012, A biopsy simulation study to assess the accuracy of several transrectal ultrasonography (TRUS)-biopsy strategies compared with template prostate mapping biopsies in patients who have undergone radical prostatectomy, BJU INTERNATIONAL, Vol: 110, Pages: 812-820, ISSN: 1464-4096

JOURNAL ARTICLE

Hu Y, Ahmed HU, Taylor Z, Allen C, Emberton M, Hawkes D, Barratt Det al., 2012, MR to ultrasound registration for image-guided prostate interventions, MEDICAL IMAGE ANALYSIS, Vol: 16, Pages: 687-703, ISSN: 1361-8415

JOURNAL ARTICLE

Karavitakis M, Ahmed HU, Abel PD, Hazell S, Winkler MHet al., 2012, Margin Status After Laparoscopic Radical Prostatectomy and the Index Lesion: Implications for Preoperative Evaluation of Tumor Focality in Prostate Cancer, JOURNAL OF ENDOUROLOGY, Vol: 26, Pages: 503-508, ISSN: 0892-7790

JOURNAL ARTICLE

Karavitakis M, Ahmed HU, Abel PD, Hazell S, Winkler MHet al., 2012, Anatomically versus biologically unifocal prostate cancer: a pathological evaluation in the context of focal therapy., Ther Adv Urol, Vol: 4, Pages: 155-160

OBJECTIVES: Since tumor focality in prostate cancer continues to be considered a major limitation for focal prostate therapy, in this study we attempted to compare the pathological features and the proportion of patients with anatomically unifocal versus biologically unifocal tumors (i.e. multifocal prostate cancer in which the secondary nonindex elements are small, low grade and clinically insignificant) who were suitable for focal therapy. METHODS: Ninety-five consecutive whole mount laparoscopic radical prostatectomy samples underwent pathological assessment (from January 2007 to November 2009). Tumor focality, laterality, Gleason score and volume of individual foci, total tumor volume, pathological stage and surgical margin status were assessed. The index lesion was defined as the largest by volume. Patients suitable for focal ablation were defined as having tumors that were unifocal, organ confined, with a Gleason score (GS) up to 7 prostate cancer, or multifocal, organ confined, GS up to 7 prostate cancer, with one large index lesion and the remaining foci demonstrating features of clinically insignificant disease (total tumor volume of all secondary foci ≤0.5 cm(3) with GS ≤ 6). RESULTS: Patients with biologically unifocal cancer had significantly lower total tumor volume (3.26 versus 7.28 cm(3); p < 0.001), index lesion volume (2.9 versus 7.16 cm(3); p < 0.001), rates of seminal vesicle invasion (4% versus 34%; p < 0.001), rates of positive surgical margins (22.4% versus 52.1%; p < 0.001) and rates of 4+3 GS tumors (10.2% versus 29.1%; p = 0.018). The proportion of patients suitable for focal therapy was higher in the biologically unifocal versus anatomically unifocal cancer group, although without reaching statistical significance (65.3% versus 45.8%; p = 0.11). CONCLUSIONS: Patients with biologically unifocal tumors have better pathological outcome than those with anatomically unifocal disease. At present the assumption that multifocality

JOURNAL ARTICLE

Karavitakis M, Ahmed HU, Abel PD, Livni N, Hazell S, Winkler MHet al., 2012, Trends in pathologic outcomes after introduction of active surveillance in the UK: Implication for focal therapy, PROSTATE, Vol: 72, Pages: 1464-1468, ISSN: 0270-4137

JOURNAL ARTICLE

Karavitakis M, Ahmed HU, Abel PD, Livni N, Hazell S, Winkler MHet al., 2012, Evolution of the pathological outcomes after radical prostatectomy with increasing use of active surveillance in the UK: Implication for focal therapy, EUROPEAN UROLOGY SUPPLEMENTS, Vol: 11, Pages: E20-U330, ISSN: 1569-9056

JOURNAL ARTICLE

Langley S, Ahmed HU, Al-Qaisieh B, Bostwick D, Dickinson L, Gomez Veiga F, Grimm P, Machtens S, Guedea F, Emberton Met al., 2012, Report of a consensus meeting on focal low dose rate brachytherapy for prostate cancer, BJU INTERNATIONAL, Vol: 109, Pages: 7-16, ISSN: 1464-4096

JOURNAL ARTICLE

Lecornet E, Ahmed HU, Hu Y, Moore CM, Nevoux P, Barratt D, Hawkes D, Villers A, Emberton Met al., 2012, The Accuracy of Different Biopsy Strategies for the Detection of Clinically Important Prostate Cancer: A Computer Simulation, JOURNAL OF UROLOGY, Vol: 188, Pages: 974-980, ISSN: 0022-5347

JOURNAL ARTICLE

Nevoux P, Ouzzane A, Ahmed HU, Emberton M, Montironi R, Presti JC, Villers Aet al., 2012, Quantitative tissue analyses of prostate cancer foci in an unselected cystoprostatectomy series, BJU INTERNATIONAL, Vol: 110, Pages: 517-523, ISSN: 1464-4096

JOURNAL ARTICLE

Parker C, Kaplan RS, Gabe R, Ahmed HU, Rantell K, Emberton Met al., 2012, Multiparametric magnetic resonance imaging in the diagnosis and characterisation of prostate cancer: The PROMIS study, JOURNAL OF CLINICAL ONCOLOGY, Vol: 30, ISSN: 0732-183X

JOURNAL ARTICLE

Punwani S, Emberton M, Walkden M, Sohaib A, Freeman A, Ahmed H, Allen C, Kirkham Aet al., 2012, Prostatic cancer surveillance following whole-gland high-intensity focused ultrasound: comparison of MRI and prostate-specific antigen for detection of residual or recurrent disease, BRITISH JOURNAL OF RADIOLOGY, Vol: 85, Pages: 720-728, ISSN: 0007-1285

JOURNAL ARTICLE

Simmons L, Autier P, Zat'ura F, Braeckman J, Peltier A, Romics I, Stenzl A, Ahmed H, Moore C, Emberton Met al., 2012, Prostate HistoScanning for the Detection, Localization and Volume Estimation of Prostate Cancer: PHS02, UROLOGY, Vol: 80, Pages: S15-S15, ISSN: 0090-4295

JOURNAL ARTICLE

Simmons L, Kirkham A, Ramachandran N, Moore C, Ahmed H, Emberton Met al., 2012, 'Cognitive' MRI-guided TRUS biopsy targeting - does it require specialist radiological expertise?, INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, Vol: 66, Pages: 3-3, ISSN: 1368-5031

JOURNAL ARTICLE

Simmons L, Ramachandran N, Kirkham A, Moore C, Ahmed H, Emberton Met al., 2012, Can Urologists Conduct MRI-Guided TRUS Biopsy Targeting?, UROLOGY, Vol: 80, Pages: S138-S138, ISSN: 0090-4295

JOURNAL ARTICLE

Simmons L, Robertson N, Ahmed H, Moore C, Emberton Met al., 2012, Inter-Operator Reliability of Prostate Histoscanning (TM) for the Characterisation of Prostate Cancer, UROLOGY, Vol: 80, Pages: S138-S139, ISSN: 0090-4295

JOURNAL ARTICLE

Stevens DJ, Moore C, Ahmed H, Allen C, Kirkham A, Van der Meulen J, Emberton Met al., 2012, The natural history of untreated prostate MRI lesions in an active surveillance prostate cancer population-260 patient-years, EUROPEAN UROLOGY SUPPLEMENTS, Vol: 11, Pages: E1096-U281, ISSN: 1569-9056

JOURNAL ARTICLE

Ahmed H, Emberton M, Cathcart P, McCartan Net al., 2011, Focal salvage high-intensity focused ultrasound ablation therapy (Sonoblate 500TM) following failed external beam radiation therapy to the prostate, Annual Meeting of the Society-of-Academic-and-Research-Surgeons, Publisher: WILEY-BLACKWELL, Pages: E5-E5, ISSN: 0007-1323

CONFERENCE PAPER

Ahmed H, Emberton M, Cathcart P, McCartan Net al., 2011, Whole-gland salvage therapy using high-intensity focused ultrasound (sonoblate 500tm) for presumed local recurrence following external beam radiation therapy to the prostate, Annual Meeting of the Society-of-Academic-and-Research-Surgeons, Publisher: WILEY-BLACKWELL, Pages: E4-E4, ISSN: 0007-1323

CONFERENCE PAPER

Ahmed HU, Cathcart P, McCartan N, Kirkham A, Allen C, Freeman A, Emberton Met al., 2011, FOCAL SALVAGE THERAPY COMPARED TO WHOLE-GLAND SALVAGE: A FEASIBILITY STUDY, EUROPEAN UROLOGY SUPPLEMENTS, Vol: 10, Pages: 92-93, ISSN: 1569-9056

JOURNAL ARTICLE

Ahmed HU, Freeman A, Kirkham A, Sahu M, Scott R, Allen C, Van der Meulen J, Emberton Met al., 2011, Focal Therapy for Localized Prostate Cancer: A Phase I/II Trial, JOURNAL OF UROLOGY, Vol: 185, Pages: 1246-1254, ISSN: 0022-5347

JOURNAL ARTICLE

Ahmed HU, Hu Y, Carter T, Arumainayagam N, Lecornet E, Freeman A, Hawkes D, Barratt DC, Emberton Met al., 2011, Characterizing Clinically Significant Prostate Cancer Using Template Prostate Mapping Biopsy, JOURNAL OF UROLOGY, Vol: 186, Pages: 458-464, ISSN: 0022-5347

JOURNAL ARTICLE

Arumainayagam N, Ahmed H, Moore C, Freeman A, Sohaib A, Kirkham A, Allen C, Emberton Met al., 2011, A NEGATIVE MULTI-PARAMETRIC MRI CAN RULE-OUT UP TO 97% OF CLINICALLY SIGNIFICANT PROSTATE CANCER, Publisher: ELSEVIER SCIENCE INC, Pages: E927-E928, ISSN: 0022-5347

CONFERENCE PAPER

Arumainayagam N, Ahmed HU, Moore CM, Freeman A, Sohaib A, Kirkham A, Allen C, Emberton Met al., 2011, A NEGATIVE MULTI-PARAMETRIC MRI CAN RULE OUT UP TO 97% OF CLINICALLY SIGNIFICANT PROSTATE CANCER, EUROPEAN UROLOGY SUPPLEMENTS, Vol: 10, Pages: 66-67, ISSN: 1569-9056

JOURNAL ARTICLE

Barzell W, Cathcart P, Moore C, Melamed M, Ahmed H, Emberton Met al., 2011, RE-CLASSIFICATION STRATEGIES IN MEN WITH LOW RISK PROSTATE CANCER: TRUS GUIDED BIOPSY VERSUS TEMPLATE PROSTATE MAPPING, EUROPEAN UROLOGY SUPPLEMENTS, Vol: 10, Pages: 176-176, ISSN: 1569-9056

JOURNAL ARTICLE

Dickinson L, Ahmed HU, Allen C, Barentsz JO, Carey B, Futterer JJ, Heijmink SW, Hoskin PJ, Kirkham A, Padhani AR, Persad R, Puech P, Punwani S, Sohaib AS, Tombal B, Villers A, van der Meulen J, Emberton Met al., 2011, Magnetic Resonance Imaging for the Detection, Localisation, and Characterisation of Prostate Cancer: Recommendations from a European Consensus Meeting, EUROPEAN UROLOGY, Vol: 59, Pages: 477-494, ISSN: 0302-2838

JOURNAL ARTICLE

Dickinson L, Ahmed HU, Cathcart P, Mccartan N, Moore CM, Kirkham A, Freeman A, Allen C, Emberton Met al., 2011, TRIFECTA OUTCOMES AFTER WHOLE-GLAND HIGH INTENSITY FOCUSED ULTRASOUND FOR THE TREATMENT OF LOCALISED PROSTATE CANCER: A REGISTRY-BASED ANALYSIS, EUROPEAN UROLOGY SUPPLEMENTS, Vol: 10, Pages: 281-281, ISSN: 1569-9056

JOURNAL ARTICLE

Hu Y, Carter TJ, Ahmed HU, Emberton M, Allen C, Hawkes DJ, Barratt DCet al., 2011, Modelling Prostate Motion for Data Fusion During Image-Guided Interventions, IEEE TRANSACTIONS ON MEDICAL IMAGING, Vol: 30, Pages: 1887-1900, ISSN: 0278-0062

JOURNAL ARTICLE

Karavitakis M, Ahmed HU, Abel PD, Hazell S, Winkler MHet al., 2011, Tumor focality in prostate cancer: implications for focal therapy, NATURE REVIEWS CLINICAL ONCOLOGY, Vol: 8, Pages: 48-55, ISSN: 1759-4774

JOURNAL ARTICLE

Karavitakis M, Ahmed HU, Abel PD, Hazell S, Winkler MHet al., 2011, RELATIONSHIP OF RADICAL PROSTATECTOMY MARGIN STATUS AND INDEX LESION: IMPLICATIONS FOR PREOPERATIVE EVALUATION OF TUMOUR FOCALITY IN PROSTATE CANCER, EUROPEAN UROLOGY SUPPLEMENTS, Vol: 10, Pages: 300-300, ISSN: 1569-9056

JOURNAL ARTICLE

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