Imperial College London
Portrait Picture

Professor Hashim Ahmed

Faculty of Medicine, Department of Surgery & Cancer

Chair in Urology (Clinical)
 
 
 
//

Contact

 

hashim.ahmed

 
 
//

Location

 

5L28Lab BlockCharing Cross Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Sidhu:2016:10.1007/s00330-016-4579-9,
author = {Sidhu, HS and Benigno, S and Ganeshan, B and Dikaios, N and Johnston, EW and Allen, C and Kirkham, A and Groves, AM and Ahmed, HU and Emberton, M and Taylor, SA and Halligan, S and Punwani, S},
doi = {10.1007/s00330-016-4579-9},
journal = {European Radiology},
pages = {2348--2358},
title = {"Textural analysis of multiparametric MRI detects transition zone prostate cancer"},
url = {http://dx.doi.org/10.1007/s00330-016-4579-9},
volume = {27},
year = {2016}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objectives To evaluate multiparametric-MRI (mpMRI) derivedhistogram textural-analysis parameters for detection oftransition zone (TZ) prostatic tumour.Methods Sixty-seven consecutive men with suspected prostatecancer underwent 1.5T mpMRI prior to template-mappingbiopsy(TPM). Twenty-six men had ‘significant’ TZ tumour.Two radiologists in consensus matched TPM to the single axialslice best depicting tumour, or largest TZ diameter for those withbenign histology, to define single-slice whole TZ-regions-ofinterest(ROIs). Textural-parameter differences between singleslicewhole TZ-ROI containing significant tumour versusbenign/insignificant tumour were analysed using MannWhitney U test. Diagnostic accuracy was assessed by receiveroperating characteristic area under curve (ROC-AUC) analysiscross-validated with leave-one-out (LOO) analysis.Results ADC kurtosis was significantly lower (p < 0.001) inTZ containing significant tumour with ROC-AUC 0.80(LOO-AUC 0.78); the difference became non-significant followingexclusion of significant tumour from single-slicewhole TZ-ROI (p = 0.23). T1-entropy was significantly lower(p = 0.004) in TZ containing significant tumour with ROCAUC0.70 (LOO-AUC 0.66) and was unaffected by excludingsignificant tumour from TZ-ROI (p = 0.004). Combiningthese parameters yielded ROC-AUC 0.86 (LOO-AUC 0.83).Conclusion Textural features of the whole prostate TZ candiscriminate significant prostatic cancer through reduced kurtosisof the ADC-histogram where significant tumour is includedin TZ-ROI and reduced T1 entropy independent oftumour inclusion.Key Points• MR textural features of prostate transition zone may discriminatesignificant prostatic cancer.• Transition zone (TZ) containing significant tumour demonstratesa less peaked ADC histogram.• TZ containing significant tumour reveals higher postcontrastT1-weighted homogeneity.• The utility of MR texture analysis in prostate cancer meritsfurther investigation.
AU  - Sidhu,HS
AU  - Benigno,S
AU  - Ganeshan,B
AU  - Dikaios,N
AU  - Johnston,EW
AU  - Allen,C
AU  - Kirkham,A
AU  - Groves,AM
AU  - Ahmed,HU
AU  - Emberton,M
AU  - Taylor,SA
AU  - Halligan,S
AU  - Punwani,S
DO  - 10.1007/s00330-016-4579-9
EP  - 2358
PY  - 2016///
SN  - 0938-7994
SP  - 2348
TI  - "Textural analysis of multiparametric MRI detects transition zone prostate cancer"
T2  - European Radiology
UR  - http://dx.doi.org/10.1007/s00330-016-4579-9
UR  - http://hdl.handle.net/10044/1/53557
VL  - 27
ER  -
Download