Imperial College London
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Professor Hashim Ahmed

Faculty of Medicine, Department of Surgery & Cancer

Chair in Urology (Clinical)
 
 
 
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Contact

 

hashim.ahmed

 
 
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Location

 

5L28Lab BlockCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Shah:2015:10.1007/s00345-015-1561-0,
author = {Shah, TT and Kasivisvanathan, V and Jameson, C and Freeman, A and Emberton, M and Ahmed, HU},
doi = {10.1007/s00345-015-1561-0},
journal = {World Journal of Urology},
pages = {955--964},
title = {Histological outcomes after focal high-intensity focused ultrasound and cryotherapy},
url = {http://dx.doi.org/10.1007/s00345-015-1561-0},
volume = {33},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - IntroductionFocal therapy has increasingly become an accepted treatment option for patients with localised prostate cancer. Most follow-up protocols use a mixture of protocol biopsies or “for cause” biopsies triggered by a rising PSA. In this paper, we discuss the histological outcomes from these biopsies and their use in guiding subsequent management and trial development.MethodsWe conducted a literature search and reviewed the post-treatment biopsy results from studies on focal HIFU and focal cryotherapy. We subsequently reviewed the results of three recently published consensus statements released discussing many of the issues concerning focal therapy.ResultsResearch suggests that 1 in 5 of all post-treatment biopsies after focal therapy are positive. However, the majority of these seemed to be from the untreated portion of the gland or met criteria for clinically insignificant disease. The histological outcomes from focal therapy are promising and confirm its effectiveness in the short to medium term. Furthermore re-treatment is possible whilst maintaining a low-side-effect profile.ConclusionDebate is ongoing about the clinical significance of various levels of residual disease after focal therapy and the exact threshold at which to call failure within a patient who has had focal therapy.
AU  - Shah,TT
AU  - Kasivisvanathan,V
AU  - Jameson,C
AU  - Freeman,A
AU  - Emberton,M
AU  - Ahmed,HU
DO  - 10.1007/s00345-015-1561-0
EP  - 964
PY  - 2015///
SN  - 0724-4983
SP  - 955
TI  - Histological outcomes after focal high-intensity focused ultrasound and cryotherapy
T2  - World Journal of Urology
UR  - http://dx.doi.org/10.1007/s00345-015-1561-0
UR  - http://hdl.handle.net/10044/1/53879
VL  - 33
ER  -
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