Imperial College London
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Professor Hashim Ahmed

Faculty of Medicine, Department of Surgery & Cancer

Chair in Urology (Clinical)
 
 
 
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Contact

 

hashim.ahmed

 
 
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Location

 

5L28Lab BlockCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Shah:2017:10.1080/14737140.2017.1383899,
author = {Shah, TT and To, WKL and Ahmed, HU},
doi = {10.1080/14737140.2017.1383899},
journal = {Expert Review of Anticancer Therapy},
pages = {1159--1168},
title = {Magnetic resonance imaging in the early detection of prostate cancer and review of the literature on magnetic resonance imaging-stratified clinical pathways},
url = {http://dx.doi.org/10.1080/14737140.2017.1383899},
volume = {17},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - INTRODUCTION: With level 1 evidence now available on the diagnostic accuracy of multiparametric magnetic resonance imaging (MRI) we must now utilise this data in developing an MRI-stratified diagnostic pathway for the early detection of prostate cancer. Areas covered: A literature review was conducted and identified seven randomised control trials (RCT's) assessing the diagnostic accuracy of such a pathway against the previously accepted systematic/random trans-rectal ultrasound guided (TRUS) biopsy pathway. The studies were heterogeneous in their design. Five studies assessed the addition of MRI-targeted biopsies to a standard care systematic TRUS biopsy pathway. Three of these studies showed either an increase in their diagnostic accuracy or the potential to remove systematic biopsies. Two studies looked specifically at a targeted biopsy only pathway and although the results were again mixed, there was no decrease in the diagnostic rate and overall significantly fewer biopsy cores were taken in the MRI group. Expert commentary: Results from these RCT's together with multiple retrospective and prospective studies point towards either an improved diagnostic rate for clinically significant cancer and/or a reduction in the need for systematic biopsies with a MRI-stratified pathway. The challenge for the urological community will be to implement pre-biopsy MRI into a routine clinical pathway with likely independent monitoring of standards.
AU  - Shah,TT
AU  - To,WKL
AU  - Ahmed,HU
DO  - 10.1080/14737140.2017.1383899
EP  - 1168
PY  - 2017///
SN  - 1473-7140
SP  - 1159
TI  - Magnetic resonance imaging in the early detection of prostate cancer and review of the literature on magnetic resonance imaging-stratified clinical pathways
T2  - Expert Review of Anticancer Therapy
UR  - http://dx.doi.org/10.1080/14737140.2017.1383899
UR  - https://www.ncbi.nlm.nih.gov/pubmed/28933973
UR  - http://hdl.handle.net/10044/1/53453
VL  - 17
ER  -
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