Imperial College London


Faculty of MedicineSchool of Public Health

Honorary Research Associate



+44 (0)20 7594 3277i.bakolis Website




531Norfolk PlaceSt Mary's Campus






BibTex format

author = {Garcia, Larsen V and Morton, V and Norat, T and Moreira, A and Potts, J and Bakolis, I},
doi = {10.1038/s41430-018-0234-7},
journal = {European Journal of Clinical Nutrition},
pages = {366--386},
title = {Dietary patterns derived from Principal Component Analysis (PCA) and the risk of colorectal cancer: a systematic review and meta-analysis},
url = {},
volume = {73},
year = {2018}

RIS format (EndNote, RefMan)

AB - Background and aim: Colorectal cancer [CRC] is highly prevalent worldwide, with dietary habits being a major risk factor. We systematically reviewed and meta-analysed the observational evidence on the association between CRC and dietary patterns [DP] derived from Principal Component Analysis.Design: PRISMA guidelines were followed. Web of Science, Medline/PubMed, EMBASE, and The Cochrane Library were searched to identify all eligible papers published up to July 2017. Any pre-defined cancer in the colon was included, namely colon-rectal cancer (CRC), colon cancer (CC), rectal cancer (RC), or proximal and distal CC, if available. Western (WDP) and prudent (PDP) dietary patterns were compared as a proxy to estimate ‘unhealthy’ (Rich in meat and processed foods) and ‘healthy’ diets (containing fruits or vegetables), respectively. Meta-analyses were carried out using random effects model to calculate overall risk estimates. Relative risks (RR) and 95% confidence intervals were estimated comparing the highest versus the lowest categories of dietary patterns for any of the forms of colon cancer studied.Results: 28 studies were meta-analysed. A WDP was associated with increased risk of CRC (RR 1.25; 95% CI 1.11, 1.40), and of CC (RR 1.30; 95% CI 1.11, 1.52). A PDP was negatively associated with CRC (RR 0.81; 95% CI 0.73, 0.91). Sensitivity analyses showed that individuals from North- and South- American countries had a significantly higher risk of CRC than those from other continents. Conclusion: A PDP might reduce the risk of CRC. Conversely, a WDP is associated with a higher risk of disease.
AU - Garcia,Larsen V
AU - Morton,V
AU - Norat,T
AU - Moreira,A
AU - Potts,J
AU - Bakolis,I
DO - 10.1038/s41430-018-0234-7
EP - 386
PY - 2018///
SN - 1476-5640
SP - 366
TI - Dietary patterns derived from Principal Component Analysis (PCA) and the risk of colorectal cancer: a systematic review and meta-analysis
T2 - European Journal of Clinical Nutrition
UR -
UR -
VL - 73
ER -