Imperial College London
Alternate

DrIainDunlop

Faculty of Engineering, Department of Materials

Reader in Biomaterials and Cell Engineering
 
 
 
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Contact

 

+44 (0)20 7594 6731i.dunlop

 
 
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Location

 

1.02Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gonzalez-Carter:2019:10.1016/j.nano.2018.08.011,
author = {Gonzalez-Carter, DA and Ong, ZY and McGilvery, CM and Dunlop, IE and Dexter, DT and Porter, AE},
doi = {10.1016/j.nano.2018.08.011},
journal = {Nanomedicine: Nanotechnology, Biology and Medicine},
pages = {1--11},
title = {L-DOPA functionalized, multi-branched gold nanoparticles as brain-targeted nano-vehicles},
url = {http://dx.doi.org/10.1016/j.nano.2018.08.011},
volume = {15},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The blood-brain barrier (BBB) is a protective endothelial barrier lining the brain microvasculature which prevents brain delivery of therapies against brain diseases. Hence, there is an urgent need to develop vehicles which efficiently penetrate the BBB to deliver therapies into the brain. The drug L-DOPA efficiently and specifically crosses the BBB via the large neutral amino acid transporter (LAT)-1 protein to enter the brain. Thus, we synthesized L-DOPA-functionalized multi-branched nanoflower-like gold nanoparticles (L-DOPA-AuNFs) using a seed-mediated method involving catechols as a direct reducing-cum-capping agent, and examined their ability to cross the BBB to act as brain-penetrating nanovehicles. We show that L-DOPA-AuNFs efficiently penetrate the BBB compared to similarly sized and shaped AuNFs functionalized with a non-targeting ligand. Furthermore, we show that L-DOPA-AuNFs are efficiently internalized by brain macrophages without inducing inflammation. These results demonstrate the application of L-DOPA-AuNFs as a non-inflammatory BBB-penetrating nanovehicle to efficiently deliver therapies into the brain.
AU  - Gonzalez-Carter,DA
AU  - Ong,ZY
AU  - McGilvery,CM
AU  - Dunlop,IE
AU  - Dexter,DT
AU  - Porter,AE
DO  - 10.1016/j.nano.2018.08.011
EP  - 11
PY  - 2019///
SN  - 1549-9634
SP  - 1
TI  - L-DOPA functionalized, multi-branched gold nanoparticles as brain-targeted nano-vehicles
T2  - Nanomedicine: Nanotechnology, Biology and Medicine
UR  - http://dx.doi.org/10.1016/j.nano.2018.08.011
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30189294
UR  - http://hdl.handle.net/10044/1/63483
VL  - 15
ER  -
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