Imperial College London
Alternate

DrIainDunlop

Faculty of Engineering, Department of Materials

Reader in Biomaterials and Cell Engineering
 
 
 
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Contact

 

+44 (0)20 7594 6731i.dunlop

 
 
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Location

 

1.02Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Delcassian:2013:10.1021/nl403252x,
author = {Delcassian, D and Depoil, D and Rudnicka, D and LIu, M and Davis, DM and Dustin, ML and Dunlop, IE},
doi = {10.1021/nl403252x},
journal = {Nano Letters},
title = {Nanoscale ligand spacing influences receptor triggering in T cells and NK cells},
url = {http://dx.doi.org/10.1021/nl403252x},
year = {2013}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Bioactive nanoscale arrays were constructed to ligate activating cell surface receptors on T cells (the CD3 component of the TCR complex) and NK cells (CD16). These arrays are formed from biofunctionalized gold nanospheres with controlled interparticle spacing in the range 25 – 104 nm. Responses to these nanoarrays were assessed using the extent of membrane-localized phosphotyrosine in T cells stimulated with CD3-binding nanoarrays, and the size of cell contact area for NK cells stimulated with CD16-binding nanoarrays. In both cases, the strength of response decreased with increasing spacing, falling to background levels by 69 nm in the T cell/anti-CD3 system and 104 nm for the NK cell/anti-CD16 system. These results demonstrate that immune receptor triggering can be influenced by the nanoscale spatial organization of receptor/ligand interactions.
AU  - Delcassian,D
AU  - Depoil,D
AU  - Rudnicka,D
AU  - LIu,M
AU  - Davis,DM
AU  - Dustin,ML
AU  - Dunlop,IE
DO  - 10.1021/nl403252x
PY  - 2013///
TI  - Nanoscale ligand spacing influences receptor triggering in T cells and NK cells
T2  - Nano Letters
UR  - http://dx.doi.org/10.1021/nl403252x
ER  -
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