Imperial College London
Alternate

DrIainDunlop

Faculty of Engineering, Department of Materials

Reader in Biomaterials and Cell Engineering
 
 
 
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Contact

 

+44 (0)20 7594 6731i.dunlop

 
 
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Location

 

1.02Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Harrison:2015:10.1002/adfm.201501277,
author = {Harrison, RH and Steele, JAM and Chapman, R and Gormley, A and Chow, L and Mahat, M and Podhorska, L and Palgrave, R and Payne, D and Hettiaratchy, S and Dunlop, IE and Stevens, M},
doi = {10.1002/adfm.201501277},
journal = {Advanced Functional Materials},
pages = {5748--5757},
title = {Modular and versatile spatial functionalization of tissue engineering scaffolds through fiber-initiated controlled radical polymerization},
url = {http://dx.doi.org/10.1002/adfm.201501277},
volume = {25},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Native tissues are typically heterogeneous and hierarchically organized, and generating scaffolds that can mimic these properties is critical for tissue engineering applications. By uniquely combining controlled radical polymerization (CRP), endfunctionalization of polymers, and advanced electrospinning techniques, a modular and versatile approach is introduced to generate scaffolds with spatially organized functionality. Polyεcaprolactone is end functionalized with either a polymerizationinitiating group or a cellbinding peptide motif cyclic ArgGlyAspSer (cRGDS), and are each sequentially electrospun to produce zonally discrete bilayers within a continuous fiber scaffold. The polymerizationinitiating group is then used to graft an antifouling polymer bottlebrush based on poly(ethylene glycol) from the fiber surface using CRP exclusively within one bilayer of the scaffold. The ability to include additional multifunctionality during CRP is showcased by integrating a biotinylated monomer unit into the polymerization step allowing postmodification of the scaffold with streptavidincoupled moieties. These combined processing techniques result in an effective bilayered and dualfunctionality scaffold with a celladhesive surface and an opposing antifouling noncelladhesive surface in zonally specific regions across the thickness of the scaffold, demonstrated through fluorescent labelling and cell adhesion studies. This modular and versatile approach combines strategies to produce scaffolds with tailorable properties for many applications in tissue engineering and regenerative medicine.
AU  - Harrison,RH
AU  - Steele,JAM
AU  - Chapman,R
AU  - Gormley,A
AU  - Chow,L
AU  - Mahat,M
AU  - Podhorska,L
AU  - Palgrave,R
AU  - Payne,D
AU  - Hettiaratchy,S
AU  - Dunlop,IE
AU  - Stevens,M
DO  - 10.1002/adfm.201501277
EP  - 5757
PY  - 2015///
SN  - 1616-301X
SP  - 5748
TI  - Modular and versatile spatial functionalization of tissue engineering scaffolds through fiber-initiated controlled radical polymerization
T2  - Advanced Functional Materials
UR  - http://dx.doi.org/10.1002/adfm.201501277
UR  - https://onlinelibrary.wiley.com/doi/10.1002/adfm.201501277
UR  - http://hdl.handle.net/10044/1/26390
VL  - 25
ER  -
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